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Apolipoprotein E Proteins (APOE)

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Additionally we are shipping APOE Antibodies (353) and APOE Kits (133) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APOE 11816 P08226
APOE 348 P02649
APOE 25728 P02650
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Top APOE Proteins at

Showing 10 out of 50 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Mammalian Cells Mouse His tag   50 μg Log in to see 5 Days
HOST_Human Human His tag   10 μg Log in to see 11 Days
HOST_Human Human Un-conjugated 50 μg Log in to see 2 to 3 Days
HOST_Human Human Un-conjugated   100 μg Log in to see 7 to 9 Days

APOE Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , ,
Human , ,
Rat (Rattus) ,

Top referenced APOE Proteins

  1. Human APOE Primary Antibody for - ABIN934462 : Krul, Cole: Quantitation of apolipoprotein E. in Methods in enzymology 1996 (PubMed)

More Proteins for Apolipoprotein E (APOE) Interaction Partners

Mouse (Murine) Apolipoprotein E (APOE) interaction partners

  1. by comparing the evolution of CIA (show NCOA5 Proteins) between several strains of mutant mice with different levels of serum ApoE and cholesterol, our results demonstrate that both hypercholesterolaemia and ApoE regulate the intensity of in-vivo systemic autoimmune responses.

  2. prolonged treatment of apoE(-/-) mice with Alda-1 led to the beneficial changes in the expression of genes and proteins related to neuroplasticity and mitochondrial function.

  3. clopidogrel can effectively delay the development and progression of 'de-novo' atherosclerosis in ApoE knockout mice.

  4. CCL5 (show CCL5 Proteins) deficiency decreased neointima formation after carotid injury in ApoE-/- mice.

  5. The values in the Apoe-deficient mice were much greater than in the Ldlr (show LDLR Proteins) mice. These findings suggest that Apoe-deficient mice showed increased susceptibility to inflammation-associated colorectal carcinogenesis due to their high reactivity to inflammatory stimuli.

  6. the effect of 25-hydroxyvitamin D-1-alpha-hydroxylase on the atherosclerosis disease both in apolipoprotein (apo) E-/- mice and wild-type mice, was investigated.

  7. DPP (show DSPP Proteins)-4I, MK0626, but not native incretins has protective effects against AAA (show AAAS Proteins) in Ang II (show AGT Proteins)-infused Apoe/ mice via suppression of inflammation, proteolysis, and fibrosis in the aortic wall

  8. Results suggest that the pathological effects of ApoE4 in astrocytes may be mediated by impaired autophagy and by the concomitant impaired ability of the cells to remove Abeta (show APP Proteins) plaques

  9. Treatment of an Alzheimer's disease mouse model with genistein results in a remarkable and rapid improvement in various parameters of cognition; a lowering of Abeta (show APP Proteins) levels in brain, in the number and the area of amyloid plaques (confirmed in vivo by positron emission tomography) as well as in microglial reactivity; and incubation of primary astrocytes with genistein results in a PPARgamma (show PPARG Proteins)-mediated increased release of ...

  10. Results demonstrate that iron alters ApoE protein levels in neurons and astrocytes, and also affects the secretion of ApoE fragments, show that ApoE mRNA expression is enhanced by iron in astrocytes but not in neurons

Human Apolipoprotein E (APOE) interaction partners

  1. we explored the frequency specific effects of ApoE e4 allele on the default mode network (DMN (show SYNM Proteins)) and the salience network (SN) functional connectivity

  2. In cognitively normal older adults, Abeta (show APP Proteins)+ is associated with memory decline in epsilon4 noncarriers; however, the rate of this decline is much slower than that observed in epsilon4 carriers. These data indicate that the processes by which epsilon4 carriage increases the rate of Abeta (show APP Proteins)-related cognitive decline occur in the preclinical stage of Alzheimer disease.

