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Syx5 plays an essential role in copper homeostasis through Ctr1A and is a candidate gene for copper-related disease in humans
dSyx5 is required for the proper function of the Golgi apparatus and that an efficiently functioning Golgi apparatus is required for the steps leading to the completion of cytokinesis and formation of mature sperm.
Expression of the Syn5 K270R mutant in cells impairs post-mitotic Golgi reassembly
Together, these data strongly suggest that syntaxin 5-mediated retrograde transport to the Golgi apparatus is a broadly conserved feature of adeno-associated virus trafficking.
Stx5 might play a role in modulating VLDL-R physiology by participating in an abrasively described or completely novel Golgi-bypass pathway.
serum anti-STX5 autoantibody, which was discovered by a proteomic approach, is a potential new serum marker for the diagnosis of endometriosis.
Depletion of syntaxin-5 complex components results in the accumulation of autophagosomes as a result of lysosomal dysfunction, leading to decreased degradation of autophagic substrates.
Syx5 is required for the maintenance of the Golgi structures but may not play a major role in the transport of vesicles carrying proteins between the ER and the Golgi compartment.
hypothesize that syntaxin 5 also has trafficking-independent functions
depletion of GM130 by RNA interference slows the rate of ER to Golgi trafficking in vivo; interactions of GM130 with syntaxin 5 and Rab1 are regulated by mitotic phosphorylation
Study shows that the SM protein, Sly1, interacts directly with the conserved oligomeric Golgi (COG) tethering complex; Sly1-COG interaction is mediated by the Cog4 subunit, which also interacts with Syntaxin 5 through a different binding site.
Stx5 is an autophagy target that is inefficiently membrane-targeted by alternative pathways; mice without WRB have different biogenesis requirements for tail anchored proteins
Pkd2 in the ER plays a role in cellular Ca(2+) homeostasis and Stx5 functions to inactivate Pkd2 and prevent leaking of Ca(2+) from ER stores
This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, syntaxin 5
, syntaxin 5A
, syntaxin 5a