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Aggrecan Proteins (ACAN)

ACAN encodes a calcium-binding mitochondrial carrier protein. Additionally we are shipping Aggrecan Antibodies (135) and Aggrecan Kits (59) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACAN 176  
ACAN 11595 Q61282
ACAN 58968 P07897
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Top Aggrecan Proteins at

Showing 9 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Human Un-conjugated 100 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human His tag,S tag 50 μg Log in to see 9 to 11 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 14 to 16 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 11 to 13 Days

ACAN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
Rat (Rattus)

Top referenced Aggrecan Proteins

  1. Human Aggrecan Protein expressed in HEK-293 - ABIN2666766 : Doege, Sasaki, Kimura, Yamada: Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms. in The Journal of biological chemistry 1991 (PubMed)
    Show all 5 references for ABIN2666766

More Proteins for Aggrecan (ACAN) Interaction Partners

Human Aggrecan (ACAN) interaction partners

  1. Citrullinated Proteoglycan (show Vcan Proteins) Aggrecan is a new member of citrullinated proteins identified in human joints.

  2. Idiopathic short stature is due to novel heterozygous mutation of the aggrecan gene.

  3. rs2056202 and rs2292813 in SLC25A12 (show Slc25a12 Proteins) may contribute significantly to autism spectrum disorders risk.

  4. Identification of homozygous deletion in ACAN and other candidate variants in familial classical Hodgkin lymphoma by exome sequencing.

  5. ACAN positive perineuronal nets and glial cells were decreased in the amygdala of szhizophrenia and bipolar disorder patients compared to controls.

  6. An underlying interaction between aggrecan VNTR and obesity in symptomatic lumbar disc herniation.

  7. The results suggest that regions within ACAN is associated with ACL (show ACLY Proteins) injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties.

  8. results suggested that genetic variants in ACAN and MET are associated with HM. Functional roles of ACAN and MET in the development of HM need to be further investigated

  9. Data show there was no significant difference in the aggrecan (ACAN) rs1516797 genotype or allele distributions between the carpal tunnel syndrome (CTS (show TTR Proteins)) and control groups.

  10. Heterozygous mutations in ACAN can cause a mild skeletal dysplasia, which presents clinically as short stature with advanced bone age.

Cow (Bovine) Aggrecan (ACAN) interaction partners

  1. the subsequent presentation of aggregan from ECM (show MMRN1 Proteins) leads to CD4 (show CD4 Proteins)(+) T-cell activation and effector cell formation.

  2. Data show that expression of mRNAs for aggrecan, collagen type II, and versican (show Vcan Proteins) were significantly effected by the intervention.

  3. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (show ADAMTS5 Proteins) (aggrecanase (show ADAMTS4 Proteins)) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo.

  4. Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated.

  5. aggrecanase (show ADAMTS4 Proteins) activity (a) is responsible for early TNFalpha (show TNF Proteins)-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.

  6. Maintenance of structure and organization of extracellular matrix comprising chondron and pericellular microenvironment of chondrocytes in articular cartilage is important for distribution of newly synthesized aggrecan monomers within tissue.

  7. aggrecan plays a protective role in preventing degradation of collagen fibrils

  8. Changes in aggrecan and type II collagen (show COL2A1 Proteins) promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations.

  9. AGC1 mRNA expression level was upregulated by multidirectional articular motion.

  10. Homozygosity mapping in candidate regions in a small Dexter pedigree suggested aggrecan as the most likely candidate gene. Mutation screening revealed a 4-bp insertion in exon 11 (2266_2267insGGCA) and a second, rarer transition in exon 1 (-198C>T).

Mouse (Murine) Aggrecan (ACAN) interaction partners

  1. Aggrecan has a major role in regulating the expression of key growth factors and signaling molecules during development of cartilaginous tissue and is essential for proper chondrocyte organization, morphology, and survival.

  2. Aggrecan, link protein (show HAPLN1 Proteins) and TN-R (show TNR Proteins) were identified to be essential for the neuroprotective properties of the perineuronal net.

