anti-Dynamin 1-Like (DNM1L) Antibodies

The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Proteins (7) and Dynamin 1-Like Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DNM1L 10059 O00429
DNM1L 74006 Q8K1M6
DNM1L 114114 O35303
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Top anti-Dynamin 1-Like Antibodies at antibodies-online.com

Showing 10 out of 127 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-DNM1L Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Hela cell lysate <b>Sample Type</b>: 2. mouse brain extracts (80ug)<br> <b>Primary Antibody Dilution:</b> 2ug/ml<br> <b>Secondary Antibody</b>: IRDye 800CW goat anti-rabbit from Li-COR Bioscience<br> <b>Secondary Antibody Dilution:</b> 1: 20,000<br> <b>Image Submitted by</b>: Yuzhi Chen<br> University of Arkansas for Medical Science 100 μL Log in to see 2 to 3 Days
$289.00
Details
Fish Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, SimWes, WB Staining of renal tubular epithelium and visceral epithelial cells of the glomerulus using ABIN258397 at 2.5ug/ml.  Human kidney cortex, 40X magnification. 0.1 mL Log in to see 7 to 9 Days
$473.81
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, SimWes, WB Staining of renal tubular epithelium and visceral epithelial cells of glomeruli using ABIN258391 at 2.5ug/ml.  Human kidney cortex, 40X magnification. Staining of DRP-1 in mouse embryonic fibroblast post-nuclear extracts using ABIN258391. Image courtesy of D. Chan California Institute of Technology. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Mouse Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$430.10
Details
Dog Mouse Un-conjugated IF, WB Western blot analysis of Drp1 on a HCT-8 cell lysate (Human colorectal adenocarcinoma, ATCC CCL-244). Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the mouse anti-Drp1 antibody. Immunofluorescence staining on A431 cells (Human epithelial carcinoma, ATCC CRL-1555). 150 μg Log in to see 6 to 8 Days
$278.97
Details
Human Mouse Un-conjugated ICC, FACS, ELISA, WB 100 μL Log in to see 2 to 3 Days
$430.10
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of specific cells using DRP1 Polyclonal Antibody. 100 μL Log in to see 16 Days
$175.80
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$175.80
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to DNM1L on formalin-fixed paraffin-embedded human leiomyosarcoma tissue. [antibody concentration 1 ug/ml] DNM1L monoclonal antibody (M01), clone 3B5 Western Blot analysis of DNM1L expression in K-562 . 100 μg Log in to see 11 to 12 Days
$430.00
Details

DNM1L Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Dynamin 1-Like Antibodies

  1. Fish Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258397 : Manczak, Calkins, Reddy: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. in Human molecular genetics 2011 (PubMed)
    Show all 16 Pubmed References

  2. Human Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258391 : Cheng, Guo, Copps, Dong, Kollipara, Rodgers, Depinho, Puigserver, White: Foxo1 integrates insulin signaling with mitochondrial function in the liver. in Nature medicine 2009 (PubMed)
    Show all 14 Pubmed References

  3. Mouse (Murine) Polyclonal DNM1L Primary Antibody for IHC - ABIN966011 : Honda, Hirose: Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis. in Biochemical and biophysical research communications 2003 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal DNM1L Primary Antibody for IHC (p), ELISA - ABIN564347 : Figueroa-Romero, Iñiguez-Lluhí, Stadler, Chang, Arnoult, Keller, Hong, Blackstone, Feldman: SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 (PubMed)
    Show all 4 Pubmed References

  5. Human Monoclonal DNM1L Primary Antibody for IHC, ELISA - ABIN1724863 : Thomas, Jacobson: Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. in PLoS ONE 2012 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal DNM1L Primary Antibody for ICC, FACS - ABIN1724907 : Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. in Circulation research 2012 (PubMed)
    Show all 2 Pubmed References

  7. Dog (Canine) Monoclonal DNM1L Primary Antibody for IF, WB - ABIN968652 : Deyo, Chiao, Tainsky: drp, a novel protein expressed at high cell density but not during growth arrest. in DNA and cell biology 1998 (PubMed)

  8. Cow (Bovine) Polyclonal DNM1L Primary Antibody for IHC, WB - ABIN2784887 : Su, Chiu, Hung, Hong: Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting. in Apoptosis : an international journal on programmed cell death 2014 (PubMed)

More Antibodies against Dynamin 1-Like Interaction Partners

Rabbit Dynamin 1-Like (DNM1L) interaction partners

  1. The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Antibodies)- and dynamin (show DNM1 Antibodies)-dependent pathway.

