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anti-Human GATAD2A Antibodies:
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Human Polyclonal GATAD2A Primary Antibody for WB - ABIN1881364
Brackertz, Gong, Leers, Renkawitz: p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. in Nucleic acids research 2006
Show all 4 Pubmed References
Human Polyclonal GATAD2A Primary Antibody for ICC, IF - ABIN4343173
Nishibuchi, Shibata, Hayakawa, Hayakawa, Ohtani, Sinmyozu, Tagami, Nakayama: Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. in The Journal of biological chemistry 2014
The MYND domain of ZMYND8 (show ZMYND8 Antibodies) directly interacts with PPPLPhi motifs in the NuRD subunit GATAD2A.
Results showed that suppression of GATAD2A attenuated thyroid cancer cell proliferation and colony formation and promoted apoptosis suggesting it as an essential factor in thyroid cancer cell pathogenesis.
These factors lead to a binding affinity hierarchy of p66alpha for the different MBD2 (show DPEP2 Antibodies) homologues (MBD2 (show DPEP2 Antibodies) approximately MBD3 (show MBD3 Antibodies) > MBD3L1 (show MBD3L1 Antibodies) approximately MBD3L2 (show MBD3L2 Antibodies)).
our data demonstrate that p66a may physically interact with STAT3 (show STAT3 Antibodies) to suppress its activity through posttranslational modification, which reveals a novel regulatory mechanism controlling STAT3 (show STAT3 Antibodies) activation during myeloid cell differentiation.
GATA zinc finger domain-containing protein 2A
, p66 alpha
, transcriptional repressor p66-alpha
, GATA zinc finger domain containing 2A
, transcriptional repressor p66 alpha
, Mi-2 histone deacetylase complex protein 66
, transcriptional repressor p66-alpha-like