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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Additionally we are shipping APOE Antibodies (350) and APOE Kits (95) and many more products for this protein.
Showing 10 out of 43 products:
DPP (show DSPP Proteins)-4I, MK0626, but not native incretins has protective effects against AAA (show AAAS Proteins) in Ang II (show AGT Proteins)-infused Apoe/ mice via suppression of inflammation, proteolysis, and fibrosis in the aortic wall
Results suggest that the pathological effects of ApoE4 in astrocytes may be mediated by impaired autophagy and by the concomitant impaired ability of the cells to remove Abeta (show APP Proteins) plaques
Treatment of an Alzheimer's disease mouse model with genistein results in a remarkable and rapid improvement in various parameters of cognition; a lowering of Abeta (show APP Proteins) levels in brain, in the number and the area of amyloid plaques (confirmed in vivo by positron emission tomography) as well as in microglial reactivity; and incubation of primary astrocytes with genistein results in a PPARgamma (show PPARG Proteins)-mediated increased release of ...
Results demonstrate that iron alters ApoE protein levels in neurons and astrocytes, and also affects the secretion of ApoE fragments, show that ApoE mRNA expression is enhanced by iron in astrocytes but not in neurons
Lack of neural compensatory mechanisms of BDNF (show BDNF Proteins) val66met met carriers and APOE E4 carriers in healthy aging, mild cognitive impairment, and Alzheimer's disease
Macrophage IGF1R (show IGF1R Proteins) signaling suppresses macrophage and foam cell accumulation in lesions and reduces plaque vulnerability, providing a novel mechanism whereby IGF-1 (show IGF1 Proteins) exerts antiatherogenic effects in ApoE knockout mice.
This study demonstrated the GFAP (show GFAP Proteins)-ApoE4 mice exhibited motor impairments when compared to GFAP (show GFAP Proteins)-ApoE3 and wild-type mice.
The results of the current study indicated that vaspin (show SERPINA12 Proteins) inhibited the progression of atherosclerotic plaques in apoE(/) mice by inhibiting endoplasmic reticulum stress-induced macrophage apoptosis.
Epigenetic Control of Apolipoprotein E Expression Mediates Gender-Specific Hematopoietic Regulation.
These findings may be clinically relevant because HDL's APOE content associates with CVD risk and ABCA1 (show ABCA1 Proteins) deficiency promotes unregulated cholesterol accumulation in human macrophages.
Study suggested that conventional criteria for Mild Cognitive Impairment may be susceptible to false positive diagnostic errors, and that onset of Abeta (show APP Proteins) accumulation may occur earlier in APOE varepsilon4 carriers compared to non-carriers
The analysis suggested that ApoEepsilon4 mutation was associated with the increased risk of CHD (show CHDH Proteins), while ApoEepsilon2 allele had a decreased risk of CHD (show CHDH Proteins) just in Caucasians.
Data revealed that ApoE e4 allele is associated with increased risk of coronary artery disease (CAD) in Kashmiri population.
Review/Meta-analysis: APOE E2/E2 might be one of the factors affecting warfarin dose requirements. The effect of APOE may vary between ethnicities.
The epsilon4 allele of the APOE gene was significantly associated with both early and late onset Alzheimer's distributions but with opposite effect.
Haplotype analysis reveals a strong association of the interaction of DNMT3B (show DNMT3B Proteins) gene with APOEepsilon4 in a sample of Alzheimer disease patients.
LDLR (show LDLR Proteins) A(+)A(+) genotype, ApoB (show APOB Proteins) X(+) allele and ApoE E4 allele increased the risk of premature coronary artery disease by 1.8, 2.1 and 12.1 respectively.
Study found a significant interaction of age and ApoE genotype on task-related activation bilaterally in anterior cingulate gyrus and superior frontal gyrus, as well as left and right insula. Old age was associated with increased activity in varepsilon4 carriers. Recruitment of neuronal resources resulted in enhanced memory performance in young varepsilon4 carriers.
APOE is involved with late onset Alzheimer's disease. [review]
We evaluated whether APOE is a 'variability gene' for body mass index, depressive symptoms, and cognition (verbal, spatial, attention, working memory, perceptual speed) in twin studies from four countries, and whether it partly represents the 'G' in GxE effects. Results suggested that APOE may represent a 'variability gene' for depressive symptoms and spatial reasoning, but not for BMI or other cognitive measures.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (show APOA1 Proteins) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE, MTP (show MTTP Proteins), and LDLR (show LDLR Proteins), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 Proteins) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (show APOB Proteins)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP Proteins)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3