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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Additionally we are shipping APOE Antibodies (336) and APOE Kits (104) and many more products for this protein.
Showing 10 out of 41 products:
Human APOE Protein expressed in Human - ABIN934462
Krul, Cole: Quantitation of apolipoprotein E. in Methods in enzymology 1996
Epigenetic Control of Apolipoprotein E Expression Mediates Gender-Specific Hematopoietic Regulation.
These findings may be clinically relevant because HDL's APOE content associates with CVD risk and ABCA1 (show ABCA1 Proteins) deficiency promotes unregulated cholesterol accumulation in human macrophages.
study demonstrated ApoE4-containing astrocyte-conditioned media increases mitochondria-associated endoplasmic reticulum membranes (MAM) function relative to ApoE3; data are consistent with a role of upregulated MAM function in the pathogenesis of Alzheimer disease and may help explain the contribution of ApoE4 as a risk factor in the disease
Neurometabolic roles of ApoE and Ldl-R in mouse brain.
Suggest Idol (show MYLIP Proteins) as a gatekeeper of LDLR (show LDLR Proteins)-dependent ApoE and Abeta (show APP Proteins) clearance in the brain and a potential enzyme target for therapeutic intervention in Alzheimer disease.
Systemic administration of irisin (show FNDC5 Proteins) may be protected against endothelial injury and ameliorated atherosclerosis in apoE(-/-) diabetic mice.
NPY (show NPY Proteins) might be involved in the pathogenesis of METH (show MTRR Proteins)-induced atherogenic effects through NPY (show NPY Proteins) Y1 receptor pathway in ApoE knockout mice
Plasmalogen enrichment via batyl alcohol supplementation attenuated atherosclerosis in ApoE- and ApoE/GPx1 (show GPX1 Proteins)-deficient mice.
Cx37 (show GJA4 Proteins) deletion increased the size of atherosclerotic lesions in oscillatory shear stress regions and abrogated the development of a stable plaque phenotype under OSS in ApoE(-/-) mice
When chronic allergic lung inflammation (ALI)and atherosclerosis were produced simultaneously, ALI increased atherosclerotic lesion size, inflammatory cell content, elastin (show ELN Proteins) fragmentation, smooth muscle cell loss, lesion cell proliferation, and apoptosis.
Subjective memory complaints was associated with high Abeta (show APP Proteins) burden, especially in APOEepsilon4 carriers and younger subjects
Carrying APOE*4 alleles increases MetS (show ETV3 Proteins) in a dose-dependent manner, characterizing individual's APOE genotype might help identify at-risk subjects for preventive intervention.
suggested that ApoE may have a role in the pathogenesis and progression of HBV-related liver disease and indicated the possible underlying mechanisms
ApoE mutations may have a role in increasing the development of diabetic nephropathy among the Egyptian individuals.
The data suggest that the APOE-epsilon4 allele is protective against attention deficit and especially against poor working memory in Hepatitis C virus-infected subjects with mild liver disease.
We demonstrated the benefits of a questionnaire-based approach for assessment of lifestyle risk factors to facilitate clinical interpretation of APOE genotyping genetic subgroup of dyslipidemic patients
The possession of the APOE epsilon4 allele has a small, nonsignificant effect on the presence of delirium. It seems that there is no association between APOE and the occurrence of delirium.[review; meta-analysis]
The results of this study shows that the frequency of epsilon4 allele of ApoE is significantly lower among hypertensive patients on hemodialysis with the highest levels of Asymmetric dimethylarginine .
In older surgery patients free of dementia, the findings do not support the hypothesis that the ApoE genotype does not confer either risk or protection in postoperative delirium incidence, severity, or duration.
we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
The molar ratio ApoE/ApoA-I (show APOA1 Proteins) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity
The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE, MTP (show MTTP Proteins), and LDLR (show LDLR Proteins), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism
apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 Proteins) particles, and lipid-free forms were included in cow plasma
after calving the apolipoprotein B(100 (show APOB Proteins)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP Proteins)) and apolipoprotein E messenger RNA abundance were higher in the liver
The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.
In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals
Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world
There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
, apolipoprotein E3