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the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (show CA2 Proteins)+)-regulated tethers to the Pplasma membrane.
the combined inactivation of all 3 E-Syt (show SS18 Proteins) genes has no effect on mouse viability or fertility.
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity).
, synaptotagmin 3