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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Additionally we are shipping APOE Antibodies (320) and APOE Kits (104) and many more products for this protein.
Showing 10 out of 41 products:
Human APOE Protein expressed in Human - ABIN934462
Krul, Cole: Quantitation of apolipoprotein E. in Methods in enzymology 1996
Systemic administration of irisin (show FNDC5 Proteins) may be protected against endothelial injury and ameliorated atherosclerosis in apoE(-/-) diabetic mice.
NPY (show NPY Proteins) might be involved in the pathogenesis of METH (show MTRR Proteins)-induced atherogenic effects through NPY (show NPY Proteins) Y1 receptor pathway in ApoE knockout mice
Plasmalogen enrichment via batyl alcohol supplementation attenuated atherosclerosis in ApoE- and ApoE/GPx1 (show GPX1 Proteins)-deficient mice.
Cx37 (show GJA4 Proteins) deletion increased the size of atherosclerotic lesions in oscillatory shear stress regions and abrogated the development of a stable plaque phenotype under OSS in ApoE(-/-) mice
When chronic allergic lung inflammation (ALI)and atherosclerosis were produced simultaneously, ALI increased atherosclerotic lesion size, inflammatory cell content, elastin (show ELN Proteins) fragmentation, smooth muscle cell loss, lesion cell proliferation, and apoptosis.
ApoE(-/-) mice receiving WD showed abnormal glucose tolerance, hepatomegaly, weight gain and full spectrum of NASH (show SAMSN1 Proteins) including hepatic steatosis, fibrosis and inflammation, with no sign of renal damage
Long-lasting exposure to ox-LDL decreases the expression of Sirt1 (show SIRT1 Proteins) and Runx2 (show RUNX2 Proteins) in bone mesenchymal stem cells which may explain the decreased bone formation in aged apoE(-/-) mice.
Report acceleration of atherogenesis in ApoE-/- mice exposed to acute or low-dose-rate ionizing radiation.
Fondaparinux, the selective FXa (show F10 Proteins) inhibitor, can promote the stability of atherosclerotic lesions in apolipoprotein E-deficient mice.
The literatures were searched extensively and this review was performed to review the signaling pathway factors expression in renal tissue of apoE-knockout mice. [review]
The results suggest that education and female gender, not APOE genotype, may be important as independent strong predictive factors for disease progression in patients with early-onset Alzheimer's disease.
C2238/alphaANP downregulates ApoE in vascular smooth muscle cells through type C natriuretic peptide receptor-dependent activation of Egr-1 (show EGR1 Proteins) and the consequent upregulation of miR199a.
Sporadic Abeta (show APP Proteins) accumulation may be partly associated with increased amyloidogenic APP (show APP Proteins) production, especially in APOE varepsilon4-negative subjects.
The APOE epsilon2 allele increases the risk of Frontotemporal Dementia in ALS patients.
Single-nucleotide polymorphisms in APOE gene is associated with Alzheimer's disease.
Strong association between ApoE e4 allele and AD.
Higher peak velocity-reactivity in APOE epsilon4 carriers suggests vascular compensation for deleterious effects of this known risk allele for Alzheimer's disease and stroke
APOE-epsilon4 carriers showed an inability to effectively modulate posteromedial cortex during scene, but not face and object, working memory and perception.
These results demonstrate that the impact of cerebrovascular risk on cortical thickness integrity may vary by the presence or absence of the APOE-4 allele, a well-known risk factor for Alzheimer's disease.
Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (show APOA1 Proteins) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE, MTP (show MTTP Proteins), and LDLR (show LDLR Proteins), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 Proteins) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (show APOB Proteins)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP Proteins)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3