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anti-Human ORAI1 Antibodies:
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Human Polyclonal ORAI1 Primary Antibody for ELISA, WB - ABIN449577
Li, Lu, Xu, Xie, Chen, Xu: Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation. in The Journal of biological chemistry 2007
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Human Polyclonal ORAI1 Primary Antibody for IHC (p), WB - ABIN2475964
Weston, Lawrence: An educational strategy for teaching psychosocial pediatrics. in Southern medical journal 1975
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Human Polyclonal ORAI1 Primary Antibody for IHC, ELISA - ABIN1002944
Soboloff, Spassova, Dziadek, Gill: Calcium signals mediated by STIM and Orai proteins--a new paradigm in inter-organelle communication. in Biochimica et biophysica acta 2006
Show all 2 Pubmed References
Human Polyclonal ORAI1 Primary Antibody for IHC, ELISA - ABIN1002945
Feske, Gwack, Prakriya, Srikanth, Puppel, Tanasa, Hogan, Lewis, Daly, Rao: A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. in Nature 2006
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Human Monoclonal ORAI1 Primary Antibody for ELISA, ICC - ABIN4341596
Ávila-Medina, Calderón-Sánchez, González-Rodríguez, Monje-Quiroga, Rosado, Castellano, Ordóñez, Smani: Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells. in The Journal of biological chemistry 2016
Orai1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
The findings identify ORAI1 as an important regulator of cardiac and skeletal muscle function and provide evidence linking ORAI1-mediated calcium signaling to sarcomere integrity and cardiomyocyte function.
The Orai1 actively recycles between an endosomal compartment and the cell membrane through a Rho-dependent endocytic pathway.
STIM1 (show STIM1 Antibodies) and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.
calmodulin (CaM) associates with the core region of STIM1 in a Ca2+-dependent manner. Consequently, calcium-bound CaM disrupts the STIM1-Orai1 complex and disassembles STIM1 oligomers, thereby inducing deactivation of the store-operated calcium entry.
Here, we summarize the recent discoveries on the structure-function relationship of Orai1, as well as its interaction with the native channel opener STIM1 (show STIM1 Antibodies) and chemical modulator 2-aminoethoxydiphenyl borate .
Orai3 (show ORAI3 Antibodies) is associated with poor prognosis of lung adenocarcinoma, predicting metastasis and reduced survival.
These results not only highlight the complex effect of cholesterol regulation on SOCE, but also indicate a direct regulatory effect on Orai1 localization and compartmentalization by this lipid.
Data show that the G98S and V107M mutations generate constitutively permeable ORAI1 channels, whereas T184M alters the channel permeability only in the presence of STIM1 (show STIM1 Antibodies).
Data indicate that the inhibition of the Store Operated Calcium Entry (SOCE)-dependent colon cancer cell migration through SK3 (show KCNN3 Antibodies)/TRPC1 (show TRPC1 Antibodies)/Orai1 channel complex by the alkyl-lipid Ohmline may be a strategy to modulate Anti-EGFR (show EGFR Antibodies) mAb action in metastatic colorectal cancer (mCRC).
Study identifies Orai1 as a novel molecular determinant for oral/oropharyngeal squamous cell carcinoma progression by enhancing cancer stemness.
Healthy individuals and patients with urolithiasis in the Russian population who have the GG genotype and/or the G allele of the polymorphism of the ORAI1 gene (rs7135617) represent risk groups for the formation of calcium oxalate stones.
Orai1 expression is a predictor of 5-Fluorouracil sensitivity for hepatocarcinoma treatment.
Store-operated calcium entry via Orai1 in mesangial cells negatively regulates the TGF-beta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) signaling pathway.
Silencing of beta 1 integrin gene regulates the gene expression of storeoperated Ca2 (show CA2 Antibodies)+ entry (SOCE)-associated genes (STIM1 (show STIM1 Antibodies), ORAI1 (show TMEM132A Antibodies) and TRPC1 (show TRPC1 Antibodies)).
Our study demonstrates that Orai1 (show TMEM132A Antibodies)-Ca(2 (show CA2 Antibodies)+)-calcineurin-NFATc4 (show NFATC4 Antibodies) signaling is an essential inflammatory pathway required for TNFalpha (show TNF Antibodies)-induced endothelial cell activation and vascular inflammation. Therefore, Orai1 (show TMEM132A Antibodies) may be a potential therapeutic target for treatment of inflammatory diseases.
Store-operated calcium entry via Orai1 (show TMEM132A Antibodies) in mesangial cells negatively regulates the TGF-beta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) signaling pathway.
Orai1 (show TMEM132A Antibodies) enhances muscle endurance by promoting fatigue-resistant type I fiber content
findings demonstrate that Ca2 (show CA2 Antibodies)+ influx via store-operated CRAC channels is essential for CaCC (show CLCA1 Antibodies) activation, chloride secretion, and sweat production in humans and mice.
Mouse embryos deficient in Orai1 (show TMEM132A Antibodies), Klf2 (show KLF2 Antibodies), or Klf4 (show KLF4 Antibodies) showed a significantly reduced lymphatic density and impaired lymphatic development.
Store operated calcium entry negatively regulates the Smad1 (show SMAD1 Antibodies) signaling pathway and inhibits Col (show HDAC1 Antibodies) IV protein production in glomerular mesangial cells.
F. vulgare fruits extract and its hexane fraction strongly blocked ORAI1 (show TMEM132A Antibodies) currents and tyrosinase (show TYR Antibodies) activity and significantly inhibited UV-induced melanogenesis
mice lacking acinar Orai1 (show TMEM132A Antibodies) exhibited intestinal bacterial outgrowth and dysbiosis, ultimately causing systemic translocation, inflammation, and death.
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).
ORAI calcium release-activated calcium modulator 1
, calcium release-activated calcium channel protein 1
, protein orai-1
, transmembrane protein 142A
, protein orai-2
, transmembrane protein 142B
, calcium release-activated calcium modulator 1
, calcium release-activated calcium channel 1