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Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. Additionally we are shipping Angiostatin Kits (43) and Angiostatin Proteins (10) and many more products for this protein.
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Human Polyclonal ANG Primary Antibody for WB - ABIN108506
Sim BK,O'Reilly MS,Liang H,Fortier AH,He W,Madsen JW,Lapcevich R,Nacy CA: A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer. in Cancer Res 1997
Show all 4 references for ABIN108506
Human Monoclonal ANG Primary Antibody for IP, WB - ABIN967561
Fidler: Cancer metastasis. in British medical bulletin 1991
Show all 2 references for ABIN967561
Plasminogen (show PLG Antibodies)-deficient mice frequently develop colon lesions and rectal prolapses.
manganese transport protein (show SLC11A2 Antibodies) C (show PROC Antibodies) (MntC) is an extracellular matrix- and plasminogen-binding protein (show ENO1 Antibodies)
Plg (show PLG Antibodies) from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2 (show Lp-PLA2 Antibodies)), suggesting that linkage to Plg (show PLG Antibodies) protects oxPtdPCs from metabolism during their transport in the plasma.
plg (show PLG Antibodies)-/- and tPA (show PLAT Antibodies)-/- mice exhibit brain parenchymal fibrin deposits that appear to result from reduced neurovascular integrity
plasminogen (show PLG Antibodies)-dependent proteolysis has a beneficial effect during neurological recovery after stroke.
Pla-induced mononuclear cell recruitment in vivo was dependent on protease-activated receptor-1 activation of the MEK/ERK/NF-kappaB pathway, which led to the release of CCL2 and activation of CCR2.
Plg (show PLG Antibodies) may play an important role in innate immunity by changing expression of genes that contribute to phagocytosis.
Plasminogen (show PLG Antibodies) is a key molecular determinant of inflammatory joint disease capable of simultaneously driving or ameliorating arthritis pathogenesis in distinct anatomic locations in the same subject.
Plasmin (show PLG Antibodies) suppresses brain metastasis in two ways: by converting membrane-bound astrocytic FasL (show FASL Antibodies) into a paracrine death signal for cancer cells, and by inactivating the axon pathfinding molecule L1CAM (show L1CAM Antibodies), which metastatic cells express for spreading along brain capillaries and for metastatic outgrowth.
Plasminogen (show PLG Antibodies) stimulates autocrine cytokine production in human airway smooth muscle cells in a manner mediated by plasmin (show PLG Antibodies) and annexin A2 (show ANXA2 Antibodies).
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity).
, plasmin heavy chain A
, plasmin light chain B