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Browse our anti-Lipoic Acid Synthetase (LIAS) Antibodies

Full name:: anti-Lipoic Acid Synthetase Antibodies (LIAS)

On www.antibodies-online.com are 23 Lipoic Acid Synthetase (LIAS) Antibodies from 12 different suppliers available. Additionally we are shipping Lipoic Acid Synthetase Proteins (11) and Lipoic Acid Synthetase Kits (7) and many more products for this protein. A total of 45 Lipoic Acid Synthetase products are currently listed.

Synonyms:: 7a5ex, 2900022L22Rik, 4933425M12Rik, C77512, LAS, Lip-syn, LIP1, LS, mLip1, PDHLD, zgc:66080

list all antibodies	Gene Name	GeneID	UniProt
	LIAS	11019	O43766
	LIAS	79464	Q99M04
	LIAS	305348	Q5XIH4
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Most Popular Reactivities for anti-Lipoic Acid Synthetase (LIAS) Antibodies

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anti-Human Antibodies:

22 WB Antibodies

anti-Mouse (Murine) Antibodies:

14 WB Antibodies

anti-Rat (Rattus) Antibodies:

12 WB Antibodies

All available anti-Lipoic Acid Synthetase Antibodies

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Relevant Pathways for anti-Lipoic Acid Synthetase Antibodies

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More Antibodies against Lipoic Acid Synthetase Interaction Partners

Human Lipoic Acid Synthetase (LIAS) interaction partners

this study used a bioinformatics approach to predict its structure. . A homology model for LIAS protein was generated using X-ray crystallographic structure of Thermosynechococcus elogatsu. The active site of LIAS protein was mapped and docked with S-Adenosyl Methionine
oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS), which when mutated stabilize HIF1alpha in a non-hydroxylated form.
heterozygous mutations (c.738-2A>G and c.929T>C (p.Met310Thr)) in LIAS.
Patients with LIAS nonketotic hyperglycinemia varied in disease severity and cortical involvement.
We identified the homozygous mutation c.746G>A (p.Arg249His) in LIAS in an individual with neonatal-onset epilepsy, muscular hypotonia, lactic acidosis, and elevated glycine concentration in plasma and urine
Lipoic acid synthetase deficiency results in an overall disturbance in the antioxidant defense network, leading to increased inflammation, insulin resistance, and mitochondrial dysfunction.

Mouse (Murine) Lipoic Acid Synthetase (LIAS) interaction partners

Decreased endogenous lipoic acid gene expression plays a role in development of diabetic atherosclerosis in ApoE deficient mice.
deficiency increases oxidative stress and accelerates the development of diabetic nephropathy
Lias deficiency enhances atherosclerosis in male mice, at least in part due to reduced antioxidant capacity
Development of homozygous embryos lacking Lias is retarded.
Enhanced neutrophil sequestration in the livers of Lias+/- mice was associated with increased hepatocyte injury and increased gene expression of growth-related oncogene, E-selectin, and VCAM-1 in the liver and/or lung.

Lipoic Acid Synthetase (LIAS) Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.

Alternative names and synonyms associated with Lipoic Acid Synthetase (LIAS)

lipoyl synthase, mitochondrial (LOC5571879) antibody
lipoic acid synthetase (THAPSDRAFT_31845) antibody
lipoic acid synthetase (THAPSDRAFT_31673) antibody
lipoic acid synthetase (UREG_00501) antibody
lipoyl synthase (LOAG_04019) antibody
lipoic acid synthetase (TERG_02451) antibody
lipoic acid synthetase (Tsp_01534) antibody
lipoic acid synthetase (LIAS) antibody
lipoic acid synthetase (Lias) antibody
lipoic acid synthetase (lias) antibody
lipoic acid synthetase S homeolog (lias.S) antibody
Lipoyl synthase, mitochondrial (umc2251) antibody

7a5ex antibody
2900022L22Rik antibody
4933425M12Rik antibody
C77512 antibody
LAS antibody
Lip-syn antibody
LIP1 antibody
LS antibody
mLip1 antibody
PDHLD antibody
zgc:66080 antibody

Protein level used designations for LIAS

lipoic acid synthetase , lip-syn , lipoate synthase , lipoyl synthase, mitochondrial , LS , lipoic acid synthase , Lipoate synthase , Lipoic acid synthase , PCO124891 , PCO124891_ov , p-umc2251

GENE ID	SPECIES
5571879	Aedes aegypti
7452159	Thalassiosira pseudonana CCMP1335
7453454	Thalassiosira pseudonana CCMP1335
8437299	Uncinocarpus reesii 1704
9941423	Loa loa
10379120	Trichophyton rubrum CBS 118892
10911601	Trichinella spiralis
11019	Homo sapiens
79464	Mus musculus
305348	Rattus norvegicus
393528	Danio rerio
443960	Xenopus laevis
479108	Canis lupus familiaris
530865	Bos taurus
100279807	Zea mays

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