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Retinoic acid signaling from the somitic mesoderm leads to activation of wnt2b expression in the intermediate mesoderm.
data reveal an unexpected positive role for Wnt (show WNT2 Proteins) signalling in liver specification, and indicate a possible common theme for the localized formation of endodermal organs along the gut (show GUSB Proteins) tube
The results reveal a key role of Wnt (show WNT2 Proteins)-Lin28 (show LIN28A Proteins)-let7 miRNA signaling in regulating proliferation and neurogenic potential of Muller glial cells in the adult mammalian retina.
the present study detected abnormal upregulation in the levels of Wnt2b and Wnt7b (show WNT7B Proteins), and hypothesized that the alterations may be due to the ectopic opening of chromatin structure.
Mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length.
targeted inactivation of the TSK (show FBN1 Proteins) gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 (show FZD4 Proteins) expression in the developing peripheral eye
we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC (show BTRC Proteins) rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 x 10(-5)) and 0.61 (0.46-0.80, 3.12x10(-4)), respectively.
ACSL5 (show ACSL5 Proteins) mediates antiproliferative activities via Wnt2B palmitoylation with diminished Wnt (show WNT2 Proteins) activity. The molecular pathway is probably relevant for intestinal homeostasis, overwhelmed by other pathways in carcinogenesis.
these results indicate that the high-expression levels of Gli1 (show GLI1 Proteins) and Wnt2B might play a pivotal role during tumorigenesis of pancreatic cancer
Results showed that miR (show MLXIP Proteins)-185-3p contributs to radioresistance of nasopharyngeal carcinoma via modulation of WNT2B expression.
secretion of WNT2B and WNT9B (show WNT9B Proteins) and stabilization of beta-catenin (CTNNB1 (show CTNNB1 Proteins)) upon virus infection negatively regulate expression of representative inducible genes IFNB1 (show IFNB1 Proteins), IFIT1 (show IFIT1 Proteins) and TNF (show TNF Proteins) in a CTNNB1 (show CTNNB1 Proteins)-dependent effector mechanism
High Wnt2B overexpression is associated with ovarian cancer metastasis and drug resistance.
This is the first report on differential regulation of WNT2 (show WNT2 Proteins) and WNT2B mRNAs in human cancer cell lines.
Wnt-2b mRNA is expressed in human ovarian cancer cells
REVIEW: Anti-WNT2B monoclonal antibodies, WNT2B RNAi compounds, or small molecule WNT2B inhibitors could be developed as novel therapeutic agents for gastric cancer and esophageal cancer in the field of clinical oncology.
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternatively spliced transcript variants.
, wingless-type MMTV integration site family, member 2B
, protein Wnt-2b-like
, protein Wnt-2b
, XWNT2, Xenopus, homolog of
, wingless-type MMTV integration site family, member 13
, wingless related MMTV integration site 2b
, wingless-type MMTV integration site 2B
, protein Wnt-2b-A