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Human Polyclonal GAB2 Primary Antibody for FACS, WB - ABIN1881358
Yamasaki, Nishida, Hibi, Sakuma, Shiina, Takeuchi, Ohnishi, Hirano, Saito: Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. in The Journal of biological chemistry 2001
Show all 2 Pubmed References
Human Polyclonal GAB2 Primary Antibody for IF (p), IHC (p) - ABIN681178
Zhan, Xu, Chen, Wang, Yanfeng, Dan, Zhan, Shi: Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model. in Synapse (New York, N.Y.) 2014
Human Polyclonal GAB2 Primary Antibody for ELISA, WB - ABIN253292
Bentires-Alj, Gil, Chan, Wang, Wang, Imanaka, Harris, Richardson, Neel, Gu: A role for the scaffolding adapter GAB2 in breast cancer. in Nature medicine 2006
Human Polyclonal GAB2 Primary Antibody for IHC, IHC (p) - ABIN4313051
Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. in Molecular & cellular proteomics : MCP 2006
Gab2 is overexpressed in UMs (show TBX3 Antibodies) and plays an important role in UM invasion. Moreover, our findings suggest a novel role for Gab2 in modulating MMP-2 (show MMP2 Antibodies), MMP-9 (show MMP9 Antibodies), and fascin (show FSCN1 Antibodies) expression in regulating the invasion of UM tumor cells
a common locus (rs3740677) in 3' UTR of GAB2 sequence which is targeted by the miRNA-185 was explored the probable associations of rs3740677 with risk for late-onset AD (LOAD) in a large scale case-control study from Chinese Han populations.
we provided evidences to imply that miR (show MLXIP Antibodies)-302c-3p downregulation in human RCC (show XRCC1 Antibodies) cells causes Gab2 over-expression, Akt (show AKT1 Antibodies) hyper-activation and cell proliferation.
study identified that GAB2 as an adaptor protein was preferentially induced in Th2 differentiation and regulated Th2 immune responses
The proto-oncogene (show RAB1A Antibodies) GAB2 (11q14.1) was significantly amplified in non-smokers patients and GAB2 protein was relatively up-regulated in non-smoker than smoker tissues. GAB2 may represent a potential biomarker for lung SCC (show CYP11A1 Antibodies) in non-smokers
There was no significant association between single nucleotide polymorphisms (SNPS) of GAB2 rs2373115 (G > T) and PICALM (show PICALM Antibodies) rs541458 (C > T) and Alzheimer's disease (AD). The allele T of rs3851179 in PICALM (show PICALM Antibodies) was associated with a 13 % increase in the risk of AD. Seven SNPs on SORL1 (show SORL1 Antibodies) were significantly associated with AD.
Results show that up-regulation of Gab2 expression was found to be positively correlated with VEGF (show VEGFA Antibodies) in colorectal cancer (CRC (show CALR Antibodies)) tissues, and suggest that Gab2 promotes intestinal tumor growth and angiogenesis through upregulation of VEGF (show VEGFA Antibodies) expression mediated by the MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies)/c-Myc (show MYC Antibodies) pathway.
The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 and their complexes with Shp2 (show PTPN11 Antibodies). VEGFR2 (show KDR Antibodies) recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2. As Gab2 binds VEGFR2 (show KDR Antibodies) complexes more transiently than Gab1, VEGFR2 (show KDR Antibodies) complexes can recycle and continue to participate in other signaling pathways.
The authors showed that GAB2 is cleaved at G238 during Coxsackievirus type B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676.
Studied BAK1 (show BAK1 Antibodies), SPRY4 (show SPRY4 Antibodies) and GAB2 SNPs in pediatric germ cell tumors(GCT (show QPCT Antibodies)); found a variant in SPRY4 (show SPRY4 Antibodies) was associated with reduced risk of GCT (show QPCT Antibodies); a variant in BAK1 (show BAK1 Antibodies) was positively associated with GCT (show QPCT Antibodies) with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT (show QPCT Antibodies).
The results of this study showed that the reactive Schwann cells exhibit migratory features dependent on the expression of a scaffolding oncoprotein Grb2-associated binder-2 (Gab2), which was transcriptionally induced by neuregulin 1 (show NRG1 Antibodies)-ErbB2 (show ERBB2 Antibodies) signaling following nerve injury.
we demonstrated for the first time that Gab2 deficiency has a profound effect on the course of disease in an in vivo chronic myeloid leukemia (show BCL11A Antibodies) model
High Gab2 expression is associated with myeloproliferative neoplasm.
Gab2 may be a disease-associated protein that is induced by pathogenic factors to amplify and coordinate multifactor-induced signals to govern disease development in the liver.
Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r (show IL4R Antibodies), synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r (show IL4R Antibodies) = interleukin-4 receptor (show IL4R Antibodies))
Given that GAB2 is dispensable for normal hematopoiesis, GAB2 and its effectors PI3K and SHP2 represent promising targets for therapy in Ph(+)hematologic neoplasms
Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
These results define a novel role for Gab2 in mediating mucin (show SLC13A2 Antibodies) gene expression and GCH (show GCH1 Antibodies); these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases.
Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
GRB2-associated binding protein 2
, GRB2-associated-binding protein 2
, Grb2-associated binder 2
, growth factor receptor bound protein 2-associated protein 2
, GRB2-associated binder 2
, Grb2 associated binder 2
, PH domain-containing adaptor molecule p97