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The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Proteins (7) and Dynamin 1-Like Kits (4) and many more products for this protein.
Showing 10 out of 126 products:
Fish Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258397
Manczak, Calkins, Reddy: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. in Human molecular genetics 2011
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Human Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258391
Cheng, Guo, Copps, Dong, Kollipara, Rodgers, Depinho, Puigserver, White: Foxo1 integrates insulin signaling with mitochondrial function in the liver. in Nature medicine 2009
Show all 14 references for 258391
Fruit Fly (Drosophila melanogaster) Polyclonal DNM1L Primary Antibody for EIA, WB - ABIN492938
Madhavapeddi, Ballou, Marsh: Pre-steady-state kinetic studies on the Glu171Gln active site mutant of adenosylcobalamin-dependent glutamate mutase. in Biochemistry 2002
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Human Monoclonal DNM1L Primary Antibody for IHC (p), ELISA - ABIN564347
Figueroa-Romero, Iñiguez-Lluhí, Stadler, Chang, Arnoult, Keller, Hong, Blackstone, Feldman: SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
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Human Monoclonal DNM1L Primary Antibody for ICC, FACS - ABIN1724907
Thomas, Jacobson: Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. in PLoS ONE 2012
Show all 2 references for 1724907
Human Monoclonal DNM1L Primary Antibody for IHC, ELISA - ABIN1724863
Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. in Circulation research 2012
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Dog (Canine) Monoclonal DNM1L Primary Antibody for IF, WB - ABIN968652
Deyo, Chiao, Tainsky: drp, a novel protein expressed at high cell density but not during growth arrest. in DNA and cell biology 1998
The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Antibodies)- and dynamin (show DNM1 Antibodies)-dependent pathway.
The authors determine that Dengue virus nonstructural protein (NS)4B, a promising drug target with unknown function, associates with mitochondrial proteins, including Drp1 (show CRMP1 Antibodies), and alters mitochondria morphology to promote infection.
Depletion of septin 2 (show SEPT2 Antibodies) reduces Drp1 (show CRMP1 Antibodies) recruitment to mitochondria and results in hyperfused mitochondria and delayed FCCP-induced fission.
Missense variants in the middle domain of DNM1L is associated with infantile encephalopathy.
Gene (show CRMP1 Antibodies)tic silencing of Drp1 inc (show INS Antibodies)reases mitochondrial proton leak in MIN6 cells. Drp1 does not control insulin secretion via its effect on proton leak but instead via modulation of glucose-fueled respiration.
DNM1L missense mutation identified in a patient with developmental delay, refractory epilepsy and prolonged survival. Patient fibroblasts showed striking hyperfusion of the mitochondrial network. Bioenergetic studies in patient fibroblasts showed no significant differences versus controls.
Disruption of Drp1 (show CRMP1 Antibodies) and subsequent mitochondrial fragmentation events prevents impaired vascular dilation, restores mitochondrial phenotype, and implicates mitochondrial fission as a primary mediator of endothelial dysfunction
MiD49 (show SMCR7 Antibodies) and MiD51 (show SMCR7L Antibodies) recruit inactive forms of Drp1 (show CRMP1 Antibodies) in mitochondrial fission. [review]
FUNDC1 (show FUNDC1 Antibodies) integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 (show CRMP1 Antibodies) and calnexin (show CANX Antibodies) under hypoxic conditions in mammalian cells.
This study reveals an essential role of SUMOylated FADD (show FADD Antibodies) in Drp1 (show CRMP1 Antibodies)- and caspase-10 (show CASP10 Antibodies)-dependent necrosis.
Sustained phosphorylation of Akt (show AKT1 Antibodies) by Abeta (show APP Antibodies) directly activates Drp1 (show CRMP1 Antibodies) and inhibits autophagy through the mTOR (show FRAP1 Antibodies) pathway. Together, these changes elicit abundant mitochondrial fragmentation resulting in ROS (show ROS1 Antibodies)-mediated neuronal apoptosis.
Loss of Rip3 (show MPRIP Antibodies) significantly delays the degeneration of Drp1 (show CRMP1 Antibodies)-KO Purkinje neurons. Rip3 (show MPRIP Antibodies) loss also helps Drp1 (show CRMP1 Antibodies)-KO Purkinje cells maintain the elongated morphology of the mitochondrial tubules.
Drp1 (show CRMP1 Antibodies) does not control insulin (show INS Antibodies) secretion via its effect on proton leak but instead via modulation of glucose-fueled respiration.
These results suggest that neuropathology and combined cognitive decline can be attributed to hyperactivation of Drp1 (show CRMP1 Antibodies) in the pathogenesis of AD. Therefore, inhibitors of excessive mitochondrial fission, such as Drp1 (show CRMP1 Antibodies) inhibitors, may be a new strategy for AD.
MiD51 (show SMCR7L Antibodies) can suppress Mff (show MFF Antibodies)-dependent enhancement of Drp1 (show CRMP1 Antibodies) GTPase (show RACGAP1 Antibodies) activity.
These findings may have implications for the development of Drp1 (show CRMP1 Antibodies) based therapeutics for Alzheimer's disease patients.
these data unmasked a role for mitochondrial fission in leptin (show LEP Antibodies) sensitivity and glucose sensing of POMC (show POMC Antibodies) neurons.
Our results provide a molecular explanation for the contribution of Drp1 (show CRMP1 Antibodies) to the pathogenesis of sporadic Parkinson's disease (PD). These findings indicate that the SNO-Parkin (show PARK2 Antibodies) pathway may be a novel therapeutic target to treat PD
The data of this study demonstrated that dynamin 1 (show DNM1 Antibodies) is required for the formation, functional maturation, and subsequent survival of the calyx of Held.
sustained phosphorylation of Akt (show AKT1 Antibodies) by Abeta (show APP Antibodies) directly activates Drp1 (show CRMP1 Antibodies) and inhibits autophagy through the mTOR (show FRAP1 Antibodies) pathway. Together, these changes elicit abundant mitochondrial fragmentation resulting in ROS (show ROS1 Antibodies)-mediated neuronal apoptosis.
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.
, dynamin-1-like protein
, Dynamin-1-like protein
, dynamin-1-like protein-like
, dynamin related protein 1
, dynamin-like protein
, smooth muscle cell associated protein-3
, smooth muscle cell-associated protein 3
, Dnm1p/Vps1p-like protein
, dynamin family member proline-rich carboxyl-terminal domain less
, dynamin-like protein 4
, dynamin-like protein IV
, dynamin-related protein 1
, C-terminal region
, N-terminal region
, dynamin-like protein 1