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Chemokine (C-X-C Motif) Receptor 4 Proteins (CXCR4)

CXCR4 encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. Additionally we are shipping CXCR4 Antibodies (468) and CXCR4 Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CXCR4 12767 P70658
CXCR4 60628  
CXCR4 7852 P61073
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Top CXCR4 Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag Human CXCR4, GST Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 50%. 50 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_HEK-293 Cells Human Fc Tag Human CXCR4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 2 to 3 Days
$330.00
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
$341.00
Details
Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human GST tag   0.05 mg Log in to see 2 to 3 Days
$515.63
Details
HOST_HEK-293 Human Fc Tag   0.05 mg Log in to see 2 to 3 Days
$584.38
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details

CXCR4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus)
Human , , , , ,
, , ,

Top referenced CXCR4 Proteins

  1. Human CXCR4 Protein expressed in Escherichia coli (E. coli) - ABIN2180954 : Saini, Marchese, Majetschak: CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin. in The Journal of biological chemistry 2010 (PubMed)

More Proteins for Chemokine (C-X-C Motif) Receptor 4 (CXCR4) Interaction Partners

Medaka Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. bilateral lineup in the trunk before PGC (show PGC Proteins) migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor (show CCR1 Proteins) gene cxcr4b

Mouse (Murine) Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. CXCR4 expression was significantly associated with higher rate of metastasis and poor prognosis in patients with bone and soft tissue sarcoma. (Meta-analysis)

  2. the present study indicates that the CXCL12 (show CXCL12 Proteins)/CXCR4 signaling pathway is important during the development of cochleae in neonatal mice.

  3. crosstalk between astrocytic CXCL12 (show CXCL12 Proteins) and microglial CXCR4 in the pathogenesis of neuropathic pain.

  4. Results from using a plasmid transient expression of shRNA antiCXR4 shown that CXCR4 plays a critical role in the initial stages of development of murine melanoma B16F10 melanoma.

  5. DPP-4 (show DPP4 Proteins) inhibition may have direct protective effects on the post-myocardial infarction heart by inducing an antiapoptotic effect and inhibiting a decrease in vessel number through the SDF-1a/CXCR4-mediated STAT3 (show STAT3 Proteins) signaling pathway.

  6. confirm a pivotal role of the SDF-1/CXCR4/CXCR7 axis for chronic allograft vasculopathy development

  7. CXCR4 has an important role in endothelial progenitor cells migration at the ischemic site.

  8. CXCR4/CXCL12 (show CXCL12 Proteins) signaling may control movement of epithelial progenitors from the dental stem cell niche.

  9. our present study provided evidence that SDF-1 (show CXCL12 Proteins) mediated CSCs migration through CXCR4 and CXCR7 via MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) and PI3K/Akt (show AKT1 Proteins) pathway

  10. Endothelial CXCR4 is negatively regulated by miR (show MLXIP Proteins)-139-5p, whose transcription is in turn induced by laminar flow and APLN (show APLN Proteins)/APLNR (show APLNR Proteins) signalling.

Human Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. mass spectrum followed by immunoprecipitation identified non-muscle myosin heavy chain-IIA (NMMHC-IIA (show MYH9 Proteins)) as the CXCR4-interacting protein. Furthermore, pharmaceutical inhibition of NMMHC-IIA (show MYH9 Proteins) by blebbistatin dampened the nuclear translocation of CXCR4 as well as the metastatic capacity of RCC (show XRCC1 Proteins) cells

  2. CXCL12 (show CXCL12 Proteins) may be an effective diagnostic marker for papillary thyroid carcinoma, and CXCL12 (show CXCL12 Proteins)/CXCR4/CXCR7 axis may contribute to thyroid cancer development by regulating cancer cell migration and invasion via AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins) signaling and MMP-2 (show MMP2 Proteins) activation.

  3. Higher percentage of CXCR4-expressing lung metastatic cells compared to the corresponding primary tumors point to important functions of the CXCL12 (show CXCL12 Proteins)/CXCR4 axis in late steps of metastasis

  4. we found that CXCR4-CXCL12 (show CXCL12 Proteins)/AKT (show AKT1 Proteins) axis regulates RhoA (show RHOA Proteins), Rac-1, and Cdc42 (show CDC42 Proteins) to modulate cell invasion and tumor metastasis. Together, these results demonstrate a role for CXCR4 in ESCC metastasis and progression and suggest potential targets for therapeutic intervention.

  5. MiR (show MLXIP Proteins)-381 was predicted as a regulatory miRNA of CXCR4 in breast cancer.

  6. CXCR4 gene polymorphism associated with increase risk of cancer especially among Asian ethnicity.

  7. The endometrial tissue showed significantly lower levels of miR (show MLXIP Proteins)-200b, miR (show MLXIP Proteins)-15a-5p, miR (show MLXIP Proteins)-19b-1-5p, miR (show MLXIP Proteins)-146a-5p, and miR (show MLXIP Proteins)-200c, and higher levels of miR-16 (show GDE1 Proteins)-5p, miR (show MLXIP Proteins)-106b-5p, and miR (show MLXIP Proteins)-145-5p. VEGFA (show VEGFA Proteins) was significantly upregulated, whereas EGFR2, PTEN, and CXCR4 were markedly downregulated, in the endometriotic tissues compared to that in the normal endometrial tissues

  8. CXCR4 overexpression promoted mesenchymal stem cell retention within the intervertebral disc and enhanced the stem cell-based intervertebral disc regeneration

  9. Both CXCR4 and MMP9 (show MMP9 Proteins) were independent predictors for overall survival and metastasis-free survival by Cox (show COX8A Proteins) multivariate analysis, and high expression for both CXCR4 and MMP9 (show MMP9 Proteins) were even more significant and better biomarkers for osteosarcoma metastasis and survival. The combination of CXCR4 and MMP9 (show MMP9 Proteins) high expression is very likely to be a valuable independent predictor of lung metastasis and survival in osteosarcoma patients

  10. The SDF-1 (show CXCL12 Proteins)/CXCR4 chemokine (show CCL1 Proteins) axis plays a key role in UM cell proliferation and migration.

