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Human WNT3A Protein expressed in Wheat germ - ABIN1325361
Zhang, Han, Chen, Shi, Yang, Ren, Chen, Zhang, Pu, Kang: Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas. in Cancer letters 2013
Wnt (show WNT2 Proteins) signaling regulates airway epithelial stem cells in adult murine submucosal glands.
Lrp6 (show LRP6 Proteins) is the key mediator of Wnt3a signaling in osteoblasts and Lrp5 (show LRP5 Proteins) played a less significant role in mediating Wnt3a signaling.
These data define the mechanism responsible for the repressive effects of nitric oxide (NO) on the transcriptional activity of beta-catenin (show CTNNB1 Proteins) and link eNOS (show NOS3 Proteins)-derived NO to the modulation by VEGF (show VEGFA Proteins) of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-induced endothelial cell proliferation.
These results indicate that PEDF (show SERPINF1 Proteins) counters Wnt (show WNT2 Proteins) signaling to allow for osteoblast differentiation and provides a mechanistic insight into how the PEDF (show SERPINF1 Proteins) null state results in OI type VI.
These results suggest novel mechanisms for Wnt3a-induced osteoblast proliferation and cell survival via Npnt (show NPNT Proteins) gene expression
this study shows that the Wnt3a expression levels in dendritic cells influences the generation of memory T cells after 5 days in co-culture with naive T cells through activation of the Wnt (show WNT2 Proteins) canonical pathway
Wnt3a induces Osx (show SP7 Proteins) expression via p38 MAPK (show MAPK14 Proteins) signaling in dental follicle cells. Wnt3a-induced Osx (show SP7 Proteins) expression was inhibited in the presence of p38 mitogen-activated protein kinase (show MAPK14 Proteins) (MAPK (show MAPK1 Proteins)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.
Furthermore, pigment epithelium-derived factor (PEDF (show SERPINF1 Proteins)), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2 (show SOD2 Proteins)) and catalase (show CAT Proteins).
Ginkgo biloba exocarp extract inhibits tumor angiogenesis, which may be closely relevant to its effect in blockage of Wnt (show WNT2 Proteins) /beta-catenin (show CTNNB1 Proteins)-VEGF (show VEGFA Proteins) signaling pathway in Lewis lung carcinoma.
Western blot analysis demonstrated that following BMP2 (show BMP2 Proteins) and BMP7 (show BMP7 Proteins) cotransfection of MC3T3E1 cells, the protein expression levels of BMP2 (show BMP2 Proteins), BMP4 (show BMP4 Proteins), BMP6 (show BMP6 Proteins), BMP7 (show BMP7 Proteins), BMP9 (show GDF2 Proteins) and Wnt3a were increased compared with control cells
Suggest that GPC5 (show GPC5 Proteins) is able to suppress the lung adenocarcinoma metastasis by competitively binding to Wnt3a and inactivating the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.
WNT3A/beta-catenin signaling inhibition is involved in leflunomide-mediated cytotoxic effects on renal carcinoma cells
BRG1 (show SMARCA4 Proteins) may contribute to colon cancer progression through upregulating WNT3A expression.
Here we describe a one-step immobilization technique to covalently bind WNT3A proteins as a basal surface with easy storage and long-lasting activity. We show that this platform is able to maintain adult and embryonic stem cells while also being adaptable for 3D systems
study reveals that Foxi1 (show FOXI1 Proteins)/miR (show MLXIP Proteins)-491-5p/Wnt3a/beta-catenin (show CTNNB1 Proteins) signaling is critical in the progression of GC. Targeting the pathway described in this study may open up new prospects to restrict the progression of gastric cancer
CHIR suppressed the hypertrophic propensity of the MSC (show MSC Proteins)-derived cartilage after in vivo implantation to an extent approaching that of WNT3A protein. These results indicate that CHIR may be a promising alternative for WNT3A protein for certain applications of human bone marrow-derived MSCs.
PEGylated Wnt3A liposomes associated with skeletal stem cell populations in human bone marrow and promoted osteogenesis.
The AChE plays a role in osteoblastic differentiation and is regulated by both Wnt3a and Runx2 (show RUNX2 Proteins).
In promoting the self-renewal symmetric division of hTERT(high) prostate cancer cells, WNT3a dramatically decreased the ratio of hTERT(high) prostate cancer cells undergoing asymmetric division. Increased WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signal activation was also detected in hTERT(high) prostate cancer cells. hTERT-mediated CSC properties were at least partially dependent on beta-catenin (show CTNNB1 Proteins).
the results indicate neighboring structural elements within full-length Wnt3a affect saposin-like subdomain (SLD) conformational stability. Moreover, SLD function(s) in Wnt (show WNT2 Proteins) proteins appear to have evolved away from those commonly attributed to SAPLIP family members.
Data suggest that Wnt3, Wnt3a, and Wnt8a (show WNT8A Proteins) bind to their respective receptors (Fz8 (show FZD2 Proteins), Lrp6 (show LRP5 Proteins), and Lypd6 (show LYPD6 Proteins)) in ordered plasma membrane environments; ordered plasma membrane environments appear to be essential for binding of Wnt (show WNT2 Proteins) proteins to their receptor complexes and stimulation of downstream signaling activity.
It was shown that Wnt3a-Wnt8a (show WNT8A Proteins)/beta-catenin (show CTNNB1 Proteins) signaling directly regulates ciliogenic transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle.
In zebrafish embryos lacking Wnt3a, Wnt1 (show WNT1 Proteins) and Wnt10b (show WNT10B Proteins), the expression of engrailed orthologs, pax2a and fgf8 (show FGF8 Proteins) is not maintained after mid-somitogenesis
data suggest a specific role for Wnt3a in the development of cardiac NCCs; propose that this function of wnt3a in r6 is partially mediated by crip2 (show CRIP2 Proteins) expression in the premigratory cardiac NCCs, which subsequently affects cardiac function and PA patterning
Sulf1 (show SULF1 Proteins) does not affect Wnt3a-mediated activation of canonical Wnt (show WNT2 Proteins) signaling.
Wnt3a protein alone is sufficient to rescue the severe loss of inner ear structures resulting from dorsal but not ventral half ablations.
hindbrain-repressive Wnt3a/Meis3/Tsh1 circuit promotes neuronal differentiation and coordinates tissue maturation
Wnt3a thus acts downstream of FAK (show PTK2 Proteins) to balance anterior-posterior cell fate specification in the developing neural plate
Data suggest a new model for neural anteroposterior patterning, in which Wnt3a from the paraxial mesoderm induces posterior cell fates via direct activation of a crucial transcription factor in the overlying neural plate.
Wnt3A secretion from tectal cells along with ephrin-B1 (show EFNB1 Proteins) signaling are specifically responsible for enhanced neural responses in the developing optic tectum.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.
wingless-type MMTV integration site family, member 3A
, protein Wnt-3a-like
, protein Wnt-3a
, vestigial tail
, wingless-type MMTV integration site family, member 3 like
, wnt3 like
, wingless-type MMTV integration site family, member 3
, Wnt-3a homolog
, Wnt3a variant 3
, wingless-type MMTV integration site family member 3a
, wingless-related MMTV integration site 3A