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TSAP6 deficiency results in abnormal erythroid maturation and leads to microcytic anemia.
Steap3 deficiency causes abnormal iron status and homeostasis, which leads to impaired TLR4 (show TLR4 Proteins)-mediated inflammatory responses in macrophages.
Data show that the STEAP3/TSAP6 is absent in the mouse embryo fibroblasts derived from the STEAP3/TSAP6 knock-out mice (MEFs KO), but present in the wild type MEFs.
TSAP6 may augment Myt1 (show MYT1 Proteins) activity and act downstream to p53 (show TP53 Proteins) to interface apoptosis and cell-cycle progression
The DNA damage-induced p53 (show TP53 Proteins)-dependent nonclassical exosomal secretory pathway is abrogated in TSAP6-null cells.
hypochromic microcytic anemia results from a Y228H substitution in the ferrireductase Steap3 (Steap3(Y288H))
In hepatocellular carcinoma (HCC (show FAM126A Proteins)), lower expression of the STEAP3 copper reductase and heavy Cu isotope enrichment have been reported for the tumor mass, relative to the surrounding tissue
TSAP6 over expression is associated with poor survival in metastatic high-grade serous carcinoma.
heterozygous STEAP3 mutations are relatively common in humans and that their deleterious effect in humans remains to be confirmed
TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.
findings indicate that STEAP3 maintains iron storage in human malignant cells and tumor proliferation under the hypoferric condition
role for TSAP6 in the export of TCTP (show TPT1 Proteins) and indicate that this multipass membrane protein could have a general role in the regulation of vesicular trafficking and secretion.
The crystal structure of the human Steap3 oxidoreductase domain in the absence and presence of NADPH was determined.
Down-regulated expression of the TSAP6 protein in liver is associated with a transition from cirrhosis to hepatocellular carcinoma
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
STEAP family member 3
, dudulin 2
, metalloreductase STEAP3-like
, metalloreductase STEAP3
, protein nm1054
, six-transmembrane epithelial antigen of prostate 3
, tumor suppressor-activated pathway protein 6
, dudlin 2
, six transmembrane prostate protein 3
, tumor suppressor pHyde