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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. Additionally we are shipping CTCF Antibodies (88) and CTCF Kits (7) and many more products for this protein.
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Human CTCF Protein expressed in Wheat germ - ABIN1350629
Shukla, Kavak, Gregory, Imashimizu, Shutinoski, Kashlev, Oberdoerffer, Sandberg, Oberdoerffer: CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. in Nature 2011
Show all 3 references for ABIN1350629
We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (show RUNX1 Proteins) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF (show C11orf9 Proteins) functional interactions in the orchestration of myogenesis.
TGF-beta (show TGFB1 Proteins)/beta2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.
Results indicate that CTCF binding polarity plays a functional role in the formation of higher-order chromatin structure.
Firre is X-linked and expressed from a macrosatellite repeat locus associated with a cluster of CTCF and cohesin binding sites, and is preferentially located adjacent to the nucleolus
CTCF controls the homeostatic maintenance and migration of Langerhans cells.
MyoD (show MYOD1 Proteins) affects chromatin looping at CCCTC-binding factor-binding sites represents the first evidence that a differentiation factor regulates chromatin-loop dynamics
Findings establish CTCF as a prominent tumor-suppressor gene and point to CTCF-mediated epigenetic stability as a major barrier to neoplastic progression.
CTCF is recruited in a locus-specific manner and CTCF-RNA interactions may be involved in long-range chromosomal interactions.
TET1 (show TET1 Proteins)/DNA methylation (show HELLS Proteins)-dependent nucleosome repositioning is the main mechanism that drives differential CTCF binding site selection during stem cell development.
NURF regulation occurs partly through physical and functional interactions with the ubiquitous and multivalent factors Ctcf and cohesin
CTCF is involved in regulating endocrine function of pancreatic islet cells by suppression of Pax6 (show PAX6 Proteins) expression.
Study described the formation of mutually exclusive complexes of ENY2 (show ENY2 Proteins) with insulator proteins and Sgfl1-a component of the SAGA complex, direct binding partner for ENY2 (show ENY2 Proteins)
This is supported by the depletion of CTCF in glioblastoma cells affecting the expression levels of NOTCH2 (show NOTCH2 Proteins) as a target of miR (show MLXIP Proteins)-181c. CONCLUSION: Together, our results point to the epigenetic role of CTCF in the regulation of microRNAs implicated in tumorigenesis
Our data show that aberrant epigenetic inactivation of DUSP2 occurs in carcinogenesis and that CTCF is involved in the epigenetic regulation of DUSP2 expression.
Mutational analysis highlighted a potential role for CTCF, a crucial regulator of long-range chromatin interactions, in head and neck cancer progression.
CTCF and cohesins shape the genome during evolution. (Review)
The action of SNF2H (show SMARCA5 Proteins) at CTCF sites is functionally important as depletion of CTCF or SNF2H (show SMARCA5 Proteins) affects transcription of a common group of genes.
CSB (show ERCC6 Proteins) and CTCF can regulate each other's chromatin association, thereby modulating chromatin structure and coordinating gene expression in response to oxidative stress.
CTCF binds to the provirus at a sharp border in epigenetic modifications in the pX region of the HTLV-1 provirus in T cells naturally infected with HTLV-1. This may cause widespread abnormalities in host cell chromatin structure and gene expression.
CTCF/cohesin coordinates HOXA cluster higher-order chromatin structure and expression during development
CTCF has a role in regulating SLC45A3-ELK4 (show ELK4 Proteins) Chimeric RNA
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor