CXCR4 Protein (AA 1-38) (His tag)

Catalog No. ABIN7504970

Product Details

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Protein Type: Recombinant

Protein Characteristics: AA 1-38

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CXCR4 protein is labelled with His tag.

Sequence: Met1-Lys38

Characteristics: A DNA sequence encoding the human CXCR4 (C28A) (1M-38K) was expressed with a GST tag at the N-terminus.

Purity: >95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Alternative Name: CXCR4 (CXCR4 Products)

Synonyms: CD184 Protein, D2S201E Protein, FB22 Protein, HM89 Protein, HSY3RR Protein, LAP3 Protein, LCR1 Protein, LESTR Protein, NPY3R Protein, NPYR Protein, NPYRL Protein, NPYY3R Protein, WHIM Protein, Cmkar4 Protein, PB-CKR Protein, PBSF/SDF-1 Protein, Sdf1r Protein, CXC-R4-B Protein, CXCR-4-B Protein, cd184 Protein, cxcr4 Protein, fb22 Protein, hm89 Protein, hsy3rr Protein, lap3 Protein, lcr1 Protein, lestr Protein, npy3r Protein, npyr Protein, npyrl Protein, npyy3r Protein, xcxcr4 Protein, CXC-R4 Protein, CXCR-4 Protein, d2s201e Protein, whim Protein, CXC-R4-A Protein, CXCR-4-A Protein, xCXCR4 Protein, CXCR4 Protein, cb403 Protein, zgc:109863 Protein, cb824 Protein, C-X-C motif chemokine receptor 4 Protein, chemokine (C-X-C motif) receptor 4 Protein, C-X-C motif chemokine receptor 4 S homeolog Protein, C-X-C chemokine receptor type 4 Protein, C-X-C motif chemokine receptor 4 L homeolog Protein, chemokine (C-X-C motif), receptor 4b Protein, chemokine (C-X-C motif) receptor 4a Protein, CXCR4 Protein, Cxcr4 Protein, cxcr4.S Protein, cxcr4 Protein, LOC100049444 Protein, cxcr4.L Protein, cxcr4b Protein, cxcr4a Protein

Background:

Background: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin, leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.

Synonym: C-X-C chemokine receptor type 4, CD184, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, NPYR, SDF 1 receptor, WHIM

Molecular Weight: 31.2 kDa

UniProt: P61073

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events