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Human Polyclonal DNAJA3 Primary Antibody for IF, WB - ABIN522528
Carnini, Scott, Ahrendt, Proft, Winkfein, Kim, Colicos, Braun: Cell line specific modulation of extracellular a?42 by Hsp40. in PLoS ONE 2012
Tid1 deficiency reduces ATP production.
Dnaja3 is crucial for mitochondrial biogenesis through its chaperone activity on Polga and has a role in preventing dilated cardiomyopathy
Tid-1S in Th2 cells following activation has a role in induction of apoptosis resistance during the activation of Th2 cells
Tid1 is critical for early mammalian development, most likely for its function in sustaining embryonic-cell survival, which requires its association with Hsp70.
It is proposed that Tid1 contributes to cell aging by acting as a repressor of NF-kappa B signaling.
Overexpression of the N-terminal half of Tid1 induced agrin- and MuSK-independent phosphorylation and clustering of AChRs. These results demonstrate that Tid1 is an essential component of the agrin signaling pathway, crucial for synaptic development.
Impaired stoichiometry between mtHsp40 and mtHsp70 promotes Opa1L cleavage, leading to cristae opening, decreased OXPHOS, and triggering of mitochondrial fragmentation after reduction in their chaperone function.
The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-kappaB Signaling.
Tid1 increases autophagic flux by interacting with the Beclin 1-containing autophagy protein complex.
TID1 prevents complex I aggregation and support the existence of a TID1-mediated stress response to ATP synthase inhibition
Tid1 acts as a tumor suppressor by inhibiting EGFR signaling through interaction with EGFR/HSP70/HSP90 and enhancing EGFR ubiquitinylation and degradation.
Data show that elevated DnaJA3 induces dynamin-related protein 1 (Drp1)-depedendent mitochondrial fragmentation and decreased cell viability.
loss of hTid-1(S) expression in the basal layer of skin epidermis correlates with the enhanced HSP27 phosphorylation, keratinocyte hyperproliferation, and excess actin cytoskeleton organization in lesional psoriatic skin
Tid1 and CHIP play pivotal roles in affecting the levels of ErbB2 protein, and that both are significant prognostic indicators of breast cancer patient survival.
findings denote hTid-1(S) as an essential regulatory component of MetR signaling
hTid1 negatively regulates the expression and transcriptional activity of STAT5b and suppresses the growth of hematopoietic cells transformed by an oncogenic form of STAT5b.
htid is a tissue independent and evolutionarily conserved suppressor of ErbB-2.
amino-terminal segment of APC promotes cell sensitivity to apoptosis modulated through its binding to 40- and 43-kilodalton hTID-1 isoforms.
role as a repressor of Ikappa B kinase beta subunit
an important cell death regulator and could exert tumor suppressor activity
findings suggest that the status of hTid-1 in gliomas may contribute to their susceptibility to cell death triggers
hTid-1 represses the activity of NF-kappaB through physical and functional interactions with the IKK complex and IkappaB
the carboxyl-terminal end of TID1 (residues 224-429) bound to Trk at the activation loop (Tyr(P)(683)-Tyr(684)(P)(684)
Tid-1(L) may play a critical role in pVHL-mediated tumor suppression by modulating the pVHL-dependent HIF-1alpha stability.
Tid1 is critical for the transition of double-negative to double-positive cells in early T cell development through modulation of antiapoptotic bcl-2 expression.
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
dnaJ homolog subfamily A member 3, mitochondrial
, DnaJ (Hsp40) homolog, subfamily A, member 3
, dnaJ protein Tid-1
, tumorous imaginal discs protein Tid56 homolog
, hepatocellular carcinoma-associated antigen 57