Human Dynamin 1-Like (DNM1L) interaction partners

  1. This report describes a patient with a DNM1L mutation and abnormalities in mitochondrial fission and function. The pathogenicity and the dominant nature of the novel p.G362S mutation are demonstrated by overexpression of the mutant gene.

  2. In contrast to the initial report of neonatal lethality resulting from DNM1L mutation and DRP1 (show CRMP1 Antibodies) dysfunction, our results show that milder DRP1 (show CRMP1 Antibodies) impairment is compatible with normal early development and subsequently results in a distinct set of neurological findings. In addition, we identify a common pathogenic mechanism whereby DNM1L mutations impair mitochondrial fission.

  3. These findings provide new insights into MCL-1 (show MCL1 Antibodies) ligands, and the interplay between DRP-1 (show CRMP1 Antibodies) and the anti-apoptotic BCL-2 (show BCL2 Antibodies) family members in the regulation of apoptosis

  4. High drp1 (show CRMP1 Antibodies) expression is associated with cisplatin-induced apoptosis of renal tubular epithelial cells.

  5. This study demonstrated that Mutations in DNM1L, as in OPA1 (show OPA1 Antibodies), result indominant optic atrophy despite opposite effectson mitochondrial fusion and fission.

  6. Reinitiation complexes involving initiation factors eIF2D (show EIF2D Antibodies), MCT-1 (show CMA1 Antibodies), and DENR (show DENR Antibodies) controls the translation of a large fraction of mammalian cellular mRNAs.

  7. Modulation of mitochondrial fission by increased levels of pDrp1 S616.

  8. This is the first study to identify an association between SIRT4 expression and decreased mitochondrial fission, which was driven by Drp1. SIRT4 inhibited Drp1 phosphorylation and weakened Drp1 recruitment to the mitochondrial membrane via an interaction with Fis-1.

  9. the mitochondrial morphology of T-cell acute lymphoblastic leukemia cells were altered from elongation to fragmentation because of the extracellular signal-regulated kinase activation-mediated phosphorylation of the pro-fission factor, dynamin-related protein 1 (Drp1), at residue S616.

  10. DNM1L was found to be involved in the regulation of collagen secretion and cardiovascular calcification.

Mouse (Murine) Dynamin 1-Like (DNM1L) interaction partners

  1. Pharmacological inhibition of Drp1 (show CRMP1 Antibodies) prevents mitochondrial fission and reduces myocardial ischemia-reperfusion injury in diabetic mice.

  2. Report a novel non-canonical function of the fission protein, DRP1 (show CRMP1 Antibodies) in maintaining or positively stimulating mitochondrial respiration, bioenergetics and ROS (show ROS1 Antibodies) signalling in adult cardiomyocyte, which is likely independent of morphological changes.

  3. Deletion of Sirt5 (show SIRT5 Antibodies) in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 (show CRMP1 Antibodies) and to mitochondrial fragmentation.

  4. Podocyte apoptosis induced by hyperglycemia can be reversed by polydatin through suppressing Drp1 (show CRMP1 Antibodies) expression.

  5. Heat acclimation and heat shock cause changes in mitochondrial morphology of muscle cells by acting on Drp1 (show CRMP1 Antibodies), which results in favoring mitochondrial fusion and fission, respectively.

  6. findings provide new insights into the role of the Drp1 (show CRMP1 Antibodies)-dependent mitochondrial pathway in the osteogenic dysfunction during inflammation, indicating that this pathway may be a target for the development of new therapeutic approaches for the prevention and treatment of inflammation-induced bone destruction

  7. Drp1 (show CRMP1 Antibodies) binds a mitochondrial enzyme that produces phosphatidic acid, MitoPLD (show PLD6 Antibodies), and regulates mitochondrial division.

  8. Loss of Rip3 (show MPRIP Antibodies) significantly delays the degeneration of Drp1 (show CRMP1 Antibodies)-KO Purkinje neurons. Rip3 (show MPRIP Antibodies) loss also helps Drp1 (show CRMP1 Antibodies)-KO Purkinje cells maintain the elongated morphology of the mitochondrial tubules.