  3. This study showed that APOE genotype affects APOE distribution in human brain samples.

  4. Study found that myoinositol levels are elevated already at asymptomatic stages of Alzheimer disease; myoinositol/creatine concentrations were increased in healthy APOE epsilon4 carriers with normal CSF (show CSF2 Proteins) Abeta42 levels, suggesting that myoinositol levels may reveal regional brain consequences of APOE epsilon4 before detectable amyloid pathology

  5. Thus, the present protocol may facilitate simple, fast and costeffective screening for important SNPs, as demonstrated by the evaluation of the prevalence of ApoE variants in a Han Chinese cohort.

  6. The study suggested that the APOE genotype and haplotype significantly associated with plasma TC and LDL-C level in Vietnamese children. The association of APOE genotype with hypoalphalipoproteinemia was independent of obesity-related traits.

  7. According to multivariate regression logistic analyses of this study, higher cortisol levels, lower high-density lipoprotein (HDL (show HSD11B1 Proteins)-c) and very low-density lipoprotein (VLDL-c), presence of epsilon4 allele of APOE, and aging were associated with cognitive impairment no dementia and dementia.

  8. These findings indicated that variants in TOMM40 (show TOMM40 Proteins)/APOE/APOC1 (show APOC1 Proteins) region might be associated with human longevity. Further studies are needed to identify the causal genetic variants influencing human longevity.

  9. Metaanalysis: the epsilon2 allele in APOE may appear as a risk factor for premature coronary artery disease in Asians while a protective factor in Caucasians and that the epsilon4 allele acted as a genetic risk factor for premature coronary artery disease

  10. APOE rs429358 variant C allele and 4 allele are associated with the anti-epileptic drugs resistance in Han Chinese patients.

Rabbit Apolipoprotein E (APOE) interaction partners

  1. we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.

  2. The molar ratio ApoE/ApoA-I (show APOA1 Proteins) is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.

  3. ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity

  4. The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.

Pig (Porcine) Apolipoprotein E (APOE) interaction partners

  1. These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant

Cow (Bovine) Apolipoprotein E (APOE) interaction partners

  1. Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE, MTP (show MTTP Proteins), and LDLR (show LDLR Proteins), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.

  2. Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism

  3. apoE-containing particles, which increased during the lactating stage, were not associated with HDL (show HSD11B1 Proteins) particles, and lipid-free forms were included in cow plasma

  4. after calving the apolipoprotein B(100 (show APOB Proteins)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (show MTTP Proteins)) and apolipoprotein E messenger RNA abundance were higher in the liver

Chimpanzee Apolipoprotein E (APOE) interaction partners

  1. The study found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.

  2. ApoE evolution and very likely the evolution of other apolipoproteins are influenced by feeding environment and diet of humans, chimpanzees and various other species.

Rhesus Monkey Apolipoprotein E (APOE) interaction partners

  1. In the hippocampus APOE protein levels were higher in good spatial performers than poor spatial performers animals

  2. Allele frequencies of the ApoE gene found show that allele epsilon3 has one of the highest frequencies and epsilon4 allele one of the lowest compared to other population groups in the world

  3. There was significantly more apoE immunoreactivity in the prefrontal cortex and hippocampus of aged animals compared to adult or middle-aged animals.

APOE Protein Profile

Protein Summary

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Gene names and symbols associated with Apolipoprotein E Proteins (APOE)

  • apolipoprotein E (apoe)
  • apolipoprotein Ea (apoea)
  • apolipoprotein E (Apoe)
  • apolipoprotein E (APOE)
  • AD2 protein
  • AI255918 protein
  • Apo-E protein
  • apoe protein
  • APOEA protein
  • apoprotein protein
  • im:7036787 protein
  • LDLCQ5 protein
  • LPG protein
  • wu:fb69a05 protein
  • zgc:110064 protein

Protein level used designations for Apolipoprotein E Proteins (APOE)

apolipoprotein E , ApoE-1 , apo-E , apolipoprotein E3

394678 Xenopus (Silurana) tropicalis
553587 Danio rerio
100136023 Oncorhynchus mykiss
100380959 Xenopus laevis
11816 Mus musculus
348 Homo sapiens
100009337 Oryctolagus cuniculus
25728 Rattus norvegicus
397576 Sus scrofa
100731633 Cavia porcellus
281004 Bos taurus
476438 Canis lupus familiaris
449586 Pan troglodytes
714623 Macaca mulatta
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