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Human AXIN1 Protein expressed in HEK-293 Cells - ABIN2715088
Cha, Cho, Lee, Lee, Jeong, Moon, Yun, Yang, Choi, Yoon, Kim, Kim, Kaduwal, Lee, Min, Kim, Han, Choi: Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. in Nature chemical biology 2016
analysis of differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation
APC and Axin are involved in the Wnt pathway
Axin binds directly to the export factor CRM1 in the presence of RanGTP
The Wnt/beta-catenin pathway is the most frequently deregulated pathway in hepatocellular carcinoma (HCC). Mutations of AXIN1, a member of this pathway, represent about 10% of HCC mutations. We defined a common signature of liver tumors mutated for AXIN1 and demonstrate that these tumors occur independently of the activation of the Wnt/beta-catenin pathway.
AXIN1 Gene Polymorphism is associated with Dilated Cardiomyopathy.
These were further investigated for gene expression in substantia nigra (SN) of PD and control subjects on GEO datasets. Expression differences were also assessed in normal brains SN versus white matter on BRAINEAC datasets.This finding links Parkinson's disease with inflammation.
Plasma/serum AXIN1 is an interesting biomarker to be further evaluated in endometriosis.
propose a model in which AXIN1 competes with dishevelled (DVL) for CK1 and regulates CK1-induced phosphorylation of DVL and activation of Wnt/beta-catenin signaling.
Results show that AXIN1 binds to C9orf140, a tumor-specific protein which mediates a negative feedback loop of Wnt/beta-catenin signaling.
AXIN1 and TRAIL were shown to be able to discriminate between traumatic brain injury (TBI) severity within the first hour highlighting them as new TBI biomarkers.
The expressions of AXIN and MACC1 proteins are related to the prognosis of gastric carcinoma patients, and are involved in the invasion and metastasis of gastric carcinoma.
RNF146 exerted oncogenic role through ubiquitination of Axin1 to activate beta-catenin signaling.
TRIM65 exerted oncogenic activities via ubiquitylation of Axin1 to activate the beta-catenin signaling pathway.
coexpression of APC5 and Axin genes significantly downregulated Wnt signaling in human SW480 CRC cells and inhibited cell growth.
data delineate opposing roles for gamma-Pcdh isoforms in regulating Wnt signalling and identify Axin1 as a novel protein interactor of the widely-expressed gamma-Pcdh-C3 isoform
Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma in a Chinese population.
Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT blockade by the porcupine inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT pathway inhibitor AXIN1, with consequent protein loss.
role in the formation of degradasomes and degradation of beta-catenin induced by the TNKSi G007-LK in colorectal cancer cells
VDR is important for the maintenance of physiological level of Axin1
RUNX1 and AXIN1 proteins are strongly correlated in ER(-) tumors as well.
Mutagenesis and binding studies using the bivalent TNKS binding domain of Axin1 demonstrate that only certain ankyrin repeat clusters combinations function together. SAXS analysis is consistent with a dynamic ensemble of TNKS ankyrin repeat conformations modulated by Axin1 interaction.
LGALS3 and AXIN1 genes affect tumor sizes and the mucinous component via Wnt/ beta-catenin pathway in the pathogenesis of colorectal cancer
The AXIN1 rs1805105 SNP was associated with small tumor size and early tumor stage in hepatocellular carcinoma.
Using engineered models of liver cancers with AXIN1 mutation or deletion, we defined a common signature of liver tumors mutated for AXIN1 and demonstrate that these tumors occur independently of the activation of the Wnt/beta-catenin pathway.
Overexpressed miR-128 downregulates the expression of AXIN1 but upregulates that of EAAT4 in dopamine neurons of Parkinson's disease mice.
Axin-1 is critical for spindle organization and cell cycle progression during meiotic maturation in mouse oocytes.
Axin1 promotes dendritic spine stabilization through Cdc42-dependent cytoskeletal reorganization.
Axin1 and Axin2 do not have equivalent functions in satellite cells, but are both involved in repression of Wnt/beta-catenin signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.
Study reports that NRF2 participates in the formation of a protein complex with Axin1/GSK-3/beta-TrCP that is disrupted by WNT-3A, a prototypic canonical WNT ligand, and leads to upregulation of the NRF2 transcriptional signature.
propose that disrupted Fu function in these structures underlies the head and flagellar defects in Fu-deficient sperm
Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 negatively regulates Wnt/beta-catenin signaling.
This study demonistrated that Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex in mice.
results suggestg HSV-1 replication enhancement might be mediated by the axin RGS domain.
an asymmetrical distribution pattern for Axin1 transcripts in 2-cell embryos.
Conditional disruption of Axin1 leads to development of liver tumors in mice.
The Axin/TNKS2/KIF3A complex is critical for GLUT4 translocation in response to insulin.
Phosphorylation of axin-1 by glycogen synthase kinase-3beta accelerates association of axin-1 with beta-catenin in dorsal root ganglion growth cones.
Axin1 apparently has a preventive effect on bacterial invasiveness and inflammatory response during the early stages of infection. The results suggest a distinct biological function of Axin1 and Axin2 in infectious disease and intestinal inflammation
phosphorylation of Axin and its interaction with GSK-3beta are critically required for axon formation in mouse cortex development.
Axin1 expression renders L929 cells sensitive to Aurora inhibition-induced cell death in a PARP- and AIF-dependent manner.
show that AXIN interacts with PML in vivo, and further that AXIN, PML and p53 form a ternary complex
Axin(Fu) mutation induces alternative splicing and ultimately leads to abnormal tail development in mice. There is a potential connection between alternative splicing with the expressivity and penetrance of the mutant allele.
beta-catenin1 cannot revert the ich phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS domain function.
Wnt/Axin/beta-catenin pathway has a role in ventral CNS development
Overactivation of Wnt/Axin1/beta-catenin signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of lateral plate mesoderm Nodal signaling.
A dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis, is defined.
Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing PP1 from binding Axin
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
, axin 1, isoform 1
, axis inhibition protein 1
, axis inhibitor 1
, fused, mouse, homolog of
, protein phosphatase 1, regulatory subunit 49
, protein Fused
, GSK-3beta interacting protein rAxin