Dynamin 1-Like Proteins (DNM1L)

The protein encoded by DNM1L is a member of the dynamin superfamily of GTPases. Additionally we are shipping Dynamin 1-Like Antibodies (127) and Dynamin 1-Like Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNM1L 8562 O43583
DNM1L 74006 Q8K1M6
DNM1L 114114 O35303
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Top Dynamin 1-Like Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Fruit Fly Un-conjugated   5 applications Log in to see 1 to 2 Days

DNM1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,

Top referenced Dynamin 1-Like Proteins

  1. Human DNM1L Protein expressed in Wheat germ - ABIN1351855 : Qi, Qvit, Su, Mochly-Rosen: A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. in Journal of cell science 2013 (PubMed)
    Show all 4 references for 1351855

  2. Human DNM1L Protein expressed in HEK-293 Cells - ABIN2719860 : Guo, Lu, Huang, Wu, Zhang, Yu, Zhang, Bao, He, Chen, Jia: Protective role of PGC-1α in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling. in PLoS ONE 2015 (PubMed)

More Proteins for Dynamin 1-Like (DNM1L) Interaction Partners

Rabbit Dynamin 1-Like (DNM1L) interaction partners

  1. The authors conclude that clathrin-independent compensatory endocytosis in umbrella cells is integrin regulated and occurs by a RhoA (show RHOA Proteins)- and dynamin (show DNM1 Proteins)-dependent pathway.

Human Dynamin 1-Like (DNM1L) interaction partners

  1. Modulation of mitochondrial fission by increased levels of pDrp1 S616.

  2. This is the first study to identify an association between SIRT4 expression and decreased mitochondrial fission, which was driven by Drp1. SIRT4 inhibited Drp1 phosphorylation and weakened Drp1 recruitment to the mitochondrial membrane via an interaction with Fis-1.

  3. the mitochondrial morphology of T-cell acute lymphoblastic leukemia cells were altered from elongation to fragmentation because of the extracellular signal-regulated kinase activation-mediated phosphorylation of the pro-fission factor, dynamin-related protein 1 (Drp1), at residue S616.

  4. DNM1L was found to be involved in the regulation of collagen secretion and cardiovascular calcification.

  5. The authors determine that Dengue virus nonstructural protein (NS)4B, a promising drug target with unknown function, associates with mitochondrial proteins, including Drp1, and alters mitochondria morphology to promote infection.

  6. Depletion of septin 2 reduces Drp1 recruitment to mitochondria and results in hyperfused mitochondria and delayed FCCP-induced fission.

  7. Missense variants in the middle domain of DNM1L is associated with infantile encephalopathy.

  8. Gene (show CRMP1 Proteins)tic silencing of Drp1 inc (show INS Proteins)reases mitochondrial proton leak in MIN6 cells. Drp1 does not control insulin secretion via its effect on proton leak but instead via modulation of glucose-fueled respiration.

  9. DNM1L missense mutation identified in a patient with developmental delay, refractory epilepsy and prolonged survival. Patient fibroblasts showed striking hyperfusion of the mitochondrial network. Bioenergetic studies in patient fibroblasts showed no significant differences versus controls.

  10. Disruption of Drp1 and subsequent mitochondrial fragmentation events prevents impaired vascular dilation, restores mitochondrial phenotype, and implicates mitochondrial fission as a primary mediator of endothelial dysfunction

Mouse (Murine) Dynamin 1-Like (DNM1L) interaction partners

  1. Podocyte apoptosis induced by hyperglycemia can be reversed by polydatin through suppressing Drp1 expression.

  2. Heat acclimation and heat shock cause changes in mitochondrial morphology of muscle cells by acting on Drp1, which results in favoring mitochondrial fusion and fission, respectively.

  3. findings provide new insights into the role of the Drp1-dependent mitochondrial pathway in the osteogenic dysfunction during inflammation, indicating that this pathway may be a target for the development of new therapeutic approaches for the prevention and treatment of inflammation-induced bone destruction

  4. Drp1 (show CRMP1 Proteins) binds a mitochondrial enzyme that produces phosphatidic acid, MitoPLD (show PLD6 Proteins), and regulates mitochondrial division.

