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results suggest a new mechanism in which Rab5 (show RAB5A Proteins) induces a change in flexibility of EEA1, generating an entropic collapse force that pulls the captured vesicle towards the target membrane to initiate docking and membrane fusion
EEA1 mobility on endosomes is decreased upon stimulation of EGF receptor (show EGFR Proteins) endocytosis in HeLa cells
Under the regulation of Rab5 (show RAB5A Proteins), the fused vesicles are targeted to early endosomes and thus deliver the internalized TbetaRI (show TGFBR1 Proteins) to the caveolin-1 (show CAV1 Proteins) and EEA1 double-positive early endosomes (caveolin-1 (show CAV1 Proteins)-positive early endosomes).
In serum-deprivated HeLa cells with low endocytic activity there two types of EEA1-vesicles: the first one carries the both EEA1 and Rab5 (show RAB5A Proteins) at high levels; the second consists of weakly decorated EEA1-vesicles that can be both Rab5 (show RAB5A Proteins)-positive and -negative.
Data indicate that early endosome antigen 1 (EEA1) is important for the small GTPase (show RACGAP1 Proteins) Rab31 (show RAB31 Proteins)-mediated enhancement of ligand-bound EGF receptor (EGFR (show EGFR Proteins)) endocytic trafficking.
nuclear uptake of Abeta (show APP Proteins) involves the dynamin (show DNM1 Proteins)-dependent EEA1 and TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling pathways.
We therefore propose that the N1072K variant of the EEA1 gene is a candidate mutation for susceptibility to diabetes in the Japanese population.
EEA1 interacts with Phafin2 and colocolizes with Phafin2 in endosome membrane.
NMR analyses of the interaction between the FYVE domain of early endosome antigen 1 (EEA1) and phosphoinositide embedded in a lipid bilayer.
p97 (show EIF4G2 Proteins) inhibition causes increased EEA1 self-association at the endosome membrane.
In the present study, decreased expression of EEA1 as well as the rearrangement of the actin was observed when Paracoccidioides brasiliensis was internalized in macrophages.
Tec (show NR4A3 Proteins) vesicles have a membrane proximal location and overlap with the tyrosine kinase (show TYRO3 Proteins) Lck (show LCK Proteins), the Tec (show NR4A3 Proteins) substrate PLC-gamma1 (show PLCG1 Proteins), and the early endosomal antigen 1 marker EEA1
phosphomimetic mutation of Thr (show TRH Proteins)-1392 in EEA1 can bypass the requirement for p38alpha (show MAPK14 Proteins) in mu opioid receptor (show OPRM1 Proteins) endocytosis
F. tularensis-containing endosomes associated with early endosome antigen 1 (EEA1) followed by lysosome-associated membrane protein 1 (LAMP-1 (show LAMP1 Proteins)), with peak coassociation frequencies occurring at 30 and 120 min postinoculation, respectively.
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
early endosome antigen 1, 162kD
, early endosome-associated protein
, endosome-associated protein p162
, zinc finger FYVE domain-containing protein 2