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Cryptochrome 1 (Photolyase-Like) Proteins (CRY1)

CRY1 encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. Additionally we are shipping CRY1 Antibodies (75) and CRY1 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CRY1 1407 Q16526
CRY1 12952 P97784
CRY1 299691 Q32Q86
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Top CRY1 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

CRY1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

Top referenced CRY1 Proteins

  1. Human CRY1 Protein expressed in Wheat germ - ABIN1350417 : Santagata, Maire, Idbaih, Geffers, Correll, Holton, Quackenbush, Ligon: CRX is a diagnostic marker of retinal and pineal lineage tumors. in PLoS ONE 2009 (PubMed)

More Proteins for Cryptochrome 1 (Photolyase-Like) (CRY1) Interaction Partners

Xenopus laevis Cryptochrome 1 (Photolyase-Like) (CRY1) interaction partners

  1. CRYs' C termini are essential for nuclear localization but not necessary for the suppression of CLOCK/BMAL1 (show ARNTL Proteins) activation

  2. we investigated the structure/function relationships of Xenopus laevis CRY1 (xCRY1) and xCRY2 (show CRY2 Proteins) in cultured cells

Rabbit Cryptochrome 1 (Photolyase-Like) (CRY1) interaction partners

  1. Cry1 is expressed in the olfactory bulb of newborn and juvenile rabbits.

Human Cryptochrome 1 (Photolyase-Like) (CRY1) interaction partners

  1. Altered CRY1 and CRY2 (show CRY2 Proteins) expression patterns and the interplay with the genetic landscape in colon cancer cells may underlie phenotypic divergence.

  2. possible circadian rhythm in full-term placental expression

  3. Given the distinct characteristics of the C-terminal tails of the CRY1 and CRY2 (show CRY2 Proteins) proteins, our study addresses a long-standing hypothesis that the ratio of these two CRY (show CRY2 Proteins) molecules affects the clock period.

  4. Overexpression of CRY1 protects against the development of atherosclerosis via the TLR/NFkappaB pathway

  5. Collectively, these data show that KPNB1 (show KPNB1 Proteins) is required for timely nuclear import of PER/CRY (show CRY2 Proteins) in the negative feedback regulation of the circadian clock.

  6. these observations suggest a biologically plausible season-dependent association between SNPs at CRY1, CRY2 and MTNR1B and glucose homeostasis.

  7. CRY1 and CRY2 (show CRY2 Proteins) variants showed nominal association with the metabolic syndrome components, hypertension and triglyceride levels.

  8. In men undergoing acute total sleep deprivation, there was increased methylation in the promoter of CRY1 in adipose tissue compared with controls. Also decreased gene expression in skeletal muscle.

  9. SNPs in CRY1 were significantly associated with overall survival in Chinese hepatocellular carcinoma patients.

  10. Study reveals an interaction between a CRY1 variant and carbohydrate intake for glucose metabolism.

Mouse (Murine) Cryptochrome 1 (Photolyase-Like) (CRY1) interaction partners

  1. Cryptochrome 1 in retinal cone photoreceptors suggests a novel functional role in mammals.

  2. polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 (show PER2 Proteins) and CRY1

  3. Data show that cryptochrome Cry1 and Cry2 (show CRY2 Proteins) expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP (show AVP Proteins)) receptor signaling is required to impose circuit-level circadian function.

  4. Overexpression of CRY1 protects against the development of atherosclerosis via the TLR/NFkappaB pathway

  5. uncovered a novel biological role for CUL4A (show CUL4A Proteins)-DDB1 (show DDB1 Proteins)-CDT2 E3 ligase that regulates molecular circadian behaviors via promoting ubiquitination-dependent degradation of CRY1

  6. Data suggest that cryptochromes (Cry1 and Cry2 (show CRY2 Proteins)) mediate periodic binding of Ck2b (show CSNK2B Proteins) (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like (show ARNTL Proteins) protein) and thus inhibit Bmal1 (show ARNTL Proteins)-Ser90 phosphorylation by Ck2a (show CSNK2A1 Proteins) (casein kinase 2alpha).

