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The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity.
ZIP5 is directed to the same subcellular locations as PrP(C (show PRNP Proteins)) and both proteins are seen to be endocytosed through vesicles decorated with the Rab5 (show RAB5A Proteins) marker protein.
miR (show MLXIP Proteins)-328 and miR (show MLXIP Proteins)-193a are expressed in tissues known to regulate Zip5 mRNA translation in response to zinc availability and both are polysome-associated consistent with Zip5 mRNA localization
Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells
ZIP4 (show SLC39A4 Proteins) and ZIP5 have roles in the adaptive response to dietary zinc in mice [ZIP5]
temporal and spatial patterns of expression of the mouse ZIP1, 3, 4, and 5 genes in the developing intestine and the effects of maternal dietary zinc deficiency on these patterns of expression were examined
Zip5 mRNA abundance does not change in response to zinc, but the translation of this mRNA was found to be zinc-responsive
we found that downregulation of ZIP5 by RNA interference inhibited esophageal cancer growth in vivo, reduced the expression of COX2, and promoted the expression of E-cadherin (show CDH1 Proteins).
ZIP5 knockdown inhibited the proliferation, migration and invasion of ESCC and suppressed COX2, cyclin D1 (show CCND1 Proteins) and E-cadherin (show CDH1 Proteins) expression, which led to the inhibition of cell progression in esophageal squamous cell carcinoma .
mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2.
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A5 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003
zinc transporter ZIP5
, solute carrier family 39 member 5
, zrt- and Irt-like protein 5
, solute carrier family 39 (metal ion transporter), member 5