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Human Polyclonal TLR7 Primary Antibody for FACS, ICC - ABIN4360352
Palazzo, Gariboldi, Zanobbio, Dusio, Selleri, Bedoni, Balsari, Rumio: Cross-talk among Toll-like receptors and their ligands. in International immunology 2008
Show all 43 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS, ICC - ABIN4360350
Kalali, Köllisch, Mages, Müller, Bauer, Wagner, Ring, Lang, Mempel, Ollert: Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 20 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS - ABIN4360348
Xirakia, Koltsida, Stavropoulos, Thanassopoulou, Aidinis, Sideras, Andreakos: Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma. in American journal of respiratory and critical care medicine 2010
Show all 18 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS, IHC (fro) - ABIN252541
Chen, Nagaraju, Bakay, McIntyre, Rawat, Shi, Hoffman: Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy. in Neurology 2005
Show all 12 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS - ABIN4360345
Lee, Wu, Lee, Chuang, Katakura, Liu, Chan, Tawatao, Chung, Shen, Cottam, Lai, Raz, Carson: Activation of anti-hepatitis C virus responses via Toll-like receptor 7. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 11 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS - ABIN4360344
Wong, Cheung, Ip, Lam: Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. in American journal of respiratory cell and molecular biology 2007
Show all 10 Pubmed References
Human Polyclonal TLR7 Primary Antibody for IHC (p), WB - ABIN4360334
Tengroth, Millrud, Kvarnhammar, Kumlien Georén, Latif, Cardell: Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells. in PLoS ONE 2014
Show all 4 Pubmed References
Human Monoclonal TLR7 Primary Antibody for FACS - ABIN4897510
Ma, Ni, Zhang, Zhang, Wu, Atia, Thayer, Moorman, Yao: PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection. in Immunology 2011
Show all 4 Pubmed References
Human Monoclonal TLR7 Primary Antibody for CyTOF, FACS - ABIN4360357
Lehmann, Krüger, Park, Derkow, Rosenberger, Baumgart, Trimbuch, Eom, Hinz, Kaul, Habbel, Kälin, Franzoni, Rybak, Nguyen, Veh, Ninnemann, Peters, Nitsch, Heppner, Golenbock, Schott, Ploegh, Wulczyn et al.: An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. ... in Nature neuroscience 2012
Show all 4 Pubmed References
Human Monoclonal TLR7 Primary Antibody for CyTOF, FACS - ABIN4360354
Chauhan, Singh, Rai, Rai, Rai: Distinct autoantibody profiles in systemic lupus erythematosus patients are selectively associated with TLR7 and TLR9 upregulation. in Journal of clinical immunology 2013
Show all 3 Pubmed References
Btk (show BTK Antibodies) acts in the TLR7/8 pathway and mediates Ser (show SIGLEC1 Antibodies)-536 phosphorylation of p65 RelA (show NFkBP65 Antibodies) and subsequent nuclear entry in primary human macrophages.
the miRNA profile did not significantly differ between SLE and APS (show SH2B2 Antibodies), but was driven by the presence or absence of an IFN signature. TLR7 stimulation induced a general downregulation of miRNAs, similar to the pattern observed in SLE and APS (show SH2B2 Antibodies) patients.
TLR7 upregulation has a role in liver cancer cell proliferation involving lipid rafts
Study demonstrates that Hepatitis C virus (HCV) genomic RNA harbours specific sequences that initiate an anti-HCV immune response through TLR7 and TLR8 (show TLR8 Antibodies) in various antigen presenting cells.
TLR7, TLR9 (show TLR9 Antibodies), and JAK2 (show JAK2 Antibodies) genes are potential biomarkers for systemic sclerosis. High TLR7 expression positively correlated with the late form of disease. Decreased levels of TLR9 (show TLR9 Antibodies) and JAK2 (show JAK2 Antibodies) mRNA were found in the patient's cohort in comparison to non-SSc (show CYP11A1 Antibodies) individuals.
The results indicate that TLR7 up-regulation is related to Respiratory syncytial virus infection and the induction of oxidative stress and that TLR7 expression was mediated by the anti-inflammatory effects of Nrf2 (show GABPA Antibodies)/ARE pathway inhibitors or agonists.
