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Human TLR9 Protein expressed in Wheat germ - ABIN1330558
Julian, Shao, Vangundy, Papenfuss, Crouser: Mitochondrial transcription factor A, an endogenous danger signal, promotes TNF? release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. in PLoS ONE 2013
Meta-analysis did not show any association between TLR9 polymorphisms (rs187084, rs352140, rs5743836 and rs352139) and systemic lupus erythematosus under any model.[meta-analysis]
TLR9 contributes to tumor regression by inducing cytotoxic T cell response, reducing the numbers of myeloid-derived suppressor cells, the tumor-associated macrophages, and the regulatory T cells. It can however, also promote tumor progression and invasiveness of cervical tissue. Review.
this study shows that increased expression of TLR9 is associated with reduced DNA methylation (show HELLS Proteins) in spontaneous preterm labor
A rapid neutralization of anticoagulant activity of NU172 was also demonstrated in fresh human whole blood 5 min after addition of AD. Furthermore, the TLR9-mediated activation of PMDC05 cells was interrupted after the addition of the R10-60 AD
BAD-LAMP (LAMP5)-silencing enhances TLR9 retention in endolysosome compartment and consequent downstream signalling events.
results suggest that TLR9 rs5743836 polymorphism is an independent risk factor for venous thromboembolism recurrence in female patients but not in males.
Based on the results, we hypothesize that aberrant surface expression of TLR9 on tumor cells may promote tumor growth and invasion. It might also highlight a dual contradictory role for CpG-ODNs, as adjutant in cancer therapy.
The minor alleles of TLR2-rs3775290, TLR4 (show TLR4 Proteins)-rs7873784, and TLR9-rs352140, and interaction between rs352140 and HPV infection were all associated with increased cervical cancer risk.
TLR9 polymorphism is associated with Toxoplasma gondii infection.
analysis of TLR2 rs5743708, TLR2 rs4696480, TLR4 (show TLR4 Proteins) rs4986790, TLR9 rs5743836 and TLR9 rs352140 SNPs in children with pneumococcal and meningococcal meningitis and their family members; study did not show an association between the analyzed SNPs in TLR2, TLR4 (show TLR4 Proteins), and TLR9 and susceptibility to develop bacterial meningitis
The findings support a salutary role of TLR9 in some subsets of HF conditions and underline the importance for future studies on the mechanisms of TLR9 in diastolic HF.
TLR9-driven inflammation induced a Ccr2-independent expansion of functionally enhanced extramedullary myeloid progenitors that correlated with the peripheral accumulation of monocytes in both wild-type and Ccr2(-/-) mice.
TLR9 expression on B1a cells is not critical for their IgM-dependent atheroprotection.
This study establishes a correlation between TLR-3 (show TLR3 Proteins) and TLR-9 expression with the development of EAE. In addition, evidence of a role for the myelin peptide in targeting the innate inflammatory response to the CNS is presented.
these data demonstrate that TLR7 (show TLR7 Proteins)/TLR9 ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state.
TLR9/MyD88 (show MYD88 Proteins) signaling selectively in CD11c (show ITGAX Proteins)(+) dendritic cells (DCs) strongly enhances murine cytomegalovirus clearance.
High-glucose induces tau hyperphosphorylation through activation of TLR9-P38 MAPK (show MAPK14 Proteins) pathway.
proposed that TLR9 regulates the NF-kappaB (show NFKB1 Proteins)-NLRP3 (show NLRP3 Proteins)-IL-1beta (show IL1B Proteins) pathway negatively in Salmonella-induced NKG2D (show KLRK1 Proteins)-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity.
mechanism integrating BCR, TLR9, and cytokine signals provides a peripheral checkpoint for DNA-containing antigens that, if circumvented by survival and differentiative cues, yields B cells with the autoimmune-associated T-bet+ phenotype.
we demonstrated for the first time that the cross-talk of TLR2 and TLR9 triggered Th1 (show HAND1 Proteins) activation collaboratively
Porcine parvovirus virus infection significantly induced IL-6 (show IL6 Proteins) expression and this induction depended on NF-kappaB (show NFKB1 Proteins) activation and TLR9 signaling pathways in PK-15 cell.
TLR9 immunoreactivity is mainly detected in epithelial cells and antigen presenting cells, namely dendritic and macrophage-like cells, within the range of tissues examined. The pattern of TLR9 expression was similar in pigs of 3 weeks and 3 months of age.
These data demonstrated that TLR2, TLR3 (show TLR3 Proteins) and TLR9 contribute to NF-kappaB (show NFKB1 Proteins) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Proteins).
expression of TLR3 (show TLR3 Proteins), TLR7 (show TLR7 Proteins) and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains
we studied TLR9 expression in lung extracts from pigs, dogs, and cattle.
Moreover, the TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling.
variants in the TLR1 (show TLR1 Proteins) gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
mRNA abundances of TLR9, TLR2, and TLR4 (show TLR4 Proteins) together with those of beta-defensin 5 (BNBD5 (show DEFB105A Proteins)), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands
substantial conservation of TLR9 structure and TLR9 function in blood leukocytes
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Toll-like receptor 9 protein