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anti-Human TSH receptor Antibodies:
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Human Monoclonal TSH receptor Primary Antibody for FACS, IHC (p) - ABIN2476797
Costagliola, Rodien, Many, Ludgate, Vassart: Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor. in Journal of immunology (Baltimore, Md. : 1950) 1998
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Human Monoclonal TSH receptor Primary Antibody for IHC (p) - ABIN535220
Mizukami, Hashimoto, Nonomura, Michigishi, Nakamura, Noguchi, Matsukawa: Immunohistochemical demonstration of thyrotropin (TSH)-receptor in normal and diseased human thyroid tissues using monoclonal antibody against recombinant human TSH-receptor protein. in The Journal of clinical endocrinology and metabolism 1994
Show all 3 Pubmed References
Cow (Bovine) Polyclonal TSH receptor Primary Antibody for WB - ABIN2777037
Claus, Jaeschke, Kleinau, Neumann, Krause, Paschke: A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling. in Endocrinology 2005
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Functional thyroid differentiation in zebrafish was examined and the role of TSHR signaling during thyroid organogenesis, was characterized.
TSHR mutations occur in approximately 5% thyroid nodules in a large consecutive series with indeterminate cytology. TSHR mutations may be associated with an increased cancer risk when present at high allelic frequency
This work is devoted to the ascertainment of serological cross-reactivity between OmpF porin (show VDAC1 Antibodies) from Yersinia pseudotuberculosis (YpOmpF) and human thyroid-stimulating hormone receptor (hTSHR).
Genetic polymorphisms of CTLA-4 gene on the nucleotide 49 at codon 17 of exon 1, TSHR gene SNP rs2268458 of intron 1, number of regulatory T cells and TRAb levels play a role as risk factors for relapse in patients with Graves' disease.
Overexpression of TSHR was found in a great majority of hepatocellular carcinomatissues and associated with unfavorable prognosis
Signaling dissection using diverse inhibitors indicated that EOC cell proliferation driven by thyrostimulin (show GPHa2 Antibodies)-TSHR signaling is PKA independent, but does require the involvement of the MEK (show MAP2K1 Antibodies)-ERK (show EPHB2 Antibodies) and PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) signal cascades, which are activated mainly via the trans-activation of EGFR (show EGFR Antibodies)
Among the evaluated TSHR gene SNPs, the rs4411444 GG genotype and the rs4903961 C allele in the enhancer regions of the TSHR gene were most strongly associated with the development of Graves disease, especially intractable disease, and that of Hashimoto disease, respectively.
Low expression of TSHR is associated with dilated cardiomyopathy and impaired left ventricular function accompanied by increased risk of death.
Data suggest iodination of TG is involved in regulation of NIS expression in thyroid follicle via TSH/TSHR signaling; NIS expression and PKA activity are up-regulated by lowly iodinated TG; NIS expression is down-regulated and PKC (show PRRT2 Antibodies) activity up-regulated by highly iodinated TG. (TG, thyroglobulin (show TG Antibodies); NIS, sodium/iodide symporter; PK, protein kinase (show CDK7 Antibodies); TSH, thyroid-stimulating hormone; TSHR, thyroid-stimulating hormone receptor)
Monoallelic TSHR mutations are significantly associated with positive newborn screen for congenital hypothyroidism, and the association is further strengthened by the coexistence of monoallelic DUOX2 (show DUOX2 Antibodies) mutations.
findings proved that iodinated TG in thyroid follicular lumen regulated TTF-1 and PAX8 expression through thyroid stimulating hormone/thyroid stimulating hormone receptor (TSH/TSHR) mediated cAMP-PKA and PLC-PKC signaling pathways.
Data suggest that stimulation of Tsh/Tshr signaling increases apoptosis and suppresses autophagy in primary chondrocytes.
Unlike its critical role in maintaining the normal growth and function of the thyroid gland, our results demonstrated that hepatic TSHR is involved in liver lipid metabolism and has little effect on energy metabolism.
Data indicate that splenic T cells from thyroid stimulating hormone receptor (TSHR) A-subunit primed animals undergoing Graves' orbitopathy (GO) showed proliferative responses to purified TSHR antigen and secreted proinflammatory cytokines.
Lung fibroblasts of TSHR KO mice have decreased cell surface Igf1r (show IGF1R Antibodies) expression, and have Igf1r (show IGF1R Antibodies) protein and protein fragments in both cytoplasm and nucleus. Igf1r (show IGF1R Antibodies) mRNA levels were similar between TSHR KO and WT mice.
The mechanism, underlying TSH-induced liver triglyceride accumulation, involved that TSH, through its receptor TSHR, triggered hepatic SREBP-1c (show SREBF1 Antibodies) activity.
These findings suggest that activation of TSHR directly inhibits FASN (show FASN Antibodies) expression in mature adipocytes, possibly mediated by PKA and ERK (show EPHB2 Antibodies)
A novel role for TSHR in behavioral and neurological phenotypes of Attention deficit/hyperactivity disorder.
The data indicate functional TSHR is expressed in ventricular myocytes and mediates TSH-induced BNP (show BNC2 Antibodies) secretion and HMGCR (show HMGCR Antibodies) up-regulation through the cAMP/PKA/pCREB signaling pathway.
findings demonstrate TSH-R expression is thymus-specific within the immune system; data support the notion of a novel neuroendocrine-immune interaction in which TSH-R signaling in the thymus, most likely mediated by TSH, enhances thymic T-cell development
The inhibition of hepatic PEPCK (show PEPCK Antibodies) and G6P and enhanced expression of GK contributed to the development of fasting hypoglycemia in Tshr-ko mice.
Localization of thyrotropin receptor and thyroglobulin (show TG Antibodies) in the bovine corpus luteum.
analysis of activation switch in the thyrotropin receptor
Rhes (show RASD2 Antibodies) can interfere with the functional activity of wt and mutated TSHr.
Increased receptor binding by bovine (b) TSH bound to monoclonal antibody to bTSHbeta-subunit.
the hinge region represents an extracellular intermediate connector for both hormone binding and signal transduction of the thyroid stimulating hormone receptor
The equine TSHR is not responsive to equine chorionic gonadotropin but is more sensitive to human CG than the human TSHR
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
, thyroid-stimulating hormone receptor
, thyrotropin receptor
, seven transmembrane helix receptor
, thyrotropin receptor-I, hTSHR-I