Thus, TLR7 and TLR8 (show TLR8 Antibodies) might modulate different immune responses in monocytes and macrophages.
Positive rates of iNOS (show NOS2 Antibodies) in cervical tissues were 72.1%, 28.2%, and 3.1% in the -HPV-positive patients with cervical cancer (CC group), HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3 (show TLR3 Antibodies), TLR4 (show TLR4 Antibodies), TLR7, TLR8 (show TLR8 Antibodies), NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies), and iNOS (show NOS2 Antibodies) in cervical epithelial cells were higher in CC group than in other groups.
Data suggest a central role of XBP1 (show XBP1 Antibodies) in TLR7-induced IFNalpha production and identify XBP1 (show XBP1 Antibodies) as a potential novel therapeutic target in IFNalpha-driven autoimmune and inflammatory diseases.
These findings suggest that increased EV71 and CA16 replication meditated by autophagy in 16HBE cells might promote degradation of the endosome, leading to suppression of the TLR7-mediated IFN-I signaling pathway.
Results suggest that toll-like receptor 7 (TLR7) needs to move to the cell periphery to induce robust type I interferon responses in plasmacytoid dendritic cells (pDC (show PDC Antibodies)).
The results demonstrate that TLR7 activation may trigger innate immunity pathways and induce apoptosis and hypoplasia of neonatal biliary trees in Balb/c mice. The novel findings give an implication of pathogenesis of infantile cholestasis, such as biliary atresia.
TLR7 deletion reduces atherosclerosis in apolipoprotein E (show APOE Antibodies)-deficient mice.
SZU-101 enhances tumor clearance in vivo, without affecting the TLR7-NF-kappaB (show NFKB1 Antibodies) pathway activated by the TLR7 agonist in mouse spleen lymphocytes and bone marrow dendritic cells
Up-regulation of TLR7 could eliminate intracellular Mtb (show NCAPG2 Antibodies) through autophagy
conclude that VDD promotes tumor growth in the context of Smad3 (show SMAD3 Antibodies) disruption, potentially through regulation of TLR7 expression and beta-catenin (show CTNNB1 Antibodies) activation
activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder
Here, we show that under these circumstances, the Toll (show TLR4 Antibodies)-like receptor (TLR)-7/8 ligand imiquimod, but not the TLR3 (show TLR3 Antibodies) ligand poly I:C or TLR9 (show TLR9 Antibodies) ligand CpG, mediated an effective antitumor response. The rejection of these immune-escaped cancers was mediated by NK cells and CD4 (show CD4 Antibodies)(+) T cells, whereas activated CD8 (show CD8A Antibodies)(+) T cells were dispensable
TLR7 prevents progression of non-alcoholic fatty liver disease via induced autophagy and released IGF-1 (show IGF1 Antibodies) from liver. These findings suggest a new therapeutic strategy for the treatment of NAFLD (show TSC2 Antibodies).
Toll-like receptor 2 (TLR2) controls random motility, while Toll-like receptor 7 (TLR7) regulates chemotaxis of microglial cells via distinct pathways. Furthermore, TLR7 mRNA expression is down-regulated by TLR2 and TLR7 activation.
TLR7 stimulation of Bovine Viral Diarrhea Virus Type 2-infected monocyte-derived macrophages induced cytokine secretion, unlike results observed for other Toll (show TLR4 Antibodies)-Like Receptors.
The results from this study demonstrate that expression of at least TLR3 (show TLR3 Antibodies), TLR7 and TLR8 (show TLR8 Antibodies) is stimulated upon bovine alpha-herpesvirus infection of the brain.
The messenger RNA sequences and exon/intron structures of Toll (show TLR4 Antibodies)-like receptors 3, 7, and 8 were determined.
expression of TLR3 (show TLR3 Antibodies), TLR7 and TLR9 (show TLR9 Antibodies) in alveolar macrophages infected with different genotype 1 PRRSV strains
Porcine TLR7 and TLR8 (show TLR8 Antibodies) genes from pig lymph node tissue, were cloned and characterized.
A total of 22 polymorphic sites were observed in TLR7 gene of 24 goats representing 12 different breeds, out of which 19 were present within the coding region and three in 3'UTR (show UTS2R Antibodies).
Activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
toll-like receptor 7-like
, toll like receptor 7
, toll-like receptor 7-long