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Human Polyclonal TLR7 Primary Antibody for FACS, ICC - ABIN4360352
Palazzo, Gariboldi, Zanobbio, Dusio, Selleri, Bedoni, Balsari, Rumio: Cross-talk among Toll-like receptors and their ligands. in International immunology 2008
Show all 51 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS, ICC - ABIN4360350
Kalali, Köllisch, Mages, Müller, Bauer, Wagner, Ring, Lang, Mempel, Ollert: Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 20 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS - ABIN4360348
Xirakia, Koltsida, Stavropoulos, Thanassopoulou, Aidinis, Sideras, Andreakos: Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma. in American journal of respiratory and critical care medicine 2010
Show all 18 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS, IHC (fro) - ABIN252541
Chen, Nagaraju, Bakay, McIntyre, Rawat, Shi, Hoffman: Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy. in Neurology 2005
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Human Polyclonal TLR7 Primary Antibody for FACS - ABIN4360345
Lee, Wu, Lee, Chuang, Katakura, Liu, Chan, Tawatao, Chung, Shen, Cottam, Lai, Raz, Carson: Activation of anti-hepatitis C virus responses via Toll-like receptor 7. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 11 Pubmed References
Human Polyclonal TLR7 Primary Antibody for FACS - ABIN4360344
Wong, Cheung, Ip, Lam: Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. in American journal of respiratory cell and molecular biology 2007
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Human Monoclonal TLR7 Primary Antibody for CyTOF, FACS - ABIN4360357
Lehmann, Krüger, Park, Derkow, Rosenberger, Baumgart, Trimbuch, Eom, Hinz, Kaul, Habbel, Kälin, Franzoni, Rybak, Nguyen, Veh, Ninnemann, Peters, Nitsch, Heppner, Golenbock, Schott, Ploegh, Wulczyn et al.: An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. ... in Nature neuroscience 2012
Show all 6 Pubmed References
Human Polyclonal TLR7 Primary Antibody for IHC (fro), FACS - ABIN537535
Palladino, Johnson, Gupta, Chapman, Ojha: Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract. in Biology of reproduction 2007
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Human Monoclonal TLR7 Primary Antibody for FACS - ABIN4897510
Ma, Ni, Zhang, Zhang, Wu, Atia, Thayer, Moorman, Yao: PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection. in Immunology 2011
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Human Polyclonal TLR7 Primary Antibody for IHC (p), WB - ABIN4360334
Tengroth, Millrud, Kvarnhammar, Kumlien Georén, Latif, Cardell: Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells. in PLoS ONE 2014
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The C allele is protective of chronic hepatitis C virus (HCV) infection in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.
these results indicated that TLR7 polymorphisms play an important role in disease susceptibility and the progression of chronic hepatitis B infections in Chinese adults, and may partly explain the high incidence of HBV related diseases in Chinese men.
Testing permutations of the nucleobase at ribose-methylated position 54 suggested that the extent of silencing and antagonism of the TLR7 response was governed by hydrogen patterns and lipophilic interactions of the nucleobase. The results identify a new immune-modulatory endogenous RNA modification that limits TLR7 activation by RNA
Study of TLR3 rs3775290, TLR7 rs17900 and TLR9 rs352140 SNPs in chronic hepatitis C (HCV) Egyptian patient cohort revealed that only heterozygous CT genotype of TLR3 rs3775290 may be a susceptibility risk factor for chronic HCV infection and the homozygous CC and the combined CC-AT-GA female genotypes may be protective.
Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NF-kappaB/c-Myc signaling in female esophageal carcinoma.
TLR7 agonist promoted CD8(+) T cells function from breast cancer patients
In female patients with HIV/HCV-coinfection, HIV-monoinfection, chronic hepatitis C, and healthy individuals the TLR7 gene Leu polymorphic allele is recorded by 2.1-3.6 times more frequently than in male patients
Results of a study compared Spanish psoriasis patient and healthy controls showed significant associations between functional TLR3, TLR7 and TLR9 single nucleotide polymorphisms and psoriatic arthritis, earlier disease onset and a greater risk for psoriasis.
This study demonstrated that the rs3853839 C allele of the TLR-7 gene was also a risk factor for severe Hand, Foot, and Mouth Disease (HFMD) in both male and female patients. The A allele at the rs179019 locus of the TLR-7 gene was not risk factors for severe HFMD in either male or female patients.
SOCS1/3-mediated degradation of IFN regulatory factor 7 directly regulates TLR7 signaling and type I IFN production in pDCs.
Systemic lupus erythematosus CXCR5(-) CD11c(+) B cells (DN2) are hyper-responsive to Toll-like receptor-7 signaling.
the authors provide an overview on the contribution of TLR7 and TLR9 to autoimmune diseases and discuss recent findings indicating a pivotal role for these two receptors, along with Epstein-Barr virus, in driving, perpetuating, and/or amplifying intrathymic B cell dysregulation and autoimmune responses in myasthenia gravis.
the polymorphisms in TLR7 and TLR9 are associated with asthma-related phenotypes and asthma risk in the study population.
