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Cadherin 1, Type 1, E-Cadherin (Epithelial) Proteins (CDH1)

CDH1 is a classical cadherin from the cadherin superfamily. Additionally we are shipping E-cadherin Antibodies (791) and E-cadherin Kits (78) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CDH1 444901  
CDH1 12550 P09803
CDH1 999 P12830
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Top E-cadherin Proteins at

Showing 10 out of 39 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
HOST_HEK-293 Cells Human His tag Human E-Cadherin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%. 100 μg Log in to see 2 to 3 Days
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days

CDH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,
Mouse (Murine) , ,
Human , , , , , , , ,
, , , , ,

Top referenced E-cadherin Proteins

  1. Human E-cadherin Protein expressed in Human Cells - ABIN2002344 : Berx, Staes, van Hengel, Molemans, Bussemakers, van Bokhoven, van Roy: Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1). in Genomics 1995 (PubMed)
    Show all 5 references for ABIN2002344

  2. Human E-cadherin Protein expressed in Human Cells - ABIN2002342 : Yoshiura, Kanai, Ochiai, Shimoyama, Sugimura, Hirohashi: Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. in Proceedings of the National Academy of Sciences of the United States of America 1995 (PubMed)
    Show all 5 references for ABIN2002342

  3. Rat (Rattus) E-cadherin Protein expressed in Human Cells - ABIN2009409 : Becker, Atkinson, Reich, Becker, Nekarda, Siewert, Höfler: E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. in Cancer research 1994 (PubMed)
    Show all 5 references for ABIN2009409

  4. Mouse (Murine) E-cadherin Protein expressed in Human Cells - ABIN2008138 : Marambaud, Shioi, Serban, Georgakopoulos, Sarner, Nagy, Baki, Wen, Efthimiopoulos, Shao, Wisniewski, Robakis: A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. in The EMBO journal 2002 (PubMed)
    Show all 5 references for ABIN2008138

  5. Human E-cadherin Protein expressed in HEK-293 Cells - ABIN2180987 : Agiostratidou, Muros, Shioi, Marambaud, Robakis: The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors. in Journal of neurochemistry 2006 (PubMed)
    Show all 4 references for ABIN2180987

  6. Human E-cadherin Protein expressed in Wheat germ - ABIN3013372 : Tsunematsu, Takihara, Ishimaru, Pagano, Takata, Kudo: Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis. in Nature communications 2013 (PubMed)

More Proteins for Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) Interaction Partners

Xenopus laevis Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. E-cadherin has a role in cranial neural crest migration in Xenopus laevis

  2. the switch from E- to N-cadherin (show CDH2 Proteins) during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.

  3. Moderate attenuation of C-cadherin function affects cell adhesion but not gastrulation.

  4. Because paraxial protocadherin and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.

  5. The functional and physical relationships between PAPC, FLRT3, and C-cadherin, was investigated.

  6. PAPC mediates these functions by down-regulating the adhesion activity of C-cadherin.

  7. Results suggest that the basis for cell segregation during morphogenesis does not map exclusively to protein-level differences in E-, N-, or C-cadherin adhesion.

  8. G-protein-coupled receptors control cortical actin assembly by controlling the amount of cadherin expressed on the cell surface.

  9. Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region

  10. Data show that the intracellular domain of PAPC (Protocadherin) interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.

Mouse (Murine) Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. These observations suggest that the overexpression of CatE (show CTSE Proteins) interferes with neuronal differentiation of P19 (show CDKN2D Proteins) cells through an impairment of cell aggregate formation, possibly through proteolytic degradation of N-cadherin (show CDH2 Proteins).

  2. E-cadherin-mediated cell-cell contacts can modulate osteoclast-specific gene expression and prompt differentiating osteoclast precursors toward migratory and fusion activities.

  3. These results provide a new mechanism by which LXA4 inhibits LPS (show TLR4 Proteins)-induced ALI through Nrf2 (show NFE2L2 Proteins)-mediated E-cadherin expression

  4. Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis.

  5. E-cadherin expression regulates inflammatory mediators in macrophages.

  6. Increased expression of E-cadherin binds to and sequesters beta-catenin (show CTNNB1 Proteins) away from downstream Wnt (show WNT2 Proteins) signaling proteins.

  7. Results suggest a regulatory function of E-cadherin that modulates Nrg1 (show NRG1 Proteins) signaling and promotes Schwann cell myelin formation

  8. Both catalytic and non-catalytic APC (show APC Proteins)/C-Fzr1/Cdh1 (show FZR1 Proteins)-mediated activities of PTEN are required for stalk cells' proliferative arrest. Findings implicate the PTEN-APC (show APC Proteins)/C-Fzr1/Cdh1 (show FZR1 Proteins) hub in angiogenesis.

  9. we conclude that APC (show APC Proteins)/C(Cdh1) controls CK1 (show KRT1 Proteins) delta levels to balance proliferation and cell-cycle exit in the developing CNS

  10. During submandibular gland development, a Hippo pathway effector, TAZ (show TAZ Proteins), becomes increasingly phosphorylated and associated with E-cadherin and alpha-catenin (show CTNNA1 Proteins), consistent with the activation of Hippo signaling. (Hippo)

Human Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. The CDH1 -160C/A polymorphism does not seem to significantly influence the expression of E-cadherin in PA and ACC of salivary glands.