  5. Loss of Rip3 significantly delays the degeneration of Drp1-KO Purkinje neurons. Rip3 loss also helps Drp1-KO Purkinje cells maintain the elongated morphology of the mitochondrial tubules.

  6. Drp1 (show CRMP1 Proteins) does not control insulin (show INS Proteins) secretion via its effect on proton leak but instead via modulation of glucose-fueled respiration.

  7. These results suggest that neuropathology and combined cognitive decline can be attributed to hyperactivation of Drp1 in the pathogenesis of AD. Therefore, inhibitors of excessive mitochondrial fission, such as Drp1 inhibitors, may be a new strategy for AD.

  8. MiD51 (show SMCR7L Proteins) can suppress Mff (show MFF Proteins)-dependent enhancement of Drp1 (show CRMP1 Proteins) GTPase (show RACGAP1 Proteins) activity.

  9. These findings may have implications for the development of Drp1 based therapeutics for Alzheimer's disease patients.

  10. these data unmasked a role for mitochondrial fission in leptin (show LEP Proteins) sensitivity and glucose sensing of POMC (show POMC Proteins) neurons.

Dynamin 1-Like (DNM1L) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.

Gene names and symbols associated with Dynamin 1-Like Proteins (DNM1L)

  • dynamin 1-like (dnm1l)
  • dynamin 1-like (DNM1L)
  • dynamin 1-like (LOC100229161)
  • dynamin 1-like (LOC100338814)
  • dynamin 1-like (LOC100369408)
  • dynamin related protein 1 (Drp1)
  • dynamin-like protein (PF10_0368)
  • dynamin-like protein (dyn1)
  • dynamin-like protein (cgd1_580)
  • dynamin-like protein (EHI_052740)
  • dynamin-like protein (PVX_092875)
  • dynamin-like protein (BBOV_II002980)
  • density-regulated protein (DENR)
  • dynamin 1-like (Dnm1l)
  • 18.m06247 protein
  • 6330417M19Rik protein
  • AI450666 protein
  • Dlp1 protein
  • DNM1L protein
  • Dnml1 protein
  • Dnmlp1 protein
  • DRP protein
  • Drp1 protein
  • DVLP protein
  • DYMPLE protein
  • EMPF protein
  • HDYNIV protein
  • MGC53850 protein
  • python protein
  • SMAP-3 protein
  • zgc:66163 protein

Protein level used designations for Dynamin 1-Like Proteins (DNM1L)

dynamin 1-like , dynamin-1-like protein , Dynamin-1-like protein , dynamin-1-like protein-like , dynamin related protein 1 , dynamin-like protein , smooth muscle cell associated protein-3 , smooth muscle cell-associated protein 3 , Dnm1p/Vps1p-like protein , dynamin family member proline-rich carboxyl-terminal domain less , dynamin-like protein 4 , dynamin-like protein IV , dynamin-related protein 1 , dymple , C-terminal region , N-terminal region , dynamin-like protein 1

379875 Xenopus laevis
393896 Danio rerio
418132 Gallus gallus
465266 Pan troglodytes
695388 Macaca mulatta
100229161 Taeniopygia guttata
100338814 Oryctolagus cuniculus
100369408 Saccoglossus kowalevskii
100380278 Salmo salar
100474116 Ailuropoda melanoleuca
100560647 Anolis carolinensis
411472 Apis mellifera
810525 Plasmodium falciparum 3D7
811008 Plasmodium falciparum 3D7
3371500 Cryptosporidium parvum Iowa II
3405942 Entamoeba histolytica HM-1:IMSS
5474863 Plasmodium vivax Sal-1
5478050 Babesia bovis T2Bo
8562 Homo sapiens
10059 Homo sapiens
74006 Mus musculus
114114 Rattus norvegicus
540892 Bos taurus
477649 Canis lupus familiaris
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