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Chemokine (C-X-C Motif) Receptor 4 Proteins (CXCR4)

CXCR4 encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. Additionally we are shipping CXCR4 Antibodies (466) and CXCR4 Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CXCR4 12767 P70658
CXCR4 60628  
CXCR4 7852 P61073
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Top CXCR4 Proteins at

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag Human CXCR4, GST Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 50%. 50 μg Log in to see 2 to 3 Days
HOST_HEK-293 Cells Human Fc Tag Human CXCR4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 2 to 3 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human GST tag   0.05 mg Log in to see 2 to 3 Days
HOST_HEK-293 Human Fc Tag   0.05 mg Log in to see 2 to 3 Days
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days

CXCR4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus)
Human , , , , ,
, , ,

Top referenced CXCR4 Proteins

  1. Human CXCR4 Protein expressed in Escherichia coli (E. coli) - ABIN2180954 : Saini, Marchese, Majetschak: CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin. in The Journal of biological chemistry 2010 (PubMed)

More Proteins for Chemokine (C-X-C Motif) Receptor 4 (CXCR4) Interaction Partners

Medaka Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. bilateral lineup in the trunk before PGC (show PGC Proteins) migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor (show CCR1 Proteins) gene cxcr4b

Mouse (Murine) Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. crosstalk between astrocytic CXCL12 (show CXCL12 Proteins) and microglial CXCR4 in the pathogenesis of neuropathic pain.

  2. Results from using a plasmid transient expression of shRNA antiCXR4 shown that CXCR4 plays a critical role in the initial stages of development of murine melanoma B16F10 melanoma.

  3. DPP-4 (show DPP4 Proteins) inhibition may have direct protective effects on the post-myocardial infarction heart by inducing an antiapoptotic effect and inhibiting a decrease in vessel number through the SDF-1a/CXCR4-mediated STAT3 (show STAT3 Proteins) signaling pathway.

  4. confirm a pivotal role of the SDF-1/CXCR4/CXCR7 axis for chronic allograft vasculopathy development

  5. CXCR4 has an important role in endothelial progenitor cells migration at the ischemic site.

  6. CXCR4/CXCL12 (show CXCL12 Proteins) signaling may control movement of epithelial progenitors from the dental stem cell niche.

  7. our present study provided evidence that SDF-1 (show CXCL12 Proteins) mediated CSCs migration through CXCR4 and CXCR7 via MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) and PI3K/Akt (show AKT1 Proteins) pathway

  8. Endothelial CXCR4 is negatively regulated by miR (show MLXIP Proteins)-139-5p, whose transcription is in turn induced by laminar flow and APLN (show APLN Proteins)/APLNR (show APLNR Proteins) signalling.

  9. CXCR4 signaling has a role in radiation-induced lung damage that promotes breast cancer lung-metastasis

  10. Splenic TFF2 (show TFF2 Proteins), a secreted anti-inflammatory peptide, is released by vagally modulated memory T cells to suppress the expansion of myeloid-derived suppressor cells through CXCR4.

Human Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. In GNC analysis, SNAI2 (show SNAI2 Proteins) mRNA gene but not ITGA5 (show ITGA5 Proteins), RGS2 (show RGS2 Proteins) and PLEK2 (show PLEK2 Proteins) was dependent on the signaling pathway of CXCR4.

  2. The CXCR4 genotype C>T of rs2228014 appeared to correlate with acute myeloid leukemia (show BCL11A Proteins) risk, but played no role in leukemia cells invading the bloodstream.

  3. High CXCR4 expression in primary breast tumors (PTs (show PTS Proteins)) was found to be associated with luminal A type tumor, suggesting more favorable outcome. In contrast, CCR7 (show CCR7 Proteins) and FOXP3 (show FOXP3 Proteins) expressions in PTs (show PTS Proteins) represented luminal B tumors, pointing to more aggressive tumor behavior. Maspin (show SERPINB5 Proteins) expression did not differ between luminal types.

  4. Exhibiting similar power of significance compared to CXCR3 (show CXCR3 Proteins), CXCR4 expression also served as a predictor for clinical outcome in chronic lymphocytic leukemia patients.

  5. Exposure of CD133+ cells isolated from cord blood to PMPs with 10 mug/ml concentration increased the expression of CXCR4 surface marker significantly.

  6. These results suggested that RTN3 (show RTN3 Proteins) modulates primordial germ cell migration through interaction with, and regulation of, CXCR4.

  7. we observed time points where surface CXCR4 appeared fully occupied but MEDI3185 was not detectable in serum. These paradoxical results represented a type of assay interference, and by comparing pharmacokinetic, ADA (show ADA Proteins) and total CXCR4 results, the most likely reason for the free CXCR4 results was the emergence of neutralizing anti-drug antibodies (ADA (show ADA Proteins)).

  8. Our study panned out new CXCR4 mutations in Waldenstrom macroglobulinemia and identified a specific signature associated to CXCR4(mut (show MUT Proteins)), characterized with complex genomic aberrations among MYD88L265P Waldenstrom macroglobulinemia.

  9. Data show that the three G protein-coupled receptor (show ADRA1A Proteins) CXCR4 i-bodies AM3-114, AM4-272, and AM3-523 revealed binding deep in the binding pocket of the receptor.

