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Genetic interaction experiments demonstrate Syx4 (show STX4 Proteins), Syt4, and Nlg1 regulate synaptic growth and plasticity through both shared and parallel signaling pathways.
A retrograde signal mediated by Synaptotagmin 4 is transmitted to the postsynaptic cell through anterograde delivery of Synaptotagmin 4 via exosomes.
Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE (show NAPA Proteins)-catalyzed membrane fusion.
Synaptotagmins I and IV promote transmitter release independently of Ca(2 (show CA2 Proteins)+) binding in the C(2)A domain
results demonstrate that acute plasticity and synapse-specific growth require Syt 4-dependent retrograde signaling at Drosophila neuromuscular junctions
Syt 4 regulates activity-dependent release of postsynaptic retrograde signals that promote synaptic plasticity, similar to the role of Syt 1 (show SYT1 Proteins) as a Ca(2 (show CA2 Proteins)+) sensor for presynaptic vesicle fusion.
Syt4 Overexpression Represses Basal Insulin (show INS Proteins) Secretion and Impairs Islet Morphogenesis.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3 (show BAG3 Proteins), APOA1 (show APOA1 Proteins), and VAV3 (show VAV3 Proteins), except for VGF (show VGF Proteins) protein, there was a trend between the expression of these four genes and their protein levels.
Synaptotagmin 4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased synaptotagmin 4 binding to vesicles.
BDNF (show BDNF Proteins) secretion mediated by syt (show SS18 Proteins)-IV is subject to extensive temporal and spatial control to modulate the spatial pattern of synaptic efficacy in networks of neurons
Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels.
these data suggest that syt (show SS18 Proteins) IV plays a role both in the Golgi and in the maintenance of normal numbers of synaptic vesicles in presynaptic terminals
propose that Syt (show SS18 Proteins) IV is essential for the regulated release of glutamate (show GRIN1 Proteins) from astrocytes and is a candidate Ca2 (show CA2 Proteins)+ sensor for gliotransmission by these nonneuronal cells
Syt (show SS18 Proteins) IV plays a role in rodent mood-related behavior by regulating synaptic function in the neuronal networks that modulate these behaviors.
Syt (show SS18 Proteins) IV is a presynaptic negative regulator of short-term plasticity in area CA1 (show CA1 Proteins) of the hippocampus and is required for some, but not all, forms of hippocampus-dependent memory.
Given the neuroendocrine functions of the posterior pituitary, changes in Syt (show SS18 Proteins) IV levels could be involved in endocrine transitions involving alterations in the release of the neuropeptides oxytocin and vasopressin (show AVP Proteins)
Thus, regulation of BDNF (show BDNF Proteins) secretion by syt (show SS18 Proteins)-IV emerges as a mechanism for maintaining synaptic strength in a useful range during LTP (show SCP2 Proteins).
From the results of this study the author proposed that the differential expression of synaptotagmins determines the characteristic Ca2 (show CA2 Proteins)+ sensitivity of vesicle fusion at hair cell synapses.
The protein encoded by this gene belongs to the synaptotagmin family. Members of this family are multi-domained, integral membrane proteins of synaptic vesicles, and are thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. This gene is primarily expressed in the nervous tissues.
, synaptotagmin 4
, synaptotagmin IV