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Clopidogrel carboxylic acid is metabolized mainly by UGT2B7 and UGT2B4 in the liver and by UGT2B17 in the small intestinal wall.
UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.
These data indicate that knocking down PAPSS increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 activity
Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo
The UGT1A8 and UGT2B4 genotypes associated with decreased predicted enzyme activities, were significantly associated with an increased risk of esophageal squamous cell carcinoma.
The variation pattern upstream UGT2B4 is highly unusual and may be the result of balancing selection.
Extensive splicing of transcripts of the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation.
Farnesoid X receptor (FXR) induces the UGT2B4 enzyme in hepatocytes; this study identifies UGT2B4 as a novel FXR target gene.
UGT2B4 expression is regulated by PPARalpha
P.1053: "...UGT2B4...is...fairly common in Caucasians...and Africans..."but...still rare in ...Japanese..." P.1054: "...genotyping UGT2B4...in Japanese...would be useful for studies on... association between haplotypes and pharmacokinetic...parameters."
Results strongly indicated that the presence of an aromatic residue at position 33 is important for the activity and specificity of UGTB4.
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
UDP glucuronosyltransferase 2B4
, UDP-glucuronosyltransferase 2B4
, UDP-glucuronyltransferase, family 2, beta-4
, UDPGT 2B4
, hyodeoxycholic acid
, hyodeoxycholic acid-specific UDPGT
, UDP glucuronosyltransferase 2 family, polypeptide B17
, UDP glycosyltransferase 2 family, polypeptide B28
, UDP glucuronosyltransferase 2 family, polypeptide B4