CXCR4 Protein

Catalog No. ABIN7491625

Product Details

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Protein Type: Synthetic

Origin: Human

Source: HEK-293 Cells

Purpose: Human CXCR4 full length protein-synthetic nanodisc

Characteristics: Full Length Transmembrane Proteins (synthetic Nanodisc)

Application Details

Application Notes:

• Applications for VLPs:
• ELISA
• SPR affinity analysis
• Phage display screening
• Immunization
• Cell based assays
• CAR-T cell screening
• Protein cystal structure analysis

Comment:

Synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Alternative Name: CXCR4 (CXCR4 Products)

Synonyms: CD184 Protein, D2S201E Protein, FB22 Protein, HM89 Protein, HSY3RR Protein, LAP3 Protein, LCR1 Protein, LESTR Protein, NPY3R Protein, NPYR Protein, NPYRL Protein, NPYY3R Protein, WHIM Protein, Cmkar4 Protein, PB-CKR Protein, PBSF/SDF-1 Protein, Sdf1r Protein, CXC-R4-B Protein, CXCR-4-B Protein, cd184 Protein, cxcr4 Protein, fb22 Protein, hm89 Protein, hsy3rr Protein, lap3 Protein, lcr1 Protein, lestr Protein, npy3r Protein, npyr Protein, npyrl Protein, npyy3r Protein, xcxcr4 Protein, CXC-R4 Protein, CXCR-4 Protein, d2s201e Protein, whim Protein, CXC-R4-A Protein, CXCR-4-A Protein, xCXCR4 Protein, CXCR4 Protein, cb403 Protein, zgc:109863 Protein, cb824 Protein, C-X-C motif chemokine receptor 4 Protein, chemokine (C-X-C motif) receptor 4 Protein, C-X-C motif chemokine receptor 4 S homeolog Protein, C-X-C chemokine receptor type 4 Protein, C-X-C motif chemokine receptor 4 L homeolog Protein, chemokine (C-X-C motif), receptor 4b Protein, chemokine (C-X-C motif) receptor 4a Protein, CXCR4 Protein, Cxcr4 Protein, cxcr4.S Protein, cxcr4 Protein, LOC100049444 Protein, cxcr4.L Protein, cxcr4b Protein, cxcr4a Protein

Background: CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS
Description: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Molecular Weight: The human full length CXCR4 protein has a MW of 39.6 kDa

UniProt: P61073

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events