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Redox-sensitive activation of p38 MAPK (show MAPK14 Proteins)/HSP27 (show HSPB1 Proteins) pathway or ERK1/2 in endothelial cells requires CaMKII
In FHC (show FTH1 Proteins)-linked TnT (show TNNI1 Proteins)-mutated hearts, RyR2 is susceptible to CaMKII-mediated phosphorylation, presumably because of a mutation-linked increase in diastolic [Ca(2 (show CA2 Proteins)+)]i, causing aberrant Ca(2 (show CA2 Proteins)+) release leading to lethal arrhythmia.
astrocytic IL-17A (show IL17A Proteins) plays important roles in the maintenance of neuropathic pain through CaMKII/CREB (show CREB1 Proteins) signaling pathway in spinal cord.
Wip1 (show PPM1D Proteins) phosphatase plays a vital role in regulating hippocampal synaptic plasticity by modulating the phosphorylation of CaMKII.
CaMKIIgamma-deficient macrophages and atherosclerotic lesions lacking myeloid CaMKIIgamma had increased expression of the transcription factor ATF6 (show ATF6 Proteins).
Destabilization of PGC1a is attributable to decreased p38 MAPK (show MAPK14 Proteins) activation via diminished CaMKII signaling. Thus, we elucidate a pathway downstream of Ca(2 (show CA2 Proteins)+)-mediated CaMKII activation that is dysfunctional in C3KO(Capn3 (show CAPN3 Proteins) knock-out mice ) mice, leading to reduced transcription of genes involved in muscle adaptation
A new molecular mechanism mediated by CAMK2gamma in intestinal epithelial cells during colitis-associated cancer (CAC (show SLC25A20 Proteins)) development, thereby providing a potential new therapeutic target for CAC (show SLC25A20 Proteins).
In young mice, 30% of adult CaMKIIalpha expression is sufficient for normal long-term potentiation in the hippocampus and cerebral cortex.
Findings demonstrate that Thr286 phosphorylation of CaMKII plays an important role in induction of long-term potentiation (LTP (show SCP2 Proteins)) by integrating Ca(2 (show CA2 Proteins)+) signals, and it greatly promotes, but is dispensable for, the activation of CaMKII and LTP (show SCP2 Proteins).
The present study demonstrates, for the first time, that ROS (show ROS1 Proteins)-dependent activation of CaMKII mediates altered Ca2 (show CA2 Proteins)+ handling and contractile dysfunction observed in the setting of sepsis.
Thus, taken into consideration the mechanism that controls the upregulation of maturation genes involved in synaptic formation, these results indicate that Etv1 (show ETV1 Proteins) orchestrates the activity-dependent regulation of both maturation and immaturation genes in developing granule cells and plays a key role in specifying the identity of mature granule cells in the cerebellum.
Laminin is instructive and CaMKII is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture.
A new molecular mechanism mediated by CAMK2gamma in intestinal epithelial cells during colitis-associated cancer (CAC (show CA2 Proteins)) development, thereby providing a potential new therapeutic target for CAC (show CA2 Proteins).
oxidative stress activated the TRPM2 (show CLU Proteins)-CaMKII cascade to further induce intracellular ROS (show ROS1 Proteins) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential
CKIalpha (show CSNK1A1 Proteins)-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII gamma and delta may have negative roles in the HCV life cycle.
Demonstrate that calcium/CaMKIIgamma/AKT (show AKT1 Proteins) signaling can regulate apoptosis and autophagy simultaneously in colorectal cancer cells.
Dysfunction in CaMKII-based signaling has been linked with a host of cardiovascular phenotypes including heart failure and arrhythmia, and CaMKII levels are elevated in human and animal disease models of heart disease.
Inhibition of CaMKII activity results in an upregulation of CaMKIV (show CAMK4 Proteins) mRNA and protein in leukemia cell lines.
CAMKIIgamma, HSP70 (show HSP70 Proteins) and HSP90 (show HSP90 Proteins) transcripts are differentially expressed in chronic myeloid leukemia (show BCL11A Proteins) cells from patients with resistant mutated disease.
CaMKII-dependent microtube polymerization may be responsible for the enhanced uptake of PEI/ON complexes in A549 cells under oxidative stress conditions.
Our data suggest that berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
, calcium/calmodulin-dependent protein kinase type II subunit gamma
, calcium/calmodulin-dependent protein kinase II beta
, calcium/calmodulin-dependent protein kinase II gamma
, CaMK II
, caM kinase II subunit alpha
, caMK-II subunit alpha
, calcium/calmodulin-dependent protein kinase type II subunit alpha
, caMK-II subunit gamma
, Ca2+/calmodulin-dependent protein kinase II
, caM kinase II subunit gamma
, caM-kinase II gamma chain
, calcium/calmodulin-dependent protein kinase type II gamma chain