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Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling.
autophagy causes PELI3 degradation during TLR4 (show TLR4 Proteins)-signaling, thereby impairing the hyperinflammatory phase during sepsis by inhibiting proinflammatory IL1B (show IL1B Proteins) expression
Pellino3 targets RIP1 (show RALBP1 Proteins) and regulates the pro-apoptotic effects of TNF-alpha (show TNF Proteins).
Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation.
Pellino3 targets the IRF7 (show IRF7 Proteins) pathway and facilitates autoregulation of TLR3 (show TLR3 Proteins)- and viral-induced expression of type I interferons.
Two protective, low-frequency, non-synonymous variants were significantly associated with a decrease in age-related macular degeneration (AMD (show AMD1 Proteins))risk: A307V in PELI3 and N1050Y in CFH (show CFH Proteins) .We also identified a strong protective signal for a common variant (rs8056814) near CTRB1 associated with a decrease in AMD (show AMD1 Proteins) risk (logistic regression: OR = 0.71, P = 1.8 x 10-07).
The combination of low Pellino3 levels together with high and inducible Pellino1 expression may be an important determinant of the degree of inflammation triggered upon Toll-like receptor 2 engagement by Helicobacter pylori and/or its components, contributing to Helicobacter pylori-associated pathogenesis by directing the incoming signal toward an NF-kB-mediated proinflammatory response.
Peptide PEL3 derived from the interleukin-1 receptor-associated kinase (IRAK)1 (show IRAK1 Proteins)-binding motif reveals a distinct phosphothreonine peptide binding preference.
Pellino3 is a novel upstream regulator of p38 MAPK (show MAPK14 Proteins) that activates CREB (show CREB1 Proteins) in a p38 (show CRK Proteins)-dependent manner
suggest that Pellino 3b acts as a negative regulator for IL-1 (show IL1A Proteins) signaling by regulating IRAK (show IRAK1 Proteins) degradation through its ubiquitin protein ligase (show UBE2K Proteins) activity [Pellino 3b]
The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.
E3 ubiquitin-protein ligase pellino homolog 3
, protein pellino homolog 3
, pellino homolog 3
, pellino 3