  2. DNA methylation (show HELLS Proteins) level was negatively correlated with mRNA expression of the E-Cadherin gene. Methylation in tumor tissues was significantly higher than that in tumor adjacent tissues (P < 0.05).

  3. Immunostaining allowed the identification of specific cell types with E-cadherin, p53 (show TP53 Proteins), and inhibin-alpha (show INHA Proteins) expression in all cases.

  4. CDH1 -160C/A polymorphism is associated with breast cancer.

  5. Bmi-1 (show BMI1 Proteins) promotes the invasion and migration of colon cancer stem cells through the downregulation of E-cadherin.

  6. The CDH1 downregulation acted as an independent prognostic biomarker in cytogenetically normal acute myeloid leukemia (show BCL11A Proteins) (CN-AML (show RUNX1 Proteins)) patients.

  7. Our study demonstrates that the CDH1 polymorphisms were significantly associated with the risk of nonsyndromic cleft lip with or without cleft palate in the northern Chinese Han population

  8. Low expression of CDH1 is associated with invasion in non-small cell lung cancer.

  9. Low expression of E-cadherin is associated with bladder cancer.

  10. we concluded that the CDH1 -472delA and -160C>A polymorphisms are not associated with diffuse (DGC (show GGCX Proteins)) or intestinal (IGC) types of gastric cancer in patients from western Mexico.

Pig (Porcine) Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. E-cadherin mRNA/protein were up-regulated in all flutamide-treated corpus luteum of mid- and late pregnancy.

  2. In pig kidney, strong E-cadherin expression was observed in the basolateral plasma membrane of the tubular epithelial cells. E-cadherin immunolabeling was not detected in glomeruli or blood vessels of pig kidney.

  3. Localisation of NANOG (show NANOG Proteins), OCT4 (show POU5F1 Proteins), and E-CADHERIN in porcine pre- and peri (show PLIN1 Proteins)-implantation embryos.

  4. The epiblast expressed epithelial markers, MUC1 (show MUC1 Proteins) and E-CADHERIN, and the pluripotency markers, DNMT3B (show DNMT3B Proteins) and CRIPTO (show TDGF1 Proteins).

Cow (Bovine) Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. Transfection of zygotes with 100 and 200 nM E-cadherin siRNA led to a 72 and 38% reduction, respectively, in E-cadherin mRNA relative abundance in Day 7 blastocysts compared with controls.

  2. E-cadherin and beta-catenin (show CTNNB1 Proteins) were distributed not only at the cell to cell boundary but throughout the cytoplasm in binucleate trophoblast cells

  3. Results describe the effect of suppression of connexin 43 (show GJA1 Proteins) and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.

Zebrafish Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. E-cadherin mRNA coinjection demonstrated the specificity of cdh1 morpholino oligonucleotides-induced defects

  2. Results suggest that Wnt11 (show WNT11 Proteins) controls tissue morphogenesis by modulating E-cadherin-mediated cell cohesion through Rab5c (show Rab5c Proteins), a novel mechanism of Wnt (show WNT2 Proteins) signaling in gastrulation.

E-cadherin (CDH1) Protein Profile

Protein Summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

Gene names and symbols associated with CDH1

  • cadherin 3, type 1, P-cadherin (placental) (cdh3-a)
  • Aerobic running capacity QTL 1 (Arunc1)
  • cadherin 1 (Cdh1)
  • cadherin 1, type 1, E-cadherin (epithelial) (CDH1)
  • cadherin 1, type 1, E-cadherin (epithelial) (Cdh1)
  • cadherin 1, type 1, E-cadherin (epithelial) (cdh1)
  • E-cadherin-like (LOC100356548)
  • si:busm1-180o5.2 (si:busm1-180o5.2)
  • AA960649 protein
  • arc-1 protein
  • Arc1 protein
  • b-cadherin protein
  • cadherin-1 protein
  • cd324 protein
  • cdh1 protein
  • cdh1-a protein
  • cdhc-A protein
  • cdhe protein
  • cdhp protein
  • E-cad protein
  • E-cadherin protein
  • ecad protein
  • hjmd protein
  • L-CAM protein
  • LCAM protein
  • pcad protein
  • si:dz180o5.2 protein
  • Um protein
  • UVO protein
  • uvomorulin protein
  • xb-cad protein
  • XB-cadherin protein
  • XBcad protein
  • xcdh1 protein
  • XTCAD-1 protein

Protein level used designations for CDH1

C-cadherin (EP-cadherin) , EP-cadherin , cadherin 1, type 1, E-cadherin (epithelial) , ARC-1 , E-cadherin , cadherin-1 , epithelial cadherin , uvomorulin , CAM 120/80 , E-Cadherin , cadherin 1, E-cadherin (epithelial) , calcium-dependent adhesion protein, epithelial , cell-CAM 120/80 , L-CAM , liver cell adhesion molecule , liver cell adhesion protein , xTCAD-1 , Epithelial cadherin , hypothetical protein LOC368517

394290 Xenopus laevis
444901 Rattus norvegicus
12550 Mus musculus
83502 Rattus norvegicus
999 Homo sapiens
442858 Canis lupus familiaris
100048953 Sus scrofa
282637 Bos taurus
415860 Gallus gallus
101095391 Felis catus
101119747 Ovis aries
100726210 Cavia porcellus
100337618 Xenopus laevis
100174439 Pongo abelii
100356548 Oryctolagus cuniculus
368517 Danio rerio
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