Browse our WT1 Proteins (WT1)

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

• Wilms tumor 1 (WT1)
• Wilms tumor 1 S homeolog (wt1.S)
• Wilms tumor 1 (wt1)
• wilms tumor 1b (wt1b)
• Wilms tumor 1 (Wt1)
• Show all gene names
• Wilms tumor protein (wt1)
• Wilms tumor 1 homolog (Wt1)
• Wilms tumor 1 L homeolog (wt1.L)

• AWT1 protein
• CWT1 protein
• D630046I19Rik protein
• EWS-WT1 protein
• gud protein
• Show all synonym aliases
• NPHS4 protein
• si:ch211-160j6.3 protein
• wagr protein
• wit-2 protein
• Wt-1 protein
• wt1 protein
• wt33 protein
• XeWT1 protein
• xwt1 protein
• XWT1a protein
• XWT1b protein
• zgc:152697 protein

Wilms tumor protein , amino-terminal domain of EWS , last three zinc fingers of the DNA-binding domain of WT1 , Chick Wilm's tumour protein , Wilms tumor 1 , Wilms tumor protein homolog A , Wilms tumor protein homolog , Wilms tumor suppressor protein 1b , Wilm's tumor suppressor , Wilms tumor protein homolog B