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Human Polyclonal STX4 Primary Antibody for ICC, IP - ABIN1742221
Arasaki, Roy: Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b. in Traffic (Copenhagen, Denmark) 2010
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Human Polyclonal STX4 Primary Antibody for ICC, IP - ABIN1742222
Baron, Ozgen, Klunder, de Jonge, Nomden, Plat, Trifilieff, de Vries, Hoekstra: The major myelin-resident protein PLP is transported to myelin membranes via a transcytotic mechanism: involvement of sulfatide. in Molecular and cellular biology 2014
Show all 4 Pubmed References
Human Polyclonal STX4 Primary Antibody for ICC, IF - ABIN4357295
Rivero, Garin, Ormazabal, Silva, Carvajal, Gabler, Romero, Vega: Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS). in Reproductive biology and endocrinology : RB&E 2012
Show all 3 Pubmed References
Bat Polyclonal STX4 Primary Antibody for WB - ABIN611193
Hauser, Bardroff, Pyrowolakis, Jentsch: A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. in The Journal of cell biology 1998
Rat (Rattus) Monoclonal STX4 Primary Antibody for ICC, IP - ABIN1742220
Milovanovic, Honigmann, Koike, Göttfert, Pähler, Junius, Müllar, Diederichsen, Janshoff, Grubmüller, Risselada, Eggeling, Hell, van den Bogaart, Jahn: Hydrophobic mismatch sorts SNARE proteins into distinct membrane domains. in Nature communications 2015
Genetic interaction experiments demonstrate Syx4, Syt4 (show SYT4 Antibodies), and Nlg1 regulate synaptic growth and plasticity through both shared and parallel signaling pathways.
Confocal immunofluorescence microscopy revealed a colocalization of syntaxin 4 with a MVB-specific marker, exosomes and hepatitis C virus (HCV) core, which suggests a fraction of syntaxin 4 is associated with exosomes loaded with HCV. Altogether, it is assumed that syntaxin 4 is a novel essential cellular factor for the release of HCV.
The authors found that activation of dendritic cells by bacterial lipopolysaccharide leads to increased Forster resonance energy transfer-fluorescence of fluorescently labeled syntaxin 4 with VAMP3 (show VAMP3 Antibodies) specifically at the plasma membrane, indicating increased SNARE (show NAPA Antibodies) complex formation, whereas FRET with other tested SNAREs was unaltered.
Data suggest MUNC18C is required for STX4-mediated invadopodium formation and tumor invasion of extracellular matrix; N-terminal STX4 fragment binds to MUNC18C and inhibits interactions of STX4 with synaptosome-associated protein 23 (SNAP23 (show SNAP23 Antibodies)) and vesicle-associated membrane protein 2 (VAMP2 (show VAMP2 Antibodies)). Fibrosarcoma/adenocarcinoma cell lines were used in these studies. (MUNC18C = syntaxin binding protein MUNC18C; STX4 = syntaxin 4)
The analysis revealed three candidate genes GSK3B, PTPN1 (show PTPN1 Antibodies), STX4 that are differentially expressed in study subjects. GSK3B was highly significant in Ps-T2D (P=0.00018, FR=-26.6), followed by Ps (P=0.0028, FR=-14.5) and T2D groups (P=0.032, FR=-5.9). PTPN1 (show PTPN1 Antibodies) showed significant association only with PS-T2D (P=0.00027, FR=-8.5). STX4 showed significant association with both Ps (P=0.0002, FR=-20) and Ps-T2D (P=0.0016, FR=-11.2).
When the expression of STX4 mRNA was inhibited with short or small interfering, or silencing, RNA in macrophages, the survival of Brucella melitensis was significantly reduced.
Syntaxin-4 has a role in mediating exocytosis of pre-docked and newcomer insulin (show INS Antibodies) granules underlying biphasic glucose-stimulated insulin (show INS Antibodies) secretion in human pancreatic beta cells
Increased level of SNAP23 (show SNAP23 Antibodies)-Syntaxin4-VAMP7 (show VAMP7 Antibodies) interaction correlates with decreased Syntaxin4 phosphorylation and trafficking of MT1-MMP (show MMP14 Antibodies) to invadopodia during cellular invasion.
upregulation of Syntaxin 4 is sufficient to significantly improve insulin (show INS Antibodies) secretory function to human type 2 diabetes islets retaining low levels of residual function
STX4 is implicated in the antibody secretion.
Syntaxin-4 plays a vital role in exocytosis of IgE from plasma cells. Knock-down of syntaxin-4, but not VAMP3 dramatically reduced IgE secretion from U266 plasma cells causing it to accumulate in the cell.
Stx4a plays a critical role in bone matrix production by osteoblasts.
Syntaxin-4 not only bound to laminin but also latched onto the glycosaminoglycan side chains of syndecan-1 (show SDC1 Antibodies), a laminin receptor that mediates epithelial morphogenesis. Thus, temporal extracellular extrusion of syntaxin-4 emerged as a novel regulatory element for laminin-induced mammary epithelial cell behaviors.
Syn4 transgenic mice with high level expression of Syn4 had a significant extension of lifespan (33% increase in median) and showed increased peripheral insulin (show INS Antibodies) sensitivity, even at ages where controls exhibited age-related insulin (show INS Antibodies) resistance.
Non-directional stimulation with extracellular syntaxin-4 induces a dramatic morphological change in teratocarcinoma F9 cells and in several endodermal markers, both of which effects are reminiscent of the cells treated with all-trans retinoic acid.
Delivery of GLUT4 (show SLC2A4 Antibodies) to the plasma membrane is mediated by formation of functional SNARE (show VTI1B Antibodies) complexes containing syntaxin4, SNAP23 (show SNAP23 Antibodies), and VAMP2 (show VAMP2 Antibodies).
data support a mechanistic model for gelsolin's role in insulin (show INS Antibodies) exocytosis: gelsolin (show GSN Antibodies) clamps unsolicited soluble N-ethylmaleimide-sensitive factor (show NSF Antibodies) attachment receptor-regulated exocytosis through association with Syn4 which is relieved upon stimulus-induced calcium influx to activate gelsolin (show GSN Antibodies) to facilitate insulin (show INS Antibodies) exocytosis
Syntaxin 4 activation and insulin (show INS Antibodies) release in the absence of the glucose stimulus, consistent with nitrosative stress and dysfunctional exocytosis
functions as the necessary t-SNARE (show VTI1B Antibodies) protein responsible for correct fusion of the GLUT8 (show SLC2A8 Antibodies)-containing vesicle with the plasma membrane in the mouse blastocyst
Interacts with tomosyn (show STXBP5 Antibodies) and plays a role in insulin (show INS Antibodies)-stimulated GLUT4 (show SLC2A4 Antibodies) translocation.
female Syn4 transgenic mice exhibited an increased rate of glucose clearance during glucose tolerance tests that was repressible by the administration of tetracycline
Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity).
, syntaxin 4
, renal carcinoma antigen NY-REN-31
, syntaxin 4A (placental)