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Human Glutamate Dehydrogenase 2 (GLUD2) interaction partners

1. hGDH2 evolution bestowed large human neurons with enhanced glutamate (show GRIN1 Antibodies) metabolizing capacity, thus strengthening cortical excitatory transmission.

2. This study demonstrated that hGDH2 expression increases capacity for uptake and oxidative metabolism of glutamate (show GRIN1 Antibodies), particularly during increased workload and hypoglycemia.

3. This proliferation requires glutamate dehydrogenase 2, which synthesizes glutamate (show GRIN1 Antibodies) from ammonia and alpha-ketoglutarate and is expressed in MCF7 and T47D cells. Our findings provide insight into how cancer cells survive under glutamine (show GFPT1 Antibodies) deprivation conditions and thus contribute to elucidating the mechanisms of tumor growth.

4. The expression of GLUD2 was identified in the cellular and subcellular compartments of numerous tissues.

5. Notably, the introduction of GLUD2 did not affect glutamate (show GRIN1 Antibodies) levels in mice, consistent with observations in the primates. Instead, the metabolic effects of GLUD2 center on the tricarboxylic acid cycle, suggesting that GLUD2 affects carbon flux during early brain development, possibly supporting lipid biosynthesis.

6. Study of the expression of the GDH1 (show GLUD1 Antibodies)/2 in human steroidogenic organs revealed that, while GDH2 was expressed specifically in steroid-synthesizing cells, GDH1 (show GLUD1 Antibodies) was expressed both in the cells that produce steroids and in those that lack endocrine function.

7. IDH1 (show IDH1 Antibodies)(R132H) exhibits a growth-inhibitory effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific enzyme purportedly optimized to facilitate glutamate (show GRIN1 Antibodies) turnover in human forebrain.

8. hGDH2 can operate efficiently in the relatively acidic environment that prevails in astrocytes following glutamate (show GRIN1 Antibodies) uptake [review]

9. [review] Whereas GDH2 in most mammals is encoded by a single functional GLUD1 (show GLUD1 Antibodies) gene expressed widely, humans have acquired through retroposition an X-linked GLUD2 gene that encodes a highly homologous isoenzyme GDH2 expressed in testis (show XKR3 Antibodies) and brain.

10. Human GDH1 (show GLUD1 Antibodies) appears to act like bovine GDH1 (show GLUD1 Antibodies), but human GDH2 does not show the same enhancement of branched chain alpha-keto acid dehydrogenase complex enzyme activities.

Arabidopsis thaliana Glutamate Dehydrogenase 2 (GLUD2) interaction partners

1. these data illustrate the essential role of EIN3-regulated GDH (show UGDH Antibodies) activity in metabolic adjustment during anoxia-reoxygenation.

2. In leaves and stems of arabidopsis and tobacco, both the alpha- and beta-subunits of Glutamate (show GRIN2A Antibodies) dehydrogenase are targeted to the mitochondria of the companion cells.

3. Protein phosphorylation by serine/threonine protein kinases is the essential step required for signal transduction into nucleus resulting in the induction of glutamate dehydrogenase 2 expression.