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these results demonstrate that MT2 plays a role in CD4 (show CD4 Proteins)+ T cell activation by transducing reactive oxygen species signals into an increased [Zn2+]i that subsequently affects downstream effector function
Cardioprotective effects of MT1 (show MT1 Proteins)/2 seem to be exerted via modulation of contractile elements, antioxidative enzymes, inflammatory response, and myocardial remodeling.
Metallothioneins may have a protective role against post-burn inflammation and inflammatory organ damage, at least partly through inhibiting the p38 MAPK (show MAPK14 Proteins) signaling.
Enhanced senescence due to absence of metallothionein (show MT Proteins) genes may shorten lifespan.
The MT2 receptor activates Akt (show AKT1 Proteins)/GSK-3beta/CRMP-2 (show DPYSL2 Proteins) signaling and is necessary and sufficient to mediate functional axonogenesis and synaptic formation in central neurons.
MT1 (show MT1 Proteins)/2 deficiency aggravated depleted uruanium-induced nephrotoxicity, and the molecular mechanisms appeared to be related to the increased oxidative stress and apoptosis, and decreased SGLT expression.
Zinc-binding MT1 (show MT1 Proteins) and MT2 are key modulators of Fc epsilonRI-induced basophil production of IL-4 (show IL4 Proteins).
Metallothionein (show MT Proteins) blocks oxidative DNA damage induced by acute inorganic arsenic exposure
the metal binding abilities of mouse MT2 (mMT2) with divalent (Zn(II) and Cd(II)) and monovalent (Cu(I)) ions were analyzed and compared to those of the mouse MT1 (show MT1 Proteins) (mMT1) isoform.
The results of this study suggest that metallothioneins may play a key role in protecting the kidney against high glucose-induced ROS (show ROS1 Proteins) and subsequent inflammation in diabetic nephropathy.
Report expression of similar to metallothionein-B(smt-B) upon cadmium exposure and cold shock in zebrafish (Danio rerio).
mt2 and smtb may play an important role in neurogenesis and neuroprotection.
data not only reveal a non-canonical function of Mt2 in angiogenesis, but also propose Mt2 as a novel regulator of vegfc (show VEGFC Proteins) expression.
Expression of MT-1a (show MT1A Proteins), MT-2b and MT-3 (show MT3 Proteins) were significantly higher in high zinc fed pigs.
There are evidence for implicating MT2A polymorphisms in the development of Sinonasal Inverted Papilloma. The findings also illustrate the key role played by the MT2A gene in inducing an aggressive Schneiderian Papilloma phenotype.
MT2A A-5G polymorphism may be associated with risk of developing chronic kidney disease and diabetes.
Data suggest that genotype AA for SNP rs28366003 in MT2A is associated with higher blood zinc levels in subjects with diabetes type 2 (with chronic kidney disease) as compared to control subjects. This case-control, genetic association study was conducted in the Czech Republic.
We found a significant association of SNP rs28366003 at MT2A gene with susceptibility to the dry form of AMD (show AMD1 Proteins) in a Northern Spanish population.
Our results indicated that the rs10636 and rs28366003 polymorphisms in MT2A increased breast cancer risk in Northwest Chinese Han population.
the association of the blood lead level and HDL (show HSD11B1 Proteins)-C may be modified by the MT2A genetic combination
The facility of forming bead-like structures at physiological pH for Zn5-MT2a means that Zn7-MT2a can donate up to two Zn(II) to Zn-dependent enzymes.
MT2A may be a chemosensitivity indicator in gastric cancer patients receiving docetaxel-based treatment.
Underexpression of MT2A is associated with HPV-positive head and neck cancers.
The present study was undertaken to explore further the interrelationship between p53 (show TP53 Proteins) and metallothioneins.
Metallothioneins have a high content of cysteine residues that bind various heavy metals\; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
, Metallothionein 2
, metallothionein 2
, metallothionein IIA
, metallothionein IIB
, metallothionein 2A
, metallothionein 2 A
, metallothionein II