  7. demonstrate that genotoxic stress stimulates Cry1 phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp (show USP7 Proteins), a.k.a Usp7 (show USP7 Proteins)), stabilizing Cry1 and shifting circadian clock time

  8. Cry1/Cry2-deficient mice had significantly lower N6- methyladenosine methylation of RNA and lost the circadian rhythm of N6-methyladenosine levels in RNA.

  9. these results suggested that the overexpression of CRY1 inhibited sleep deprivation-induced vascular inflammation that might be associated with NF-kappaB (show NFKB1 Proteins) and cAMP/PKA pathways.

  10. These results suggest that CRY1 fulfills its role as an essential circadian repressor by sequestering the C-terminal transactivation domain of BMAL1 (show ARNTL Proteins) from coactivators.

Arabidopsis thaliana Cryptochrome 1 (Photolyase-Like) (CRY1) interaction partners

  1. These data illustrate that in vivo modulation by metabolites in the cellular environment may play an important role in cryptochrome signaling.

  2. For growth under a canopy, where blue light is diminished, CRY1 and CRY2 perceive this change and respond by directly contacting two bHLH transcription factors, PIF4 and PIF5.

  3. CRY1 represses auxin biosynthesis in response to elevated temperature through PIF4.

  4. CRY1 inhibits hypocotyl elongation in blue light through CNT1-mediated repression of the auxin/BR/GAresponsive gene expression.

  5. Reactive oxygen species formation results from cry1 activation and induces cell death in insect cell cultures.

  6. The study shows that ATP binding and aspartate protonation enhance photoinduced electron transfer in plant CRY1.

  7. photoreduction-deficient Trp (show TBPL1 Proteins)-triad mutations of CRY1 remained physiologically and biochemically active in Arabidopsis plants.

  8. Based on the loss of degradation of cry2 (show CRY2 Proteins) after prolonged darkness and loss of reversibility of photoactivated cry1 by a pulse of green light, we estimate the in vivo half-lives of the signaling states of cry1 and cry2 (show CRY2 Proteins) to be in the range of 5 and 16 min.

  9. Data indicate that the green light (GL) opposition of red light (RL) responses persists in phyA, phyB, cry1cry2 and phot2 mutants, and the response requires phot1 and NPH3.

  10. Perception of light by phyA, cry1 or phyB activates ROC1; this in turn reduces the intensity of brassinosteroid signalling and fine-tunes seedling de-etiolation.

CRY1 Protein Profile

Protein Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness.

Gene names and symbols associated with CRY1

  • cryptochrome 1 (photolyase-like) (cry1-A)
  • cryptochrome 1 (photolyase-like) (CRY1)
  • cryptochrome 1 (photolyase-like) (cry1)
  • cryptochrome 1 (CRY1)
  • LOC100384475 (siu50817b)
  • cryptochrome 1 (cry1)
  • cryptochrome 1 (photolyase-like) (LOC100223409)
  • cryptochrome 1 (photolyase-like) (LOC100347047)
  • cryptochrome 1 (photolyase-like) (Cry1)
  • cryptochrome-1 (CRY1)
  • ATCRY1 protein
  • AU020726 protein
  • AU021000 protein
  • BLU1 protein
  • CRY1 protein
  • cry1-A protein
  • cry2 protein
  • cryptochrome 1 protein
  • HY4 protein
  • OOP2 protein
  • OUT OF PHASE 2 protein
  • Phll1 protein
  • T3H13.14 protein
  • T3H13_14 protein
  • xCRY1 protein

Protein level used designations for CRY1

cryptochrome 1 (photolyase-like) , cryptochrome 2 (photolyase-like) , cryptochrome 1 , cryptochrome-1-like , cryptochrome-1

394398 Xenopus laevis
452205 Pan troglodytes
550065 Xenopus (Silurana) tropicalis
100008577 Meleagris gallopavo
100034165 Equus caballus
100384475 Zea mays
100500923 Bombyx mori
100223409 Taeniopygia guttata
100347047 Oryctolagus cuniculus
100408307 Callithrix jacchus
100431934 Pongo abelii
100484388 Ailuropoda melanoleuca
100582392 Nomascus leucogenys
1407 Homo sapiens
12952 Mus musculus
299691 Rattus norvegicus
100714070 Cavia porcellus
100520380 Sus scrofa
374093 Gallus gallus
474528 Canis lupus familiaris
535947 Bos taurus
443263 Ovis aries
826470 Arabidopsis thaliana
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