APOE Protein (AA 19-311) (Fc Tag)
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- Target See all APOE Proteins
- APOE (Apolipoprotein E (APOE))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 19-311
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This APOE protein is labelled with Fc Tag.
- Purpose
- Mouse APOE/Apolipoprotein E Protein
- Sequence
- Glu19-Gln311
- Characteristics
- Recombinant Mouse APOE/Apolipoprotein E Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu19-Gln311.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
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Apolipoprotein E (APOE) (AA 19-317) protein (Fc Tag)
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in 20 mM PB, 150 mM NaCl ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- APOE (Apolipoprotein E (APOE))
- Alternative Name
- APOE (APOE Products)
- Synonyms
- ad2 Protein, apoprotein Protein, im:7036787 Protein, wu:fb69a05 Protein, zgc:110064 Protein, apoe Protein, AI255918 Protein, AD2 Protein, LDLCQ5 Protein, LPG Protein, APOEA Protein, Apo-E Protein, apolipoprotein E Protein, apolipoprotein Ea Protein, apoe Protein, apoea Protein, Apoe Protein, APOE Protein
- Background
- Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD).
- Molecular Weight
- 60.7 kDa. Due to glycosylation, the protein migrates to 62-66 kDa based on Tris-Bis PAGE result.
- UniProt
- P08226
- Pathways
- Regulation of Cell Size, Lipid Metabolism
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