Browse our Metallothionein 1X Proteins (MT1X)

Human Metallothionein 1X (MT1X) interaction partners

1. we featured the expression patterns of MT1s in tissue obtained from various points along the spectrum of hepatocarcinogenesis. Most MT1 members were down-regulated, and MT1X were associated with HCC prognosis. Additionally, MT1X was shown to play a suppressive role in HCC metastasis.

2. Data show that in the MCF-7 breast cancer cell line, only MT1X metallothioneins (MTs) positively correlated with vascular endothelial growth factor C (VEGFC).

3. MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker showing Microsatellite Instability is associated with Persian Lynch Syndrome

4. These findings suggest that functional interactions between FHL3 and MT-1X may provide some clues to the mechanisms of FHL3-regulated cell proliferation.

5. Results show variation in MTX1 is implicated in disordered gambling

6. siRNA-mediated knockdown of TCRP1 and MT1X was found to sensitize cells to cisplatin, leading to increased apoptosis and inhibition of cell proliferation

7. Our results suggest that MT1XT20 represents a sensitive and specific marker for MSI testing and could be included in a complete set of MSI markers for the confident identification of familial or sporadic dMMR patients in colorectal cancers.

8. MT-1A, -1F, -1G, -1X and -2A isoforms are significantly down-regulated in proliferating keloid fibroblasts.

9. Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia.

10. It plays a role in the detoxification of heavy metals and reactive oxygen species. (review)