Lower copy number (=1) of TLR7 gene confers a risk factor for ankylosing spondylitis susceptibility in Chinese males but protective factor in Chinese females.
variations in TLR7 and TLR8 genes modulate the clearance and progression of HCV infection with different magnitudes between sexes
Enhanced TLR7 expression owing to biallelism contributes to the higher risk of developing SLE.
Btk acts in the TLR7/8 pathway and mediates Ser-536 phosphorylation of p65 RelA and subsequent nuclear entry in primary human macrophages.
the miRNA profile did not significantly differ between SLE and APS, but was driven by the presence or absence of an IFN signature. TLR7 stimulation induced a general downregulation of miRNAs, similar to the pattern observed in SLE and APS patients.
TLR7 upregulation has a role in liver cancer cell proliferation involving lipid rafts
Study demonstrates that Hepatitis C virus (HCV) genomic RNA harbours specific sequences that initiate an anti-HCV immune response through TLR7 and TLR8 in various antigen presenting cells.
data demonstrate an interplay between TLR7 signaling and unfolded protein response and indicate that Pin1 modulates these processes during eosinophil development
TLR7 and TLR9 specify monocyte fate and identify a specialized population of phagocytes responsible for anemia and thrombocytopenia associated with inflammation and infection.
The activation of TLR8, TLR7, or TLR3 results in dendritic shortening, and TLR7 and TLR3 but not TLR8 also control axonal growth.
Development of TLR7-driven lupus nephritis was not abolished by the deletion of IL-1beta.
Study data clearly demonstrate a specific role for Tlr7 signaling in local and systemic natural killer cell activation following respiratory Influenza A virus (IAV) infection despite the presence of redundant innate IAV-recognition pathways.
Th17-associated cytokines through NF-kappaB and toll-like receptor 7 (TLR7) signaling.
Results suggest that toll-like receptor 7 (TLR7) needs to move to the cell periphery to induce robust type I interferon responses in plasmacytoid dendritic cells (pDC).
The results demonstrate that TLR7 activation may trigger innate immunity pathways and induce apoptosis and hypoplasia of neonatal biliary trees in Balb/c mice. The novel findings give an implication of pathogenesis of infantile cholestasis, such as biliary atresia.
TLR7 deletion reduces atherosclerosis in apolipoprotein E-deficient mice.
SZU-101 enhances tumor clearance in vivo, without affecting the TLR7-NF-kappaB pathway activated by the TLR7 agonist in mouse spleen lymphocytes and bone marrow dendritic cells
Up-regulation of TLR7 could eliminate intracellular Mtb through autophagy
conclude that VDD promotes tumor growth in the context of Smad3 disruption, potentially through regulation of TLR7 expression and beta-catenin activation
activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder
Here, we show that under these circumstances, the Toll-like receptor (TLR)-7/8 ligand imiquimod, but not the TLR3 ligand poly I:C or TLR9 ligand CpG, mediated an effective antitumor response. The rejection of these immune-escaped cancers was mediated by NK cells and CD4(+) T cells, whereas activated CD8(+) T cells were dispensable
TLR7 prevents progression of non-alcoholic fatty liver disease via induced autophagy and released IGF-1 from liver. These findings suggest a new therapeutic strategy for the treatment of NAFLD.
Toll-like receptor 2 (TLR2) controls random motility, while Toll-like receptor 7 (TLR7) regulates chemotaxis of microglial cells via distinct pathways. Furthermore, TLR7 mRNA expression is down-regulated by TLR2 and TLR7 activation.
results provide evidence that G, dG, 8-OHG and 8-OHdG are novel endogenous ligands for TLR7.
these data demonstrate that TLR7/TLR9 ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state.
Virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogenicity.
the JAK-STAT pathway provides a cytokine rheostat mechanism, which enables macrophages to fine-tune their responses to multiple, temporally separated infection events involving the TLR3 and TLR7 pathways.
On day 104 of pregnancy, mRNA expression of TLRs 3 and 8, as well as that of TLRs 7 and 9, was high in the spleen of fetuses from Neospora caninum-infected heifers. Gene expression levels of endosomal TLRs were also detectable in the placenta and the maternal caruncle from infected heifers, being TLRs 3, 7 and 8 particularly upregulated, mostly in the caruncle.
TLR7 stimulation of Bovine Viral Diarrhea Virus Type 2-infected monocyte-derived macrophages induced cytokine secretion, unlike results observed for other Toll-Like Receptors.
The results from this study demonstrate that expression of at least TLR3, TLR7 and TLR8 is stimulated upon bovine alpha-herpesvirus infection of the brain.
Comparative sequence analysis revealed a total of 139 polymorphisms, which include single-nucleotide polymorphisms and insertion-deletion polymorphisms.
The messenger RNA sequences and exon/intron structures of Toll-like receptors 3, 7, and 8 were determined.
expression of TLR3, TLR7 and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains
Porcine TLR7 and TLR8 genes from pig lymph node tissue, were cloned and characterized.
A total of 22 polymorphic sites were observed in TLR7 gene of 24 goats representing 12 different breeds, out of which 19 were present within the coding region and three in 3'UTR.
Activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
toll-like receptor 7-like
, toll like receptor 7
, toll-like receptor 7-long