  9. Drp1 (show CRMP1 Antibodies) does not control insulin (show INS Antibodies) secretion via its effect on proton leak but instead via modulation of glucose-fueled respiration.

  10. These results suggest that neuropathology and combined cognitive decline can be attributed to hyperactivation of Drp1 (show CRMP1 Antibodies) in the pathogenesis of AD. Therefore, inhibitors of excessive mitochondrial fission, such as Drp1 (show CRMP1 Antibodies) inhibitors, may be a new strategy for AD.

Dynamin 1-Like (DNM1L) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.

Gene names and symbols associated with anti-Dynamin 1-Like (DNM1L) Antibodies

  • dynamin 1 like (DNM1L) antibody
  • dynamin 1-like (Dnm1l) antibody
  • dynamin 1-like L homeolog (dnm1l.L) antibody
  • dynamin 1-like (dnm1l) antibody
  • dynamin-1-like (LOC100369408) antibody
  • dynamin 1 like (dnm1l) antibody
  • dynamin-1-like protein (LOC411472) antibody
  • dynamin-like protein (PF10_0368) antibody
  • dynamin-like protein (dyn1) antibody
  • dynamin-like protein (cgd1_580) antibody
  • dynamin-like protein (EHI_052740) antibody
  • dynamin-like protein (PVX_092875) antibody
  • dynamin-like protein (BBOV_II002980) antibody
  • dynamin 1 like (Dnm1l) antibody
  • Dynamin related protein 1 (Drp1) antibody
  • 18.m06247 antibody
  • 6330417M19Rik antibody
  • AI450666 antibody
  • CG3210 antibody
  • Dlp1 antibody
  • Dmel\CG3210 antibody
  • Dnm1/Drp1 antibody
  • DNM1L antibody
  • Dnml1 antibody
  • Dnmlp1 antibody
  • Drp antibody
  • drp-1 antibody
  • drp1 antibody
  • DVLP antibody
  • DYMPLE antibody
  • EMPF antibody
  • frat antibody
  • HDYNIV antibody
  • l(2)22Fc antibody
  • l(2)22Fd antibody
  • l(2)ND2 antibody
  • l(2)ND3 antibody
  • MGC53850 antibody
  • python antibody
  • zgc:66163 antibody

Protein level used designations for anti-Dynamin 1-Like (DNM1L) Antibodies

Dnm1p/Vps1p-like protein , dynamin family member proline-rich carboxyl-terminal domain less , dynamin-1-like protein , dynamin-like protein 4 , dynamin-like protein IV , dynamin-related protein 1 , dymple , C-terminal region , N-terminal region , dynamin-like protein 1 , dynamin 1-like , Dynamin-1-like protein , dynamin-1-like protein-like , dynamin related protein 1 , dynamin-like protein , CG3210 gene product from transcript CG3210-RB , CG3210-PA , CG3210-PB , Drp1-PA , Drp1-PB , dynamin related protein-1 , dynamin-2 , dynamin-related protein , dynaminrelated protein 1 , fratboy , lethal(2)22Fc , lethal(2)22Fd , near dpp complementation group 2 , near dpp complementation group 3 , noodle

GENE ID SPECIES
10059 Homo sapiens
74006 Mus musculus
114114 Rattus norvegicus
379875 Xenopus laevis
393896 Danio rerio
418132 Gallus gallus
465266 Pan troglodytes
477649 Canis lupus familiaris
540892 Bos taurus
695388 Macaca mulatta
100229161 Taeniopygia guttata
100338814 Oryctolagus cuniculus
100369408 Saccoglossus kowalevskii
100380278 Salmo salar
100474116 Ailuropoda melanoleuca
100560647 Anolis carolinensis
411472 Apis mellifera
810525 Plasmodium falciparum 3D7
811008 Plasmodium falciparum 3D7
3371500 Cryptosporidium parvum Iowa II
3405942 Entamoeba histolytica HM-1:IMSS
5474863 Plasmodium vivax Sal-1
5478050 Babesia bovis T2Bo
100728964 Cavia porcellus
33445 Drosophila melanogaster
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