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Human Polyclonal TLR7 Primary Antibody for FACS, ICC - ABIN4360352
Palazzo, Gariboldi, Zanobbio, Dusio, Selleri, Bedoni, Balsari, Rumio: Cross-talk among Toll-like receptors and their ligands. in International immunology 2008
Show all 43 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS, ICC - ABIN4360350
Kalali, Köllisch, Mages, Müller, Bauer, Wagner, Ring, Lang, Mempel, Ollert: Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 20 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS - ABIN4360348
Xirakia, Koltsida, Stavropoulos, Thanassopoulou, Aidinis, Sideras, Andreakos: Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma. in American journal of respiratory and critical care medicine 2010
Show all 18 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS, IHC (fro) - ABIN252541
Chen, Nagaraju, Bakay, McIntyre, Rawat, Shi, Hoffman: Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy. in Neurology 2005
Show all 12 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS - ABIN4360345
Lee, Wu, Lee, Chuang, Katakura, Liu, Chan, Tawatao, Chung, Shen, Cottam, Lai, Raz, Carson: Activation of anti-hepatitis C virus responses via Toll-like receptor 7. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 11 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS - ABIN4360344
Wong, Cheung, Ip, Lam: Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. in American journal of respiratory cell and molecular biology 2007
Show all 10 Pubmed References
Human Polyclonal TLR7 Primary Antibody for IHC (p), WB - ABIN4360334
Tengroth, Millrud, Kvarnhammar, Kumlien Georén, Latif, Cardell: Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells. in PLoS ONE 2014
Show all 4 Pubmed References
Human Monoclonal TLR7 Primary Antibody for CyTOF, FACS - ABIN4360357
Lehmann, Krüger, Park, Derkow, Rosenberger, Baumgart, Trimbuch, Eom, Hinz, Kaul, Habbel, Kälin, Franzoni, Rybak, Nguyen, Veh, Ninnemann, Peters, Nitsch, Heppner, Golenbock, Schott, Ploegh, Wulczyn et al.: An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. ... in Nature neuroscience 2012
Show all 4 Pubmed References
Human Monoclonal TLR7 Primary Antibody for FACS - ABIN4897510
Ma, Ni, Zhang, Zhang, Wu, Atia, Thayer, Moorman, Yao: PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection. in Immunology 2011
Show all 4 Pubmed References
Human Monoclonal TLR7 Primary Antibody for CyTOF, FACS - ABIN4360354
Chauhan, Singh, Rai, Rai, Rai: Distinct autoantibody profiles in systemic lupus erythematosus patients are selectively associated with TLR7 and TLR9 upregulation. in Journal of clinical immunology 2013
Show all 3 Pubmed References
TLR7 upregulation has a role in liver cancer cell proliferation involving lipid rafts
Study demonstrates that Hepatitis C virus (HCV) genomic RNA harbours specific sequences that initiate an anti-HCV immune response through TLR7 and TLR8 (show TLR8 Antibodies) in various antigen presenting cells.
TLR7, TLR9 (show TLR9 Antibodies), and JAK2 (show JAK2 Antibodies) genes are potential biomarkers for systemic sclerosis. High TLR7 expression positively correlated with the late form of disease. Decreased levels of TLR9 (show TLR9 Antibodies) and JAK2 (show JAK2 Antibodies) mRNA were found in the patient's cohort in comparison to non-SSc (show CYP11A1 Antibodies) individuals.
The results indicate that TLR7 up-regulation is related to Respiratory syncytial virus infection and the induction of oxidative stress and that TLR7 expression was mediated by the anti-inflammatory effects of Nrf2 (show GABPA Antibodies)/ARE pathway inhibitors or agonists.
Thus, TLR7 and TLR8 (show TLR8 Antibodies) might modulate different immune responses in monocytes and macrophages.
Positive rates of iNOS (show NOS2 Antibodies) in cervical tissues were 72.1%, 28.2%, and 3.1% in the -HPV-positive patients with cervical cancer (CC group), HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3 (show TLR3 Antibodies), TLR4 (show TLR4 Antibodies), TLR7, TLR8 (show TLR8 Antibodies), NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies), and iNOS (show NOS2 Antibodies) in cervical epithelial cells were higher in CC group than in other groups.
Data suggest a central role of XBP1 (show XBP1 Antibodies) in TLR7-induced IFNalpha production and identify XBP1 (show XBP1 Antibodies) as a potential novel therapeutic target in IFNalpha-driven autoimmune and inflammatory diseases.
These findings suggest that increased EV71 and CA16 replication meditated by autophagy in 16HBE cells might promote degradation of the endosome, leading to suppression of the TLR7-mediated IFN-I signaling pathway.