  10. CXCR4 was co-expressed with all investigated neural and embryonic stem cell markers in both primary and recurrent tissues, whereas CXCR7 was mostly found on stem cell marker-negative cells, but was co-expressed with KLF-4 (show KLF4 Proteins) on a distinct GBM cell subpopulation

Pig (Porcine) Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. CXCR4 controls leukocyte mobilization after trauma.

  2. The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1 (show CXCL12 Proteins)/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.

  3. reports transmural and perivascular expression patterns of chemokines CCL2 (show CCL2 Proteins) and CXCL2 (show CXCL2 Proteins) and of chemokine (show CCL1 Proteins) receptors CCR2 (show CCR2 Proteins), CCR5, and CXCR4 following coronary angioplasty

Xenopus laevis Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

Cow (Bovine) Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. There is a potential link between follicular SDF1 (show CXCL12 Proteins)/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.

  2. The combination of low expression of CXCR4 and high expression of IL-10 (show IL10 Proteins) might be closely concerned with some bias for the production of PI calves.

Rhesus Monkey Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. The increased CXCR4 and CXCR7 expression resulted in increased SDF-1 (show CXCL12 Proteins)-induced RF/6A cell migration and tube formation.

  2. The CXCR7/CXCR4/CXCL12 (show CXCL12 Proteins) axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.

  3. These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Proteins), CXCR4, and TGFB1 (show TGFB1 Proteins) expression and inhibiting choroidl endothelial cell proliferation.

  4. Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively

Zebrafish Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.

  2. SDF1a directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7.

  3. Hoxb8a is induced by and cooperates with Wnt (show WNT2 Proteins) signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.

  4. Expression of Cxcr4 and Cxcl12 (show CXCL12 Proteins) in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12 (show CXCL12 Proteins)/Cxcr4 pair in brain development and functioning.

  5. show that inactivation of the estrogen receptor ESR1 (show ESR1 Proteins) results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 (show ESR1 Proteins) overexpression results in a reciprocal reduction in the domain of cxcr4b expression.

  6. Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.

  7. A CXCR4-like chemokine receptor (show CCR1 Proteins) is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1 (show CXCL12 Proteins)-CXCR4 system.

  8. Knocking down CXCR4 results in severe defects in primordial germ cell migration.

  9. SDF-1 (show CXCL12 Proteins)/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.

  10. chemokine (show CCL1 Proteins) signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish

CXCR4 Protein Profile

Protein Summary

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with CXCR4

  • chemokine (C-X-C motif) receptor 4 (cxcr4)
  • chemokine (C-X-C motif) receptor 4 (CXCR4)
  • chemokine (C-X-C motif) receptor 4 (Cxcr4)
  • chemokine (C-X-C motif) receptor 4 (cxcr4-b)
  • chemokine (C-X-C motif), receptor 4b (cxcr4b)
  • neuropeptide Y receptor type 3 (CXCR4)
  • cb403 protein
  • CD184 protein
  • Cmkar4 protein
  • CXC-R4 protein
  • CXC-R4-B protein
  • CXCR-4 protein
  • CXCR-4-B protein
  • CXCR4 protein
  • D2S201E protein
  • FB22 protein
  • HM89 protein
  • HSY3RR protein
  • LAP3 protein
  • LCR1 protein
  • LESTR protein
  • NPY3R protein
  • NPYR protein
  • NPYRL protein
  • NPYY3R protein
  • PB-CKR protein
  • PBSF/SDF-1 protein
  • Sdf1r protein
  • WHIM protein
  • xcxcr4 protein
  • zgc:109863 protein

Protein level used designations for CXCR4

C-X-C chemokine receptor type 4 , SDF-1 receptor , Stromal cell-derived factor 1 receptor , chemokine (C-X-C motif) receptor 4 , CXC-R4 , CXCR-4 , chemokine (C-X-C) receptor 4 , chemokine receptor 4 , fusin , leukocyte-derived seven transmembrane domain receptor , leukocyte-expressed seven-transmembrane-domain , pre-B-cell-derived chemokine receptor , stromal cell-derived factor 1 receptor , CXC chemokine receptor , LESTR , chemokine receptor (LCR1) , CD184 antigen , leukocyte-derived seven-transmembrane-domain receptor , lipopolysaccharide-associated protein 3 , neuropeptide Y receptor Y3 , seven transmembrane helix receptor , seven-transmembrane-segment receptor, spleen , C-X-C chemokine receptor type 4-B , SDF-1 receptor B , SDF-1 receptor-B , Stromal cell-derived factor 1 receptor-B , stromal cell-derived factor 1 receptor B , LCR1 , chemokine receptor CXCR4 , CXC chemokine receptor 4 , ody , odysseus

100038176 Xenopus (Silurana) tropicalis
100049444 Oryzias latipes
100346189 Oryctolagus cuniculus
100451032 Pongo abelii
100604120 Nomascus leucogenys
12767 Mus musculus
60628 Rattus norvegicus
7852 Homo sapiens
396659 Sus scrofa
380373 Xenopus laevis
281736 Bos taurus
493676 Felis catus
483900 Canis lupus familiaris
707329 Macaca mulatta
395324 Gallus gallus
100126711 Papio anubis
450130 Pan troglodytes
114447 Danio rerio
443532 Ovis aries
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