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The protein encoded by DUOX2 is a glycoprotein and a member of the NADPH oxidase family. Additionally we are shipping DUOX2 Kits (10) and DUOX2 Proteins (4) and many more products for this protein.
Showing 10 out of 37 products:
Dog (Canine) Polyclonal DUOX2 Primary Antibody for ICC, IF - ABIN258884
Morand, Chaaraoui, Kaniewski, Dème, Ohayon, Noel-Hudson, Virion, Dupuy: Effect of iodide on nicotinamide adenine dinucleotide phosphate oxidase activity and Duox2 protein expression in isolated porcine thyroid follicles. in Endocrinology 2003
Show all 4 references for ABIN258884
Human Polyclonal DUOX2 Primary Antibody for EIA, FACS - ABIN951993
Salmeen, Park, Meyer: The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway. in Oncogene 2010
Show all 2 references for ABIN951993
study expanded the mutational spectrum of the DUOX2 and thyroglobulin (show TG Antibodies) genes and provided the best estimation of the DUOX2 mutation rate (29%) for congenital hypothyroidism/subclinical congenital hypothyroidism patients in Guangxi Zhuang Autonomous Region of China
Seven different recurrent mutations [p.G488R (n=13), p.A649E (n=3), p.R885Q (n=3), p.I1080T (n=2), and p.A1206T (n=2) in DUOX2; p.Y138X (n=9) in DUOXA2 (show DUOXA2 Antibodies)) were identified as the mutations underlying congenital hypothyroidism.
Transient congenital hypothyroidism is caused by compound heterozygous mutations affecting the NADPH-oxidase (show NOX1 Antibodies) domain of DUOX2.
the house dust mite-dependent TLR2 (show TLR2 Antibodies)-Duox2 signalling axis promotes NF-kappaB (show NFKB1 Antibodies) activation, which induces IL-8 (show IL8 Antibodies) and CCL20 (show CCL20 Antibodies) production and mediates epidermal keratinocyte inflammation
Results identified 2 mutations in DUOX2 gene from patient with congenital hypothyroidism and report new cryptic splicing sites in the intron 17 and exon 18.
Decreased Panx1 (show PANX1 Antibodies) function is a response to cell acidification mediated by IFN-gamma-induced (show SAMHD1 Antibodies) up-regulation of Duox2.
inactivating mutations in the DUOXA2 (show DUOXA2 Antibodies) (p.Y246X) and DUOX2 (p.R885Q) genes were identified in a set of dizygotic twins with congenital hypothyroidism
Prevalence of DUOX2 pathogenic variants is 29% among patients with congenital hypothyroidism in Guangxi, China. Monoallelic and biallelic DUOX2 variants are associated with transient, while triallelic variants are associated with permanent disease.
The prognosis of Japanese patients with DUOX2 defects was usually transient Congenital hypothyroidism. Delayed improvement of thyroglobulin (show TG Antibodies) indicates that these patients have subclinical hypothyroidism.
Data indicate dual oxidase 2 protein (DUOX2) mutation-carrying pedigree presenting pseudodominant inheritance of nonautoimmune hypothyroidism.
the dual oxidase 2 N-terminal region is targeted to the plasma membrane
DUOX2 (show DUOX1 Antibodies) regulates interactions between the intestinal microbiota and the mucosa to maintain immune homeostasis in mice.
these data indicate that the gut (show GUSB Antibodies) microbiota uses two distinct signaling pathways to induce Duox2 (show DUOX1 Antibodies) expression in the ileum and colon epithelium.
Data suggest that proteinase-activated receptor 2 (show F2RL1 Antibodies) activation leads to up-regulation of the dual oxidase-2 (show DUOX1 Antibodies)/reactive oxygen species pathway in airway epithelial cells (AECs).
DUOX2 (show DUOX1 Antibodies)-generated ROS (show ROS1 Antibodies) induce AEC death.
a spontaneously generated valine 674-to-glycine mutation of murine Duox2 (show DUOX1 Antibodies) results in a translocation defect and complete loss of function that explains the severe congenital hypothyroid phenotype of the thyd/thyd mouse strain
DUOX2 (show DUOX1 Antibodies) plays pivotal roles in TLR5 (show TLR5 Antibodies)-dependent inflammatory response of nasal airway epithelium.
DUOX2 (show DUOX1 Antibodies) and NOD2 (show NOD2 Antibodies) cooperatively facilitate antibacterial action.
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.
dual oxidase 2
, dual oxidase 2-like
, NADH/NADPH thyroid oxidase p138-tox
, NADPH oxidase/peroxidase DUOX2
, NADPH thyroid oxidase 2
, dual oxidase-like domains 2
, flavoprotein NADPH oxidase
, large NOX 2
, long NOX 2
, nicotinamide adenine dinucleotide phosphate oxidase
, p138 thyroid oxidase
, thyroid oxidase 2
, NADH/NADPH thyroid oxidase THOX2