Pig (Porcine) Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. CXCR4 controls leukocyte mobilization after trauma.

  2. The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1 (show CXCL12 Proteins)/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.

  3. reports transmural and perivascular expression patterns of chemokines CCL2 (show CCL2 Proteins) and CXCL2 (show CXCL2 Proteins) and of chemokine (show CCL1 Proteins) receptors CCR2 (show CCR2 Proteins), CCR5, and CXCR4 following coronary angioplasty

Xenopus laevis Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

Cow (Bovine) Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. There is a potential link between follicular SDF1 (show CXCL12 Proteins)/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.

  2. The combination of low expression of CXCR4 and high expression of IL-10 (show IL10 Proteins) might be closely concerned with some bias for the production of PI calves.

Rhesus Monkey Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. The increased CXCR4 and CXCR7 expression resulted in increased SDF-1 (show CXCL12 Proteins)-induced RF/6A cell migration and tube formation.

  2. The CXCR7/CXCR4/CXCL12 (show CXCL12 Proteins) axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.

  3. These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Proteins), CXCR4, and TGFB1 (show TGFB1 Proteins) expression and inhibiting choroidl endothelial cell proliferation.

  4. Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively

Zebrafish Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.

  2. SDF1a directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7.

  3. Hoxb8a is induced by and cooperates with Wnt (show WNT2 Proteins) signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.

  4. Expression of Cxcr4 and Cxcl12 (show CXCL12 Proteins) in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12 (show CXCL12 Proteins)/Cxcr4 pair in brain development and functioning.

  5. show that inactivation of the estrogen receptor ESR1 (show ESR1 Proteins) results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 (show ESR1 Proteins) overexpression results in a reciprocal reduction in the domain of cxcr4b expression.

  6. Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.

  7. A CXCR4-like chemokine receptor (show CCR1 Proteins) is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1 (show CXCL12 Proteins)-CXCR4 system.

  8. Knocking down CXCR4 results in severe defects in primordial germ cell migration.

  9. SDF-1 (show CXCL12 Proteins)/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.

  10. chemokine (show CCL1 Proteins) signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish

CXCR4 Protein Profile

Protein Summary

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with CXCR4

  • chemokine (C-X-C motif) receptor 4 (cxcr4)
  • chemokine (C-X-C motif) receptor 4 (CXCR4)
  • chemokine (C-X-C motif) receptor 4 (Cxcr4)
  • chemokine (C-X-C motif) receptor 4 (cxcr4-b)
  • chemokine (C-X-C motif), receptor 4b (cxcr4b)
  • neuropeptide Y receptor type 3 (CXCR4)
  • cb403 protein
  • CD184 protein
  • Cmkar4 protein
  • CXC-R4 protein
  • CXC-R4-B protein
  • CXCR-4 protein
  • CXCR-4-B protein
  • CXCR4 protein
  • D2S201E protein
  • FB22 protein
  • HM89 protein
  • HSY3RR protein
  • LAP3 protein
  • LCR1 protein
  • LESTR protein
  • NPY3R protein
  • NPYR protein
  • NPYRL protein
  • NPYY3R protein
  • PB-CKR protein
  • PBSF/SDF-1 protein
  • Sdf1r protein
  • WHIM protein
  • xcxcr4 protein
  • zgc:109863 protein

Protein level used designations for CXCR4

C-X-C chemokine receptor type 4 , SDF-1 receptor , Stromal cell-derived factor 1 receptor , chemokine (C-X-C motif) receptor 4 , CXC-R4 , CXCR-4 , chemokine (C-X-C) receptor 4 , chemokine receptor 4 , fusin , leukocyte-derived seven transmembrane domain receptor , leukocyte-expressed seven-transmembrane-domain , pre-B-cell-derived chemokine receptor , stromal cell-derived factor 1 receptor , CXC chemokine receptor , LESTR , chemokine receptor (LCR1) , CD184 antigen , leukocyte-derived seven-transmembrane-domain receptor , lipopolysaccharide-associated protein 3 , neuropeptide Y receptor Y3 , seven transmembrane helix receptor , seven-transmembrane-segment receptor, spleen , C-X-C chemokine receptor type 4-B , SDF-1 receptor B , SDF-1 receptor-B , Stromal cell-derived factor 1 receptor-B , stromal cell-derived factor 1 receptor B , LCR1 , chemokine receptor CXCR4 , CXC chemokine receptor 4 , ody , odysseus

GENE ID SPECIES
100038176 Xenopus (Silurana) tropicalis
100049444 Oryzias latipes
100346189 Oryctolagus cuniculus
100451032 Pongo abelii
100604120 Nomascus leucogenys
12767 Mus musculus
60628 Rattus norvegicus
7852 Homo sapiens
396659 Sus scrofa
380373 Xenopus laevis
281736 Bos taurus
493676 Felis catus
483900 Canis lupus familiaris
707329 Macaca mulatta
395324 Gallus gallus
100126711 Papio anubis
450130 Pan troglodytes
114447 Danio rerio
443532 Ovis aries
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