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The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Proteins (7) and Dynamin 1-Like Kits (4) and many more products for this protein.
Showing 10 out of 123 products:
Fish Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258397
Manczak, Calkins, Reddy: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. in Human molecular genetics 2011
Show all 15 references for ABIN258397
Human Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258391
Cheng, Guo, Copps, Dong, Kollipara, Rodgers, Depinho, Puigserver, White: Foxo1 integrates insulin signaling with mitochondrial function in the liver. in Nature medicine 2009
Show all 14 references for ABIN258391
Human Monoclonal DNM1L Primary Antibody for IHC (p), ELISA - ABIN564347
Figueroa-Romero, Iñiguez-Lluhí, Stadler, Chang, Arnoult, Keller, Hong, Blackstone, Feldman: SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Show all 4 references for ABIN564347
Fruit Fly (Drosophila melanogaster) Polyclonal DNM1L Primary Antibody for EIA, WB - ABIN492938
Madhavapeddi, Ballou, Marsh: Pre-steady-state kinetic studies on the Glu171Gln active site mutant of adenosylcobalamin-dependent glutamate mutase. in Biochemistry 2002
Show all 4 references for ABIN492938
Human Monoclonal DNM1L Primary Antibody for ICC, FACS - ABIN1724907
Thomas, Jacobson: Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. in PLoS ONE 2012
Show all 2 references for ABIN1724907
Human Monoclonal DNM1L Primary Antibody for IHC, ELISA - ABIN1724863
Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. in Circulation research 2012
Show all 2 references for ABIN1724863
Dog (Canine) Monoclonal DNM1L Primary Antibody for IF, WB - ABIN968652
Deyo, Chiao, Tainsky: drp, a novel protein expressed at high cell density but not during growth arrest. in DNA and cell biology 1998
The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Antibodies)- and dynamin (show DNM1 Antibodies)-dependent pathway.
Drp1 (show CRMP1 Antibodies) was decreased on mitochondria during Dengue virus infection, as well as Drp1 (show CRMP1 Antibodies) phosphorylated on serine 616, which is important for mitochondrial fission.
These data suggest a model for ARSACS where neurons with reduced levels of sacsin are compromised in their ability to recruit or retain Drp1 (show CRMP1 Antibodies) at the mitochondrial membrane leading to a decline in mitochondrial health, potentially through impaired mitochondrial quality control.
Taken together, our data demonstrate that DRG2 (show DRG2 Antibodies) acts as a regulator of mitochondrial fission by controlling the expression of Drp1 (show CRMP1 Antibodies).
results lend further support to the notion that VPS35 (show vps35 Antibodies)-DLP1 interaction is key to the retromer-dependent recycling of mitochondrial DLP1 complex during mitochondrial fission and provide a novel therapeutic target to control excessive fission and associated mitochondrial deficits.
Mitochondrial morphology and cellular distribution are altered in SPG31 (show REEP1 Antibodies) patients and are linked to DRP1 (show CRMP1 Antibodies) hyperphosphorylation.
the mitochondrial division factor Dnm1 (show DNM1 Antibodies) in yeast or Drp1 (show CRMP1 Antibodies) in mammalian cells is dispensable for mitophagy.
Silencing Drp1 (show CRMP1 Antibodies) inhibits glioma cells proliferation and invasion by RHOA (show RHOA Antibodies)/ ROCK1 (show ROCK1 Antibodies) pathway.
that miR (show MLXIP Antibodies)-30a could inhibit TET1 (show TET1 Antibodies) expression through base pairing with complementary sites in the 3'untranslated region to regulate Drp-1 (show CRMP1 Antibodies) promoter hydroxymethylation.
Improper transcriptional (in)activation of mitofusin-1 (show MFN1 Antibodies) and dynamin-related protein 1 during early in vitro embryo development is associated with a decrease in mitochondrial membrane potential and with embryo fragmentation.
this study reveals coordinated increase of mitochondrial biogenesis and mitophagy in which Drp1 (show CRMP1 Antibodies) plays a central role regulating breast cancer cell metabolism and survival.
Thus, Drp1 (show CRMP1 Antibodies)-linked excessive mitochondrial fission contributed to VMC (show PLXNA3 Antibodies) and midivi1 may be a potential therapeutic approach.
In the absence of Drp1 (show CRMP1 Antibodies), connected mitochondria transiently depolarize. The transient depolarization is independent of calcium signaling and uncoupling protein 2 (show UCP2 Antibodies).
Parkin (show PARK2 Antibodies) protects against oxygen-glucose deprivation/reperfusion insult by promoting degradation of Drp1 (show CRMP1 Antibodies).
knockdown of Mfn2 (show MFN2 Antibodies) in adipo and osteogenesis and the overexpression of a dominant negative form of Drp1 (show CRMP1 Antibodies) during chondrogenesis resulted in a loss of differentiation ability
Drp1 (show CRMP1 Antibodies) regulates mitochondrial transport in growing dendrites of Purkinje cells and is required for dendritic arborization.
Mff (show MFF Antibodies) cannot bind to assembly-deficient mutants of Drp1 (show CRMP1 Antibodies), suggesting that Mff (show MFF Antibodies) selectively interacts with higher-order complexes of Drp1 (show CRMP1 Antibodies).
Loss of Drp1 (show CRMP1 Antibodies) compromises the intrinsic bioenergetic function of axonal mitochondria, thus revealing a mechanism by which disrupting mitochondrial dynamics can cause dysfunction of axons.
Drp1 (show CRMP1 Antibodies) is required for functionally active mitochondria, and supplementing with ATP can restore the defects induced by Drp1 (show CRMP1 Antibodies) suppression.
These findings strongly suggest that Drp1 (show CRMP1 Antibodies) plays an important role in determining the fate of cells after irradiation via the regulation of mitochondrial dynamics.
our in vivo observations clarify the role of mitochondrial fission in neurons, demonstrating that Drp1 (show CRMP1 Antibodies) ablation in adult forebrain neurons compromises critical neuronal functions without causing overt neurodegeneration.
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.
, dynamin-1-like protein
, Dynamin-1-like protein
, dynamin-1-like protein-like
, dynamin related protein 1
, dynamin-like protein
, smooth muscle cell associated protein-3
, smooth muscle cell-associated protein 3
, Dnm1p/Vps1p-like protein
, dynamin family member proline-rich carboxyl-terminal domain less
, dynamin-like protein 4
, dynamin-like protein IV
, dynamin-related protein 1
, C-terminal region
, N-terminal region
, dynamin-like protein 1