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Human CD4 Protein expressed in Human Cells - ABIN2002783
Ryu, Truneh, Sweet, Hendrickson: Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices. in Structure (London, England : 1993) 1994
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Mouse (Murine) CD4 Protein expressed in Human Cells - ABIN2007381
Baldzizhar, Fedorchuk, Jha, Rathinam, Henegariu, Czyzyk: Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. in The Journal of biological chemistry 2013
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data showed the critical role of the first extracellular domain of CD4, by obtaining mice with a loss of function mutation from Ile to Asn at the position 99 of CD4 (I99N).
results suggest that CD4 CD8 (show CD8A Proteins) double knockout (DN)T cells can develop efficiently in vivo and chronic exposure to bacterial superantigens may precipitate a lupus-like autoimmune disease through activation of DNT (show NT5C Proteins) cells
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
High-fat diet - induced type 2 diabetes decreases the number of ileum IL17 (show IL17A Proteins)/RORgammaT CD4 T cells.
Results indicate that hypomethylation of Cd4 antigen correlates with stable CD4 expression.
CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase (show YES1 Proteins) p56lck (show LCK Proteins)
This study establishes an important role of IgE in abdominal aortic aneurysms pathogenesis by activating CD4+ T cells, mast cells, and macrophages.
5-kb cis (show CISH Proteins)-element is required in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance of CD4 expression, and suggest that inactivation of the cis (show CISH Proteins)-element by DNA methylation (show HELLS Proteins)
Both type I CD8 (show CD8A Proteins)+ cytotoxic (Tc1 (show C8orf4 Proteins)) cells and interleukin (IL)-17 (show IL17A Proteins)-producing CD8 (show CD8A Proteins)+ (Tc17) cells mediate effective antitumor immunity through distinct effector mechanisms, but Tc1 (show C8orf4 Proteins) cells are superior to Tc17 cells in mediating tumor regression.
Accumulation of CD4 positive effector T cells is a critical step in the progression from mild glomerulonephritis to severe crescentic glomerulonephritis accompanied by tubulointerstitial inflammation and loss of kidney function.
Our results indicate that CD4 expression and older age are adverse prognostic factors in wild-type NPM1 (show NPM1 Proteins), FLT3 (show FLT3 Proteins)-ITD-negative CN-AML (show RUNX1 Proteins).
We investigated the prevalence, magnitude and phenotype of CTAg (show CTAG1B Proteins)-specific T cells in the blood of patients with testicular germ cell tumors (TGCTs). CD8 (show CD8A Proteins)(+) and CD4(+) T-cell responses against MAGE (show MAGEB10 Proteins)-A family antigens were present in 44% (20/45) of patients' samples assayed by ex vivo IFN-gamma (show IFNG Proteins) ELISPOT. Spontaneous T-cell immunity against CTAg (show CTAG1B Proteins) proteins therefore develops in many patients with testicular cancer.
Depletion of the gamma2 or mu1A (AP1M1 (show AP1M1 Proteins)) subunits of AP-1 (show FOSB Proteins), but not of gamma1 (AP1G1 (show AP1G1 Proteins)), precludes Nef-mediated lysosomal degradation of CD4.
findings provide a mechanistic explanation for previous observations that dimerization-defective Nef mutants fail to down-regulate CD4 and validate the Nef dimerization interface as a target site for antiretroviral drug development
Mouse leukemia cell lines that could express hCD4 and CCR5 were thus established to facilitate normal entry of HIV-1 so that a human CD4/CCR5 transgenic mice cell model can be used to investigate the transmission and pathogenesis of HIV/AIDS and potential antiviral drugs against this disease.
The percentage of lamina propia CD4+LAP+ cells is increased in active ulcerative colitis, showing reduced suppressor activity due to their increased proportion of intracellular IL-17 (show IL17A Proteins) expression.
The study gives insights into the role of CD4 on cell membrane mechanical characteristics.
A decrease of CD4(+) CD25 (show IL2RA Proteins)(+) CD127 (show IL7R Proteins)(low) FoxP3 (show FOXP3 Proteins)(+) regulatory T cells with impaired suppressive function had been found in untreated ulcerative colitis patients.
Redox shuffling of the allosteric disulfide results in previously undescribed conformational changes in CD4 that are likely important for its interaction with its protein partners.
Increased levels of activated and highly susceptible HIV-1 target cells, reduced CD4 and enhanced CXCR4 (show CXCR4 Proteins) cell surface expression, together with the high susceptibility to FAS (show FAS Proteins)-induced programmed cell death may contribute to the rapid CD4+ T cell depletion.
The frequency and expression of a CD4 variant in microminipigs are described.
These data help clarify the regulatory mechanism of DNA methylation (show HELLS Proteins) of the CD4 gene in non-immune cell response to virus replication.
These results suggest that CD4 plays a role in production traits as well as in immune function. The identified SNPs could be used as genetic markers for selection of dairy cows with improved fat percentage. We propose further studies of these SNPs in a larger population as well as further investigations of the function of this gene.
These results suggested that the SNPs in CD4 and STAT5b (show STAT5B Proteins) may be potential genetic markers for SCS (show TWIST1 Proteins) and milk/protein (show CSN2 Proteins) yields selecting and warrant further functional research.
The DNA methylation (show HELLS Proteins) level of the CD4 gene was strongly influenced by mastitis in Chinese Holstein cattle.
These findings revealed that despite the existence of a distinct bovine CD4(+)CD25 (show IL2RA Proteins)(high) T cell population, which showed Foxp3 (show FOXP3 Proteins) transcription/expression, natural regulatory activity did not reside in this cell population
The absence of CD4 T cells results in failure to produce antibodies that neutralize CD4-independent SIV Envs and CD4-pretriggered control SIV Envs.
study found noticeable variation in the first variable region V1 of CD4 and in intron six among the subspecies of chimpanzees.
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
, T-cell surface glycoprotein CD4
, T-cell differentiation antigen L3T4
, T-cell surface antigen T4/Leu-3
, T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)
, CD4 antigen (p55)
, CD4 receptor
, W3/25 antigen
, lymphocyte antigen CD4
, cell surface glycoprotein CD4