NFKB2 Proteins

11 Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) Proteins from 4 manufacturers are available on www.antibodies-online.com.

Data Quality
  • 9
Type
  • 11
    Protein
Antigen
  • 11
Reactivity
  • 7
  • 3
  • 1
Application
  • 9
  • 7
  • 7
  • 4
  • 3
Host
  • 4
  • 3
  • 2
  • 2
Binding Specificity
  • 2
  • 1
  • 1
  • 1
  • 1
Conjugate
  • 4
  • 2
  • 2
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  • 1
Protein Type
  • 9
Format
  • 8
11 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3094117
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3137474
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3094116
$13,376.85
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 70 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3137475
$13,376.85
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 70 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 95 %
ReactivityHuman
Application IP, SDS, ELISA, WB
Order details Cat. No. ABIN1080399
$560.00
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 95 %
ReactivityMouse (Murine)
Application IP, SDS, ELISA, WB
Order details Cat. No. ABIN1080400
$608.00
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity ≥ 98 %
ReactivityChicken
Application ELISA, IP, SDS, WB
Order details Cat. No. ABIN4988897
$704.00
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2727225
$888.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2727696
$932.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
ReactivityHuman
Application WB
Order details Cat. No. ABIN6700320
$289.00
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 1 to 2 Business Days
ReactivityHuman
Application WB
Order details Cat. No. ABIN6700319
$562.00
50 μg
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 1 to 2 Business Days
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NFKB2 Protein Profile

Protein Summary

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14- activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form\; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65 (By similarity).

Alternative names and synonyms associated with NFKB2

  • nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 (Nfkb2) antibody
  • lyt antibody
  • NF-kappaB2 antibody
  • p49 antibody
  • p49/p100 antibody
  • p50B antibody
  • p52 antibody

Protein level used designations for NFKB2

DNA-binding factor KBF2 , NF kappaB2 , nuclear factor NF-kappa-B p100 subunit , nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100

GENE ID SPECIES
18034 Mus musculus