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The observations suggest that MD-2 helps to regulate lipopolysaccharide-induced NLRP3 (show NLRP3 ELISA Kits) inflammasome activation and the inflammatory response in NR8383 cells, and likely does so by affecting MyD88 (show MYD88 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signaling.
MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases.
we report that exogenous CnB (show PPP3R1 ELISA Kits) is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (show TLR4 ELISA Kits)/MD2 complex together with the co-receptor CD14 (show NDUFA2 ELISA Kits)
In this study, a novel naturally occurring spliceosome of human MD2, termed as MD2-T3, has been identified.
Results show that cigarette smoke may alter innate immune responses reducing the expression of the MD2, a molecule with an important role in TLR4 (show TLR4 ELISA Kits) signaling.
Predominantly hydrophobic interactions between MD-2 and TLR4 (show TLR4 ELISA Kits) contribute to the stabilization of the TLR4 (show TLR4 ELISA Kits)/MD-2/metal ion complex in a conformation that enables activation.
The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 (show TLR4 ELISA Kits) ligands may be facilitated through synthesis and release of sMD2 (show SNRPD2 ELISA Kits) by the amniochorion.
Three genes (LY96, IL8 (show IL8 ELISA Kits) DPR (show DACT1 ELISA Kits)) were significantly downregulated over time. This finding was confirmed in a validation cohort of stroke patients (n=8).
The study revealed the impact of specific residues and regions of MD-2 on the binding of lipolysaccharides and TLR4 (show TLR4 ELISA Kits).
Gene polymorphisms of MD2 and GM2A (show GM2A ELISA Kits) were associated with the occurrence or severity of neonatal necrotizing enterocolitis.
Data suggest that C4bp prevents interaction between Tlr4 (show TLR4 ELISA Kits)/MD-2 and its ligand; C4bp does not appear to interact with Tlr3 (show TLR3 ELISA Kits); C4bp binds to macrophage surface Tlr4 (show TLR4 ELISA Kits) and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 (show TLR4 ELISA Kits) activation. (C4bp = complement component 4 binding protein; Tlr = toll (show TLR4 ELISA Kits)-like receptor; MD-2 = myeloid differentiation protein-2)
Oxidative stress in retinal ischemia-reperfusion injury activates TLR4 (show TLR4 ELISA Kits) signaling via MD2.
Neoseptin-3 and lipid A form dissimilar molecular contacts to achieve receptor activation; hence strong TLR4 (show TLR4 ELISA Kits)/MD-2 agonists need not mimic LPS (show TLR4 ELISA Kits)
Here we demonstrate that cholesterol binds to myeloid differentiation-2 (MD-2), a TLR4 (show TLR4 ELISA Kits) ancillary molecule.
MD-2 is a critical regulator of the establishment of allergic airway sensitization to HDM (show HDAC3 ELISA Kits) in mice. Serum MD-2 may represent a potential biomarker for the amplification of allergic sensitization and allergic inflammation.
Data show that myeloid differentiation factor 2 (MD-2) binds specifically to disulfide isoform of box protein 1, high mobility group (show SSRP1 ELISA Kits) (HMGB1 (show HMGB1 ELISA Kits)) to facilitate toll-like receptor 4 (TLR4 (show TLR4 ELISA Kits))-dependent signaling.
Carbon monoxide treatment reduces the expression of the TLR4 (show TLR4 ELISA Kits)/MD2 complex on the surface of myeloid cells, which renders them resistant to lipopolysaccharide priming in vitro, as well as in vivo in a model of endotoxic shock.
Mechanistically, engagement of MD-2 by PTX3 (show PITX3 ELISA Kits)-opsonized Aspergillus conidia activated the TLR4/Toll (show TLR4 ELISA Kits)/IL-1R domain-containing adapter inducing IFN-beta (show IFNB1 ELISA Kits)-dependent signaling pathway converging on IL-10 (show IL10 ELISA Kits).
SAA3 (show SAA3 ELISA Kits) directly binds MD-2 and activates the MyD88 (show MYD88 ELISA Kits)-dependent TLR4 (show TLR4 ELISA Kits)/MD-2 pathway.
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms.
myeloid differentiation protein-2
, protein MD-2
, myeloid differentiation factor-2
, LPS co-receptor MD-2
, lymphocyte antigen 96
, Protein MD-2