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Aggrecan Products

(Aggrecan (ACAN))

Categories

This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008].

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Featured Aggrecan Categories

Aggrecan Antibodies

High quality antibodies with extensive validation data.

Aggrecan ELISA Kits

Reliable ELISA kits for a wide range of species.

Aggrecan Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Aggrecan Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rabbit, Rat
Application ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (6)
  • (2)
Cat. No. ABIN673599
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application ICC, IHC, WB
Validations
  • (3)
Cat. No. ABIN1857939
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, ELISA, WB
Validations
  • (3)
Cat. No. ABIN559808
Quantity 100 μg
Datasheet Datasheet

Recommended Aggrecan ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (6)
  • (5)
Cat. No. ABIN6730910
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6953560
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964680
Quantity 96 tests
Datasheet Datasheet

Recommended Aggrecan Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1305598
Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1305600
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3008150
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Aggrecan products

Sun, Sun, Sun, Jiang, Lin, Kong, Li, Zhu, Huan, Zheng, Wang, Zou, Gao, Xu, Shi: "Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction." in: Oxidative medicine and cellular longevity, Vol. 2021, pp. 3225439, (2022) (PubMed).

Sun, Zhu, Sun, Sun, Huan, Zhang, Lin, Zheng, Jiang, Luo, Xu, Shi: "Neuropeptide Y prevents nucleus pulposus cells from cell apoptosis and IL‑1β‑induced extracellular matrix degradation." in: Cell cycle (Georgetown, Tex.), Vol. 20, Issue 10, pp. 960-977, (2022) (PubMed).

Song, Li, Sun, Zhao: "Fxyd5 activates the NF‑κB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation." in: Molecular medicine reports, Vol. 25, Issue 4, (2022) (PubMed).

Xuan, Hu, Geng, Song, Shen, Lei, Guan, Zhao, You: "Biofunctionalized chondrogenic shape-memory ternary scaffolds for efficient cell-free cartilage regeneration." in: Acta biomaterialia, Vol. 105, pp. 97-110, (2021) (PubMed).

Luo, Huan, Lin, Kong, Sun, Li, Zhu, Sun, Xu, Sun, Duan, Shi: "Ulinastatin Ameliorates IL-1β-Induced Cell Dysfunction in Human Nucleus Pulposus Cells via Nrf2/NF-κB Pathway." in: Oxidative medicine and cellular longevity, Vol. 2021, pp. 5558687, (2021) (PubMed).

Szeremeta, Jura-Półtorak, Zoń-Giebel, Kopeć-Mędrek, Kucharz, Olczyk: "Aggrecan Turnover in Women with Rheumatoid Arthritis Treated with TNF-α Inhibitors." in: Journal of clinical medicine, Vol. 9, Issue 5, (2020) (PubMed).

Yang, Zhu, Zhu, Feng, Gong, Chen, Chen: "17β-Estradiol/extrogen receptor β alleviates apoptosis and enhances matrix biosynthesis of nucleus pulposus cells through regulating oxidative damage under a high glucose condition." in: Biomedicine & pharmacotherapy, Vol. 107, pp. 1004-1009, (2019) (PubMed).

Chen, Liu, Li, Wu: "Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells following transfection with Indian hedgehog and sonic hedgehog using a rotary cell culture system." in: Cellular & molecular biology letters, Vol. 24, pp. 16, (2019) (PubMed).

Liu, Zhang, Zhang, Zhang, Du, Zhang, Zhang, Xu, Wu, Zhang, Li, Tan, Huang: "Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in nucleus pulposus cells." in: Bioscience reports, Vol. 39, Issue 4, (2019) (PubMed).

Jiang, Fu, Song: "Responses of apoptosis and matrix metabolism of annulus fibrosus cells to different magnitudes of mechanical tension in vitro." in: Bioscience reports, Vol. 39, Issue 2, (2019) (PubMed).

Synonyms and alternative names related to Aggrecan

aggrecan (ACAN), aggrecan (Acan), aggrecan core protein (LOC100380783), aggrecan (AGC), Agc, AGC1, Agc1, AGCAN, b2b183Clo, cmd, CSPG1, Cspg1, CSPGCP, MSK16, SEDK

Protein level used designations for Aggrecan

  • aggrecan core protein
  • cartilage-specific proteoglycan core protein
  • chondroitin sulfate proteoglycan core protein 1
  • large aggregating proteoglycan
  • CSPCP
  • aggrecan 1
  • aggrecan, structural proteoglycan of cartilage
  • aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)
  • aggrecan epidermal growth factor-like domain-1
  • chondroitin sulfate proteoglycan core protein
  • cartilage aggregating proteoglycan
  • chondroitin sulfate proteoglycan 1
  • large aggregating proteoglycan, antigen
  • aggrecan
  • aggrecan core protein-like
  • aggrecan interglobular domain
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