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We demonstrated that the AR-miR-1 (show FSD1 Antibodies) axis negatively regulates the novel oncogenic factor, TCF7. Dysregulation of TCF7 promoted a survival advantage and resistance to androgen deprivation, suggesting its therapeutic potential for castration-resistant prostate cancer.
High expression of TCF7 is associated with osteosarcoma.
Findings indicate that breast cancer cells with a hyperactive AF1q (show MLLT11 Antibodies)/TCF7/CD44 (show CD44 Antibodies) regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
TCF7 plays critical roles in lung diseases [review]
Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective respo (show GIP Antibodies)nsiveness to GIP and enhances the magnitude of apoptotic injury.
Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin (show CTNNB1 Antibodies) signaling due to the dissociation of beta-catenin (show CTNNB1 Antibodies)/TCF-1 (show HNF1A Antibodies) complex and the process was orchestrated by STAT-3 (show STAT3 Antibodies).
we show that TCF7 is a direct target of miR (show MLXIP Antibodies)-34a in prostate cancer that has metastasized to the bone
induction of expression activates the Wnt (show WNT2 Antibodies) signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation
RUNX2 (show RUNX2 Antibodies) signaling pathways with their partners TCF7 and FGFR1 (show FGFR1 Antibodies)/2 may not be involved in CCD (show RUNX2 Antibodies) pathogenesis
Results suggest ivermectin as therapeutic WNT protein-TCF (show HNF4A Antibodies) transcription factor pathway response blocker to treat WNT (show WNT2 Antibodies)-TCF (show HNF4A Antibodies)-dependent diseases including multiple cancers.
Naive CD8 (show CD8A Antibodies)+ T Cell TCF7 expression is FOXO1 (show FOXO1 Antibodies) independent.
the inhibition of beta-catenin's TCF (show HNF4A Antibodies)-dependent transcriptional activity, independent of its protein expression level, retains the naive ground state pluripotency in mouse embryonic stem cells.
This is attributed in part to ineffective repression of Tcf1 (show HNF1A Antibodies) expression in knockout T cells, as DNMT3a (show DNMT3A Antibodies) localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8 (show CD8A Antibodies)(+) T cells. These data identify DNMT3a (show DNMT3A Antibodies) as a crucial regulator of CD8 (show CD8A Antibodies)(+) early effector cell differentiation and effector versus memory fate decisions.
The balance between CD4 (show CD4 Antibodies)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 (show BCL6 Antibodies) and Tcf7 (encoding TCF-1 (show HNF1A Antibodies)) and by the expression of the inhibitory receptors PD-1 (show PDCD1 Antibodies) and LAG3 (show LAG3 Antibodies).
data reveal that T cell factor 1 (Tcf1) long and short isoforms have distinct, yet complementary, functions and may represent an evolutionarily conserved means to ensure proper programming of CD8 (show CD8A Antibodies)(+) and CD4 (show CD4 Antibodies)(+) T cell responses to viral infection
Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP (show GIP Antibodies) and enhances the magnitude of apoptotic injury.
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
The data suggest that miR (show MLXIP Antibodies)-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 (show HNF1A Antibodies) expression in osteoblastic cells.
this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage
Our results support a critical role for miR (show MLXIP Antibodies)-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis.
The results indicate that in post-gastrula stage Xenopus embryos, the E-tail of Tcf1 (show HNF1A Antibodies) is required for expression of Lef1 (show LEF1 Antibodies) and for blood vessel formation.
results indicate that tcf1 (show HNF1A Antibodies) acts as an essential activator of foxd3 (show FOXD3 Antibodies), which is critical for dorsal mesoderm formation in early embryos
Data indicte that Tcf-1 (show HNF1A Antibodies) and Lef-1 (show LEF1 Antibodies) exhibit a function in the axis induction assay, which is lacking in Tcf-3 (show TCF3 Antibodies) and Tcf--4 (show TCF4 Antibodies).
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
T-cell-specific transcription factor 1
, transcription factor 7
, T cell factor-1
, T-cell factor 1
, transcription factor 7, T-cell specific
, transcription factor 7 (T-cell specific, HMG-box)
, T-cell factor 7
, T cell-specific transcription factor 1
, transcription factor 7 (T-cell specific, HMG-box) S homeolog
, transcription factor 7 S homeolog