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The MYND domain of ZMYND8 directly interacts with PPPLPhi motifs in the NuRD subunit GATAD2A.
Results showed that suppression of GATAD2A attenuated thyroid cancer cell proliferation and colony formation and promoted apoptosis suggesting it as an essential factor in thyroid cancer cell pathogenesis.
These factors lead to a binding affinity hierarchy of p66alpha for the different MBD2 (show DPEP2 Proteins) homologues (MBD2 (show DPEP2 Proteins) approximately MBD3 (show MBD3 Proteins) > MBD3L1 (show MBD3L1 Proteins) approximately MBD3L2 (show MBD3L2 Proteins)).
our data demonstrate that p66a may physically interact with STAT3 (show STAT3 Proteins) to suppress its activity through posttranslational modification, which reveals a novel regulatory mechanism controlling STAT3 (show STAT3 Proteins) activation during myeloid cell differentiation.
GATA zinc finger domain-containing protein 2A
, p66 alpha
, transcriptional repressor p66-alpha
, GATA zinc finger domain containing 2A
, transcriptional repressor p66 alpha
, Mi-2 histone deacetylase complex protein 66
, transcriptional repressor p66-alpha-like