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Apolipoprotein E Proteins (APOE)

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Additionally we are shipping APOE Antibodies (350) and APOE Kits (139) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APOE 11816 P08226
APOE 348 P02649
APOE 25728 P02650
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Top APOE Proteins at

Showing 10 out of 50 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Mammalian Cells Mouse His tag   50 μg Log in to see 5 Days
HOST_Human Human His tag   10 μg Log in to see 11 Days
HOST_Human Human Un-conjugated 50 μg Log in to see 2 to 3 Days
HOST_Human Human Un-conjugated   100 μg Log in to see 7 to 9 Days

APOE Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , ,
Human , ,
Rat (Rattus) ,

More Proteins for Apolipoprotein E (APOE) Interaction Partners

Mouse (Murine) Apolipoprotein E (APOE) interaction partners

  1. DPP (show DSPP Proteins)-4I, MK0626, but not native incretins has protective effects against AAA (show AAAS Proteins) in Ang II (show AGT Proteins)-infused Apoe/ mice via suppression of inflammation, proteolysis, and fibrosis in the aortic wall

  2. Results suggest that the pathological effects of ApoE4 in astrocytes may be mediated by impaired autophagy and by the concomitant impaired ability of the cells to remove Abeta (show APP Proteins) plaques

  3. Treatment of an Alzheimer's disease mouse model with genistein results in a remarkable and rapid improvement in various parameters of cognition; a lowering of Abeta (show APP Proteins) levels in brain, in the number and the area of amyloid plaques (confirmed in vivo by positron emission tomography) as well as in microglial reactivity; and incubation of primary astrocytes with genistein results in a PPARgamma (show PPARG Proteins)-mediated increased release of ...

  4. Results demonstrate that iron alters ApoE protein levels in neurons and astrocytes, and also affects the secretion of ApoE fragments, show that ApoE mRNA expression is enhanced by iron in astrocytes but not in neurons

  5. Lack of neural compensatory mechanisms of BDNF (show BDNF Proteins) val66met met carriers and APOE E4 carriers in healthy aging, mild cognitive impairment, and Alzheimer's disease

  6. Macrophage IGF1R (show IGF1R Proteins) signaling suppresses macrophage and foam cell accumulation in lesions and reduces plaque vulnerability, providing a novel mechanism whereby IGF-1 (show IGF1 Proteins) exerts antiatherogenic effects in ApoE knockout mice.

  7. This study demonstrated the GFAP (show GFAP Proteins)-ApoE4 mice exhibited motor impairments when compared to GFAP (show GFAP Proteins)-ApoE3 and wild-type mice.

  8. The results of the current study indicated that vaspin (show SERPINA12 Proteins) inhibited the progression of atherosclerotic plaques in apoE(/) mice by inhibiting endoplasmic reticulum stress-induced macrophage apoptosis.

  9. Epigenetic Control of Apolipoprotein E Expression Mediates Gender-Specific Hematopoietic Regulation.

  10. These findings may be clinically relevant because HDL's APOE content associates with CVD risk and ABCA1 (show ABCA1 Proteins) deficiency promotes unregulated cholesterol accumulation in human macrophages.

Human Apolipoprotein E (APOE) interaction partners

  1. Study suggested that conventional criteria for Mild Cognitive Impairment may be susceptible to false positive diagnostic errors, and that onset of Abeta (show APP Proteins) accumulation may occur earlier in APOE varepsilon4 carriers compared to non-carriers

  2. The analysis suggested that ApoEepsilon4 mutation was associated with the increased risk of CHD (show CHDH Proteins), while ApoEepsilon2 allele had a decreased risk of CHD (show CHDH Proteins) just in Caucasians.

  3. Data revealed that ApoE e4 allele is associated with increased risk of coronary artery disease (CAD) in Kashmiri population.

  4. Review/Meta-analysis: APOE E2/E2 might be one of the factors affecting warfarin dose requirements. The effect of APOE may vary between ethnicities.

  5. The epsilon4 allele of the APOE gene was significantly associated with both early and late onset Alzheimer's distributions but with opposite effect.

  6. Haplotype analysis reveals a strong association of the interaction of DNMT3B (show DNMT3B Proteins) gene with APOEepsilon4 in a sample of Alzheimer disease patients.

  7. LDLR (show LDLR Proteins) A(+)A(+) genotype, ApoB (show APOB Proteins) X(+) allele and ApoE E4 allele increased the risk of premature coronary artery disease by 1.8, 2.1 and 12.1 respectively.

  8. Study found a significant interaction of age and ApoE genotype on task-related activation bilaterally in anterior cingulate gyrus and superior frontal gyrus, as well as left and right insula. Old age was associated with increased activity in varepsilon4 carriers. Recruitment of neuronal resources resulted in enhanced memory performance in young varepsilon4 carriers.

  9. APOE is involved with late onset Alzheimer's disease. [review]

  10. We evaluated whether APOE is a 'variability gene' for body mass index, depressive symptoms, and cognition (verbal, spatial, attention, working memory, perceptual speed) in twin studies from four countries, and whether it partly represents the 'G' in GxE effects. Results suggested that APOE may represent a 'variability gene' for depressive symptoms and spatial reasoning, but not for BMI or other cognitive measures.

Rabbit Apolipoprotein E (APOE) interaction partners

  1. we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.

  2. The molar ratio ApoE/ApoA-I (show APOA1 Proteins) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.

  3. ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity

  4. The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.

Pig (Porcine) Apolipoprotein E (APOE) interaction partners

  1. These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant

Cow (Bovine) Apolipoprotein E (APOE) interaction partners

  1. Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE, MTP (show MTTP Proteins), and LDLR (show LDLR Proteins), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.

  2. Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism

  3. apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 Proteins) particles, and lipid-free forms were included in cow plasma

  4. after calving the apolipoprotein B(100 (show APOB Proteins)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP Proteins)) and apolipoprotein E messenger RNA abundance were higher in the liver

Chimpanzee Apolipoprotein E (APOE) interaction partners

  1. The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.

  2. ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.

Rhesus Monkey Apolipoprotein E (APOE) interaction partners

  1. In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals

  2. Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world

  3. There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.

APOE Protein Profile

Protein Summary

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Gene names and symbols associated with Apolipoprotein E Proteins (APOE)

  • apolipoprotein E (apoe)
  • apolipoprotein Ea (apoea)
  • apolipoprotein E (Apoe)
  • apolipoprotein E (APOE)
  • AD2 protein
  • AI255918 protein
  • Apo-E protein
  • apoe protein
  • APOEA protein
  • apoprotein protein
  • im:7036787 protein
  • LDLCQ5 protein
  • LPG protein
  • wu:fb69a05 protein
  • zgc:110064 protein

Protein level used designations for Apolipoprotein E Proteins (APOE)

apolipoprotein E , ApoE-1 , apo-E , apolipoprotein E3

394678 Xenopus (Silurana) tropicalis
553587 Danio rerio
100136023 Oncorhynchus mykiss
100380959 Xenopus laevis
11816 Mus musculus
348 Homo sapiens
100009337 Oryctolagus cuniculus
25728 Rattus norvegicus
397576 Sus scrofa
100731633 Cavia porcellus
281004 Bos taurus
476438 Canis lupus familiaris
449586 Pan troglodytes
714623 Macaca mulatta
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