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regulatory effect of the mannose receptor (MR) was mediated by a direct interaction with CD45 on the T cell, inhibiting its phosphatase activity, which resulted in up-regulation of CTLA-4 (show CTLA4 Proteins) and the induction of T-cell tolerance. Inhibition of CD45 prevented expression of B-cell lymphoma 6 (Bcl-6 (show BCL6 Proteins)), a transcriptional inhibitor that directly bound the CTLA-4 (show CTLA4 Proteins) promoter and regulated its activity
pUL11 induces IL-10 (show IL10 Proteins) producing T cells as a result of pUL11 binding to the CD45 phosphatase on T cells.
Expression of IL10R (show IL10RA Proteins) subunits within the leukocyte population (CD45(+) cells) was significantly higher in primary brain tumors than in metastases.
As CD45 expression vs. SSc (show CYP11A1 Proteins) is routinely measured in the diagnostics of acute leukemias.
A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity.
Our findings suggest that CD45 is a key regulator of BCR (show BCR Proteins)-signaling thresholds mediated by T-cell help
we demonstrate for the first time the physiological existence of ct-CD45 in human plasma and show that it may be an extrinsic factor contributing to the maintenance of human T-cell quiescence.
Our findings suggest that if w/h ratio on SSC (show CYP11A1 Proteins) versus CD45 plot is less than 1.6, AML (show RUNX1 Proteins) may be considered, and if it is more than 1.6, ALL may be diagnosed. Using morphometric analysis of the blast cluster on SSC (show CYP11A1 Proteins) versus CD45, it was possible to distinguish between ALL and AML (show RUNX1 Proteins), and their subtypes.
Use of the common leukocyte marker CD45 increases the sensitivity of the diagnosis of lymphocytic myocarditis.
Review/Meta-analysis: Rheumatoid arthritis patients with PTPRC rs10919563 A allele show a poor response to anti-TNF (show TNF Proteins) therapy.
Data show that CD45(+) uncultured adipose tissue derived stromal cells (u-ADSCs) acting phenotypically and functionally like M2-type macrophages (MPhis), contributed to the repair of liver tissue undergoing inflammation.
We identify differing roles for the phosphatase CD45 in innate and adaptive immune cells in intestinal inflammation. CD45 is required for optimal GM-CSF (show CSF2 Proteins) and RA production in innate immune cells that affects alpha4beta7 expression and the homing of effector T cells to the intestine. Conversely, the absence of CD45 on adaptive immune cells leads to enhanced alpha4beta7 expression on T cells and homing to the intestine.
T cell receptor / TLR2 co-stimulation expands CD25 (show IL2RA Proteins)+CD45Rbhi T cells.
Both the number of lung CD31 (show PECAM1 Proteins)-CD45-Sca-1+ cells and the expression levels of the Shh (show SHH Proteins) signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh (show SHH Proteins) signaling pathway are reactivated during acute adenovirus infection.
the transient upregulation of IL-1beta (show IL1B Proteins) and PTPRC/CD45 during the early phase as well as the increased expression of collagen type I at later stages of repair and validate the differential expression of miR (show MLXIP Proteins)-204, miR (show MLXIP Proteins)-205, and miR (show MLXIP Proteins)-31 in skin wounds.
Increased numbers of CD4 (show CD4 Proteins)(+)CD45RA(-)FoxP3 (show FOXP3 Proteins)(low) cells may cause an imbalance between Treg and Th17 cells that is mainly localized to the colon.
Aging induces loss of stemness with concomitant gain of myogenic properties of a pure population of CD34 (show CD34 Proteins)+/CD45- muscle derived stem cells.
deletion of Pten in CD45-expressing cells induces development of T-cell acute lymphoblastic leukemia and lymphoma, but not other hematologic malignancies
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
receptor-type tyrosine-protein phosphatase C
, leukocyte common antigen, CD45
, protein tyrosine phosphatase, receptor type, C
, CD45 antigen
, leukocyte common antigen
, receptor-type tyrosine-protein phosphatase C-like
, T200 glycoprotein
, T200 leukocyte common antigen
, protein tyrosine phosphatase, receptor type, c polypeptide
, lymphocyte antigen 5
, lymphocyte common antigen
, Protein tyrosine phosphatase, receptor-type, c polypeptide
, leucocyte common antigen
, leukocyte common antigen A
, leukocyte common antigen B
, membrane tyrosine phosphatase