  3. the subsequent presentation of aggregan from ECM (show MMRN1 Proteins) leads to CD4 (show CD4 Proteins)(+) T-cell activation and effector cell formation.

  4. Runx3 (show RUNX3 Proteins) positively regulates aggrecan expression and suggest that its function is more limited to cartilage development than to bone.

  5. The role of ADAMTS5 (show ADAMTS5 Proteins) in tendon is to remove pericellular and interfibrillar aggrecan to maintain the molecular architecture responsible for normal tissue function.

  6. role of ADAMTS5 (show ADAMTS5 Proteins) in dermal repair through CD44 (show CD44 Proteins)-mediated aggrecan accumulation and modulation of transforming growth factor beta1 (TGFbeta1 (show TGFB1 Proteins)) signaling

  7. CSGalNAcT-1 (show CSGALNACT1 Proteins) is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan.

  8. Data show that strong aggrecan gene expression was observed in growth plate and articular cartilage as well as the fibrocartilage of meniscus, trachea, and intervertebral disc.

  9. A remote upstream element regulates tissue-specific expression of the rat aggrecan gene

  10. the aggrecan promoter has an osteogenic protein-1 (show BMP7 Proteins) responsive element

Horse (Equine) Aggrecan (ACAN) interaction partners

  1. At 0.1 and 1 microM concentrations, LE135 weakly but significantly increased chondral morphology scores, compared to untreated controls. Lack of aggrecan expression and lack of increased CII:CI ratio, compared to controls, did not affect chondrogenesis.

  2. degenerative suspensory ligament desmitis ligaments showed a 15-fold increase in aggrecan compared to normal

Pig (Porcine) Aggrecan (ACAN) interaction partners

  1. keratan sulphate in the interglobular domain of pig aggrecan has a microstructure that is distinct from keratan sulphate in the keratan sulphate-rich region

Rabbit Aggrecan (ACAN) interaction partners

  1. Aggrecan synthesis in intervertebral disc cells is stimulated by E-cadherin (show CDH1 Proteins).

Aggrecan (ACAN) Protein Profile

Protein Summary

This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene.

Gene names and symbols associated with Aggrecan Proteins (ACAN)

  • aggrecan (LOC100380783)
  • aggrecan (ACAN)
  • aggrecan (Acan)
  • aggrecan (AGC)
  • solute carrier family 25 (aspartate/glutamate carrier), member 12 (SLC25A12)
  • Agc protein
  • Agc1 protein
  • AGCAN protein
  • ARALAR protein
  • b2b183Clo protein
  • cmd protein
  • Cspg1 protein
  • CSPGCP protein
  • MSK16 protein
  • SEDK protein

Protein level used designations for Aggrecan Proteins (ACAN)

aggrecan , aggrecan core protein-like , aggrecan core protein , cartilage-specific proteoglycan core protein , chondroitin sulfate proteoglycan core protein 1 , large aggregating proteoglycan , CSPCP , aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122) , aggrecan epidermal growth factor-like domain-1 , aggrecan 1 , chondroitin sulfate proteoglycan 1 , large aggregating proteoglycan, antigen , aggrecan, structural proteoglycan of cartilage , cartilage aggregating proteoglycan , aggrecan interglobular domain , chondroitin sulfate proteoglycan core protein , araceli hiperlarga , calcium binding mitochondrial carrier superfamily member Aralar1 , calcium-binding mitochondrial carrier protein Aralar1 , mitochondrial aspartate glutamate carrier 1 , solute carrier family 25 (mitochondrial carrier, Aralar), member 12

100380783 Salmo salar
100432072 Pongo abelii
176 Homo sapiens
280985 Bos taurus
403828 Canis lupus familiaris
11595 Mus musculus
58968 Rattus norvegicus
100033876 Equus caballus
397255 Sus scrofa
100731672 Cavia porcellus
395798 Gallus gallus
100009079 Oryctolagus cuniculus
100861256 Capra hircus
443001 Ovis aries
101084542 Felis catus
8604 Homo sapiens
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