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Caudal Wnt8a is expressed only early somite stages. It is needed for normal anterior trunk development in the absence of Wnt3a (show WNT3A Proteins). Wnt8a and Wnt3a (show WNT3A Proteins) cooperate to maintain Fgf8 (show FGF8 Proteins) expression and stop premature Sox2 (show SOX2 Proteins) up-regulation in the axial stem cell niche.
Wnt8a expression depends on the presence of Fgf3 (show FGF3 Proteins) indicating a serial regulation between Fgf and Wnt (show WNT2 Proteins) signalling during otic placode induction and specification.
demonstrate that both the enlargement of the otic placode and the expansion of the Wnt8a expression domain can be rescued in Spry1 (show SPRY1 Proteins)/; Spry2 (show SPRY2 Proteins)/ embryos by reducing the gene dosage of Fgf10 (show FGF10 Proteins)
FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.
The Wnt8A expression was evaluted in the resultant Tg(CAG-mWnt8A) embryos to identify mWnt8A misexpression.
the WNT8A gene is involved in the susceptibility to HSCR (show EDNRB Proteins), and plays an important role in the occurrence and development of Hirschsprung's disease.
Expression and regulation of WNT8A mRNA in human tumor cell lines
The results demonstrate that the argon plasma jet (show FBXL15 Proteins) has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt (show WNT2 Proteins))/beta-Catenin (show CTNNB1 Proteins)-signaling pathways.
These results indicated that maternal wnt8a is dispensable for the initial dorsal determination, but cooperates with zygotic wnt8a for ventrolateral and posterior tissue formation.
Wnt (show WNT2 Proteins) signaling balances specification of the cardiac and pharyngeal muscle fields.
Data suggest that Wnt3 (show WNT3A Proteins), Wnt3a (show WNT3A Proteins), and Wnt8a bind to their respective receptors (Fz8 (show FZD2 Proteins), Lrp6 (show LRP5 Proteins), and Lypd6 (show LYPD6 Proteins)) in ordered plasma membrane environments; ordered plasma membrane environments appear to be essential for binding of Wnt (show WNT2 Proteins) proteins to their receptor complexes and stimulation of downstream signaling activity.
Wnt8, in addition to its well-established role in posterior mesoderm patterning, also plays a later role as a factor that expands the renal progenitor pool prior to kidney morphogenesis.
Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a, grip2a, and Dazl (show DAZL Proteins), in the zebrafish embryo have been presented.
Gain of function of Wnt8a results in the accumulation of beta-catenin (show CTNNB1 Proteins) into the nuclei of all cells of the gastrula from the margin to the animal pole.
A filopodia-based transport system for Wnt8a controls anteroposterior patterning of the neural plate during vertebrate gastrulation.
Wnt (show WNT2 Proteins) limits its own signaling activity in part via up-regulation of a transporter, slc35c1 that promotes terminal fucosylation and thereby limits Wnt (show WNT2 Proteins) activity.
Dynamic association with donor cell filopodia and lipid-modification are essential features of Wnt8a during patterning of the zebrafish neuroectoderm.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. It encodes a protein which shows 81% amino acid identity to the mouse Wnt8A protein.
wingless-type MMTV integration site family, member 8A
, protein Wnt-8a
, protein Wnt-8a-like
, protein Wnt-8d
, stimulated by retinoic acid gene 11 protein
, wingless-related MMTV integration site 8D
, wingless-related MMTV integration site 8A
, protein Wnt-8a ORF1
, protein Wnt-8c