Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Proteins (7) and Dynamin 1-Like Kits (6) and many more products for this protein.
Showing 10 out of 127 products:
Fish Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258397
Manczak, Calkins, Reddy: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. in Human molecular genetics 2011
Show all 16 Pubmed References
Human Polyclonal DNM1L Primary Antibody for ICC, IF - ABIN258391
Cheng, Guo, Copps, Dong, Kollipara, Rodgers, Depinho, Puigserver, White: Foxo1 integrates insulin signaling with mitochondrial function in the liver. in Nature medicine 2009
Show all 14 Pubmed References
Mouse (Murine) Polyclonal DNM1L Primary Antibody for IHC - ABIN966011
Honda, Hirose: Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis. in Biochemical and biophysical research communications 2003
Show all 5 Pubmed References
Human Monoclonal DNM1L Primary Antibody for IHC (p), ELISA - ABIN564347
Figueroa-Romero, Iñiguez-Lluhí, Stadler, Chang, Arnoult, Keller, Hong, Blackstone, Feldman: SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Show all 4 Pubmed References
Human Monoclonal DNM1L Primary Antibody for IHC, ELISA - ABIN1724863
Thomas, Jacobson: Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. in PLoS ONE 2012
Show all 2 Pubmed References
Human Monoclonal DNM1L Primary Antibody for ICC, FACS - ABIN1724907
Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. in Circulation research 2012
Show all 2 Pubmed References
Dog (Canine) Monoclonal DNM1L Primary Antibody for IF, WB - ABIN968652
Deyo, Chiao, Tainsky: drp, a novel protein expressed at high cell density but not during growth arrest. in DNA and cell biology 1998
Cow (Bovine) Polyclonal DNM1L Primary Antibody for IHC, WB - ABIN2784887
Su, Chiu, Hung, Hong: Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting. in Apoptosis : an international journal on programmed cell death 2014
The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Antibodies)- and dynamin (show DNM1 Antibodies)-dependent pathway.
This report describes a patient with a DNM1L mutation and abnormalities in mitochondrial fission and function. The pathogenicity and the dominant nature of the novel p.G362S mutation are demonstrated by overexpression of the mutant gene.
In contrast to the initial report of neonatal lethality resulting from DNM1L mutation and DRP1 (show CRMP1 Antibodies) dysfunction, our results show that milder DRP1 (show CRMP1 Antibodies) impairment is compatible with normal early development and subsequently results in a distinct set of neurological findings. In addition, we identify a common pathogenic mechanism whereby DNM1L mutations impair mitochondrial fission.
These findings provide new insights into MCL-1 (show MCL1 Antibodies) ligands, and the interplay between DRP-1 (show CRMP1 Antibodies) and the anti-apoptotic BCL-2 (show BCL2 Antibodies) family members in the regulation of apoptosis
High drp1 (show CRMP1 Antibodies) expression is associated with cisplatin-induced apoptosis of renal tubular epithelial cells.
This study demonstrated that Mutations in DNM1L, as in OPA1 (show OPA1 Antibodies), result indominant optic atrophy despite opposite effectson mitochondrial fusion and fission.
Reinitiation complexes involving initiation factors eIF2D (show EIF2D Antibodies), MCT-1 (show CMA1 Antibodies), and DENR (show DENR Antibodies) controls the translation of a large fraction of mammalian cellular mRNAs.
Modulation of mitochondrial fission by increased levels of pDrp1 S616.
This is the first study to identify an association between SIRT4 expression and decreased mitochondrial fission, which was driven by Drp1. SIRT4 inhibited Drp1 phosphorylation and weakened Drp1 recruitment to the mitochondrial membrane via an interaction with Fis-1.
the mitochondrial morphology of T-cell acute lymphoblastic leukemia cells were altered from elongation to fragmentation because of the extracellular signal-regulated kinase activation-mediated phosphorylation of the pro-fission factor, dynamin-related protein 1 (Drp1), at residue S616.
DNM1L was found to be involved in the regulation of collagen secretion and cardiovascular calcification.
Pharmacological inhibition of Drp1 (show CRMP1 Antibodies) prevents mitochondrial fission and reduces myocardial ischemia-reperfusion injury in diabetic mice.
Report a novel non-canonical function of the fission protein, DRP1 (show CRMP1 Antibodies) in maintaining or positively stimulating mitochondrial respiration, bioenergetics and ROS (show ROS1 Antibodies) signalling in adult cardiomyocyte, which is likely independent of morphological changes.
Deletion of Sirt5 (show SIRT5 Antibodies) in starved mouse embryonic fibroblasts increased levels of mitochondrial dynamics leading to mitochondrial accumulation of the pro-fission Drp1 (show CRMP1 Antibodies) and to mitochondrial fragmentation.
Podocyte apoptosis induced by hyperglycemia can be reversed by polydatin through suppressing Drp1 (show CRMP1 Antibodies) expression.
Heat acclimation and heat shock cause changes in mitochondrial morphology of muscle cells by acting on Drp1 (show CRMP1 Antibodies), which results in favoring mitochondrial fusion and fission, respectively.
findings provide new insights into the role of the Drp1 (show CRMP1 Antibodies)-dependent mitochondrial pathway in the osteogenic dysfunction during inflammation, indicating that this pathway may be a target for the development of new therapeutic approaches for the prevention and treatment of inflammation-induced bone destruction
Drp1 (show CRMP1 Antibodies) binds a mitochondrial enzyme that produces phosphatidic acid, MitoPLD (show PLD6 Antibodies), and regulates mitochondrial division.
Loss of Rip3 (show MPRIP Antibodies) significantly delays the degeneration of Drp1 (show CRMP1 Antibodies)-KO Purkinje neurons. Rip3 (show MPRIP Antibodies) loss also helps Drp1 (show CRMP1 Antibodies)-KO Purkinje cells maintain the elongated morphology of the mitochondrial tubules.
Drp1 (show CRMP1 Antibodies) does not control insulin (show INS Antibodies) secretion via its effect on proton leak but instead via modulation of glucose-fueled respiration.
These results suggest that neuropathology and combined cognitive decline can be attributed to hyperactivation of Drp1 (show CRMP1 Antibodies) in the pathogenesis of AD. Therefore, inhibitors of excessive mitochondrial fission, such as Drp1 (show CRMP1 Antibodies) inhibitors, may be a new strategy for AD.
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.
, dynamin family member proline-rich carboxyl-terminal domain less
, dynamin-1-like protein
, dynamin-like protein 4
, dynamin-like protein IV
, dynamin-related protein 1
, C-terminal region
, N-terminal region
, dynamin-like protein 1
, dynamin 1-like
, Dynamin-1-like protein
, dynamin-1-like protein-like
, dynamin related protein 1
, dynamin-like protein
, CG3210 gene product from transcript CG3210-RB
, dynamin related protein-1
, dynamin-related protein
, dynaminrelated protein 1
, near dpp complementation group 2
, near dpp complementation group 3