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anti-Human GAB2 Antibodies:
anti-Rat (Rattus) GAB2 Antibodies:
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Human Polyclonal GAB2 Primary Antibody for FACS, WB - ABIN1881358
Yamasaki, Nishida, Hibi, Sakuma, Shiina, Takeuchi, Ohnishi, Hirano, Saito: Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. in The Journal of biological chemistry 2001
Show all 2 Pubmed References
Human Polyclonal GAB2 Primary Antibody for IHC, IHC (p) - ABIN4313051
Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. in Molecular & cellular proteomics : MCP 2006
Human Polyclonal GAB2 Primary Antibody for ELISA, WB - ABIN253292
Bentires-Alj, Gil, Chan, Wang, Wang, Imanaka, Harris, Richardson, Neel, Gu: A role for the scaffolding adapter GAB2 in breast cancer. in Nature medicine 2006
Human Polyclonal GAB2 Primary Antibody for IF (p), IHC (p) - ABIN681178
Zhan, Xu, Chen, Wang, Yanfeng, Dan, Zhan, Shi: Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model. in Synapse (New York, N.Y.) 2014
The proto-oncogene (show RAB1A Antibodies) GAB2 (11q14.1) was significantly amplified in non-smokers patients and GAB2 protein was relatively up-regulated in non-smoker than smoker tissues. GAB2 may represent a potential biomarker for lung SCC (show CYP11A1 Antibodies) in non-smokers
There was no significant association between single nucleotide polymorphisms (SNPS) of GAB2 rs2373115 (G > T) and PICALM (show PICALM Antibodies) rs541458 (C > T) and Alzheimer's disease (AD). The allele T of rs3851179 in PICALM (show PICALM Antibodies) was associated with a 13 % increase in the risk of AD. Seven SNPs on SORL1 (show SORL1 Antibodies) were significantly associated with AD.
Results show that up-regulation of Gab2 expression was found to be positively correlated with VEGF (show VEGFA Antibodies) in colorectal cancer (CRC (show CALR Antibodies)) tissues, and suggest that Gab2 promotes intestinal tumor growth and angiogenesis through upregulation of VEGF (show VEGFA Antibodies) expression mediated by the MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies)/c-Myc (show MYC Antibodies) pathway.
The model showed agreement at several key nodes, involving scaffolding proteins Gab1 (show GAB1 Antibodies), Gab2 and their complexes with Shp2 (show PTPN11 Antibodies). VEGFR2 (show KDR Antibodies) recruitment of Gab1 (show GAB1 Antibodies) is greater in magnitude, slower, and more sustained than that of Gab2. As Gab2 binds VEGFR2 (show KDR Antibodies) complexes more transiently than Gab1 (show GAB1 Antibodies), VEGFR2 (show KDR Antibodies) complexes can recycle and continue to participate in other signaling pathways.
The authors showed that GAB2 is cleaved at G238 during Coxsackievirus type B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676.
Studied BAK1 (show BAK1 Antibodies), SPRY4 (show SPRY4 Antibodies) and GAB2 SNPs in pediatric germ cell tumors(GCT (show QPCT Antibodies)); found a variant in SPRY4 (show SPRY4 Antibodies) was associated with reduced risk of GCT (show QPCT Antibodies); a variant in BAK1 (show BAK1 Antibodies) was positively associated with GCT (show QPCT Antibodies) with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT (show QPCT Antibodies).
overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating expression of CXCL1 (show CXCL1 Antibodies), CXCL2 (show CXCL2 Antibodies) and CXCL8 (show IL8 Antibodies) that is IKKbeta (show IKBKB Antibodies)-dependent.
GAB2 is a key intermediary between YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) and the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway.
The findings of this study suggested that GAB2 rs2373115 may contribute to Alzheimer's disease susceptibility only in European population but not in East Asian population.
ERK1 (show MAPK3 Antibodies) and ERK2 (show MAPK1 Antibodies) interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 (show MAPK1/3 Antibodies) activation.
we demonstrated for the first time that Gab2 deficiency has a profound effect on the course of disease in an in vivo chronic myeloid leukemia (show BCL11A Antibodies) model
High Gab2 expression is associated with myeloproliferative neoplasm.
Gab2 may be a disease-associated protein that is induced by pathogenic factors to amplify and coordinate multifactor-induced signals to govern disease development in the liver.
Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1 (show GAB1 Antibodies)/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1 (show GAB1 Antibodies)/Gab2 are recruited to Il4r (show IL4R Antibodies), synergistically enhancing downstream signal amplification. (Gab1 (show GAB1 Antibodies) = growth factor receptor bound protein 2-associated protein 1 (show GAB1 Antibodies); Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r (show IL4R Antibodies) = interleukin-4 receptor (show IL4R Antibodies))
Given that GAB2 is dispensable for normal hematopoiesis, GAB2 and its effectors PI3K and SHP2 represent promising targets for therapy in Ph(+)hematologic neoplasms
Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
These results define a novel role for Gab2 in mediating mucin (show SLC13A2 Antibodies) gene expression and GCH (show GCH1 Antibodies); these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases.
Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion
Data indicate that fetal liver cells isolated from homozygous STAT5 (show STAT5A Antibodies) mutant mice lacking Gab2 showed significant reduction in HSC (show FUT1 Antibodies) number and survival.
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
GRB2-associated binding protein 2
, GRB2-associated-binding protein 2
, Grb2-associated binder 2
, growth factor receptor bound protein 2-associated protein 2
, GRB2-associated binder 2
, Grb2 associated binder 2
, PH domain-containing adaptor molecule p97