The present study investigated the effects of vitamin D3 on the expression of TLR3 (show TLR3 Antibodies), TLR7, and TLR9 (show TLR9 Antibodies) in Systemic lupus erythematosus patients.
Data suggest that IRAK4 (show IRAK4 Antibodies) activity regulates activation of IRF5 (show IRF5 Antibodies), TAK1 (show MAP3K7 Antibodies), and IKKB (show IKBKB Antibodies) in monocytes; IRAK4 (show IRAK4 Antibodies) activation of TAK1 (show MAP3K7 Antibodies)-IKKB (show IKBKB Antibodies)-IRF5 (show IRF5 Antibodies) axis leads to induction of cytokines and interferons following TLR7/TLR8 (show TLR8 Antibodies) stimulation. (IRAK4 (show IRAK4 Antibodies) = interleukin-1 receptor-associated kinase 4 (show IRAK4 Antibodies); IRF5 (show IRF5 Antibodies) = interferon regulatory factor-5 (show IRF5 Antibodies); TAK1 (show MAP3K7 Antibodies) = MAPK (show MAPK1 Antibodies) kinase kinase 7; IKKB (show IKBKB Antibodies) = I-kappa B kinase; TLR = toll (show TLR4 Antibodies)-like receptor)
Up-regulation of TLR7 could eliminate intracellular Mtb (show NCAPG2 Antibodies) through autophagy
conclude that VDD promotes tumor growth in the context of Smad3 (show SMAD3 Antibodies) disruption, potentially through regulation of TLR7 expression and beta-catenin (show CTNNB1 Antibodies) activation
activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder
Here, we show that under these circumstances, the Toll (show TLR4 Antibodies)-like receptor (TLR)-7/8 ligand imiquimod, but not the TLR3 (show TLR3 Antibodies) ligand poly I:C or TLR9 (show TLR9 Antibodies) ligand CpG, mediated an effective antitumor response. The rejection of these immune-escaped cancers was mediated by NK cells and CD4 (show CD4 Antibodies)(+) T cells, whereas activated CD8 (show CD8A Antibodies)(+) T cells were dispensable
TLR7 prevents progression of non-alcoholic fatty liver disease via induced autophagy and released IGF-1 (show IGF1 Antibodies) from liver. These findings suggest a new therapeutic strategy for the treatment of NAFLD (show TSC2 Antibodies).
Toll-like receptor 2 (TLR2) controls random motility, while Toll-like receptor 7 (TLR7) regulates chemotaxis of microglial cells via distinct pathways. Furthermore, TLR7 mRNA expression is down-regulated by TLR2 and TLR7 activation.
results provide evidence that G, dG, 8-OHG and 8-OHdG are novel endogenous ligands for TLR7.
these data demonstrate that TLR7/TLR9 (show TLR9 Antibodies) ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state.
Virus infection activates endosomal NOX2 (show CYBB Antibodies) oxidase and restricts TLR7 signaling, and that an endosomal NOX2 (show CYBB Antibodies) inhibitor decreases viral pathogenicity.
the JAK (show JAK3 Antibodies)-STAT (show STAT1 Antibodies) pathway provides a cytokine rheostat mechanism, which enables macrophages to fine-tune their responses to multiple, temporally separated infection events involving the TLR3 (show TLR3 Antibodies) and TLR7 pathways.
TLR7 stimulation of Bovine Viral Diarrhea Virus Type 2-infected monocyte-derived macrophages induced cytokine secretion, unlike results observed for other Toll (show TLR4 Antibodies)-Like Receptors.
The results from this study demonstrate that expression of at least TLR3 (show TLR3 Antibodies), TLR7 and TLR8 (show TLR8 Antibodies) is stimulated upon bovine alpha-herpesvirus infection of the brain.
The messenger RNA sequences and exon/intron structures of Toll (show TLR4 Antibodies)-like receptors 3, 7, and 8 were determined.
expression of TLR3 (show TLR3 Antibodies), TLR7 and TLR9 (show TLR9 Antibodies) in alveolar macrophages infected with different genotype 1 PRRSV strains
Porcine TLR7 and TLR8 (show TLR8 Antibodies) genes from pig lymph node tissue, were cloned and characterized.
A total of 22 polymorphic sites were observed in TLR7 gene of 24 goats representing 12 different breeds, out of which 19 were present within the coding region and three in 3'UTR (show UTS2R Antibodies).
Activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
toll-like receptor 7-like
, toll like receptor 7
, toll-like receptor 7-long