Dynamin 1-Like (DNM1L) (AA 69-213) antibody

Details for Product No. ABIN1724863
Antigen
Epitope
AA 69-213
41
17
8
7
4
4
4
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
150
104
94
7
4
3
3
2
2
2
1
1
1
1
1
1
1
1
Host
Mouse
129
25
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
8
7
7
7
6
6
6
4
3
3
2
2
2
2
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
93
54
52
31
25
22
11
7
5
3
1
1
Options
Immunogen Purified recombinant fragment of human DNM1L (AA 69-213) expressed in E. Coli.
Clone 4E11B11
Isotype IgG1
Purification Purified
Antigen
Alternative Name DNM1L (DNM1L Antibody Abstract)
Background The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated. , ,
Molecular Weight 81.9 kDa
Gene ID 10059
HGNC 10059
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Dynamin 1-Like (DNM1L) (AA 69-213) antibody (ABIN1724863) Immunohistochemical analysis of paraffin-embedded cerebellum tissues using DNM1L mous...
Image no. 2 for anti-Dynamin 1-Like (DNM1L) (AA 69-213) antibody (ABIN1724863) Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using DNM1L ...
Product cited in: Thomas, Jacobson: "Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model." in: PLoS ONE, Vol. 7, Issue 9, pp. e45319, 2012 (PubMed).

Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: "Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension." in: Circulation research, Vol. 110, Issue 11, pp. 1484-97, 2012 (PubMed).