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Mep1A (show MEP1A Proteins) is overexpressed in most hepatocellular carcinomas and induces tumor cell migration and invasion. Mep1A (show MEP1A Proteins) expression is regulated by Reptin, and Mep1A (show MEP1A Proteins) mediates Reptin-induced migration.
Reptin silencing did not affect the tyrosine phosphorylation of the insulin receptor (show INSR Proteins) nor of IRS1 (show IRS1 Proteins), but it enhanced the tyrosine phosphorylation of the p85 subunit of PI3K (show PIK3CA Proteins).
Overall, POLG (show POLG Proteins) interactome mapping identifies novel proteins which support mitochondrial biogenesis and a potential novel mitochondrial isoform of Ruvbl2.
The authors report that HIV-1 exploits the host factor RuvB-like 2 (RVB2) to balance relative expression of Gag and Env (show ERVW-1 Proteins) for efficient production of infectious virions.
by means of molecular docking approaches we first modeled the structures of hetero-hexameric TIP49 ( TIP49a and TIP49b )complexes with short ds-DNA fragments (20 base pairs with different GC content) within the central channel of hexameric ring
Data suggest that overexpression of Reptin in hepatocellular carcinoma (HCC (show FAM126A Proteins)) could be a factor of resistance to treatment.
RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.
results reveal a novel mechanism for the control of NF-kappaB (show NFKB1 Proteins) pathway by cytoplasmic Reptin
The results suggests that a potential mechanism for the role of RuvBL1-RuvBL2 in maintaining genome integrity is through controlling the cellular abundance of Fanconi anaemia core complex.
Reptin and Pontin oligomerization and activity are modulated through histone H3 N-terminal tail interaction.
Ruvbl2 has a role in the differentiation of neuroectoderm during early embryogenesis.
accumulating E2f1 (show E2F1 Proteins) progressively recruits a Pontin/Reptin complex to open the chromatin conformation at E2f (show E2F1 Proteins) target genes and amplifies the E2f (show E2F1 Proteins) transcriptional response.
Reptin plays a key role in maintaining the pluripotency of embryonic stem cells and in establishing the pluripotency during reprogramming of somatic cells by regulation of Oct4 (show POU5F1 Proteins)-mediated gene regulation
Gata3 (show GATA3 Proteins)/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c (show CDKN2C Proteins) expression.
We demonstrate that leukemogenic activity of MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) requires RUVBL2 (RuvB-like 2), an AAA (show AAAS Proteins)+ ATPase family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.
A forward genetic screen reveals roles for Nfkbid (show NFKBID Proteins), Zeb1, and Ruvbl2 in humoral immunity.
Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner.
Reptin, a chromatin-remodeling factor (show ASH1L Proteins), is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a (show EHMT2 Proteins).
RuvBl2, which encodes an ATP-dependent DNA helicase, is specifically detected in the spermatocytes and spermatids of the adult testis as well as in primordial germ cells.
RUVBL2 plays an important role in insulin (show INS Proteins)-stimulated GLUT4 (show SLC2A4 Proteins) translocation through its interaction with AS160 (show TBC1D4 Proteins)
the Reptin-Lrrc6/Seahorse (show LRRC6 Proteins) complex is involved in dynein arm formation.
the reptin/pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin (show CTNNB1 Proteins) pathway
xPontin and xReptin are essential genes regulating cell proliferation in early Xenopus embryogenesis through interaction with c-Myc (show MYC Proteins)
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.
48 kDa TATA box-binding protein-interacting protein
, 48 kDa TBP-interacting protein
, 51 kDa erythrocyte cytosolic protein
, INO80 complex subunit J
, RuvB (E coli homolog)-like 2
, TIP60-associated protein 54-beta
, erythrocyte cytosolic protein, 51-KD
, repressing pontin 52
, reptin52 protein
, ruvB-like 2
, RuvB-like protein 2
, RuvB-like 2
, RuvB-like 2 (E. coli)
, ruvB-like 2-like
, ruvb-like 2
, ruvB-like helicase 2