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Ezrin Proteins (EZR)

The cytoplasmic peripheral membrane protein encoded by EZR functions as a protein-tyrosine kinase substrate in microvilli. Additionally we are shipping Ezrin Antibodies (378) and Ezrin Kits (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EZR 7430 P15311
EZR 22350 P26040
EZR 54319 P31977
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Top Ezrin Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$2,150.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,681.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

EZR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced Ezrin Proteins

  1. Human EZR Protein expressed in Human - ABIN2720647 : Miyaji, Shahrizaila, Umapathi, Chan, Hirata, Yuki: Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies? in Human immunology 2015 (PubMed)
    Show all 2 references for ABIN2720647

More Proteins for Ezrin (EZR) Interaction Partners

Human Ezrin (EZR) interaction partners

  1. the distribution of NHERF1 (show SLC9A3R1 Proteins) in ovarian cancer and reveals a different regulation of NHERF1 (show SLC9A3R1 Proteins) and EZRIN expression in ovarian tumors which represents the complexity of the molecular changes of this disease

  2. Phosphorylation of ezrin together with its binding to phosphatidylinositol-4,5-bisphosphate tethers the F508del CFTR to the actin cytoskeleton, stabilizing it on the apical membrane and rescuing the sub-membrane compartmentalization of cAMP and activated PKA.

  3. Data show that gene silence of ezrin inhibits the proliferation and invasion of prostate cancer PC-3 (show PCSK1 Proteins) cells, meanwhile the level of E-cadherin (show CDH1 Proteins) is upregulated and N-cadherin (show CDH2 Proteins) is downregulated.

  4. Knockdown of ezrin in HUVECs significantly induced the morphogenetic changes and cytoskeletal reorganization of the transfected cells, and also reduced cell migration and angiogenesis capacity in vitro.

  5. High EZRIN expression is associated with prostate cancer.

  6. Elevated Ezrin expression is associated with a poor prognosis in a variety of solid tumors.

  7. These findings suggest that ezrin-EGFR (show EGFR Proteins) interaction augments oncogenic functions of EGFR (show EGFR Proteins) and that targeting ezrin may provide a potential novel approach to overcome erlotinib resistance in non-small cell lung cancer cells

  8. The value of ezrin expression as a prognostic biomarker is further consolidated in urothelial cancer.

  9. Suggest a role for ezrin in advanced glycation end product-induced podocyte damage.

  10. Phospho-Ezrin/Radixin/Moesin (ERM (show MSN Proteins)) inhibit cell adhesion, and therefore, dephosphorylation of ERM (show ETV5 Proteins) proteins is essential for cell adhesion.Phospho-ERM (show ETV5 Proteins) induce formation and/or maintenance of spherical cell shape.

Cow (Bovine) Ezrin (EZR) interaction partners

  1. Ezrin and CK18 (show KRT18 Proteins) are downregulated during implantation in cattle. The expression changes represent a temporal depolarization, which could be important for an establishment of bovine pregnancy.

  2. Ezrin-dependent, membrane-specific translocation and activation of calpain by VEGF (show VEGFA Proteins) precedes AMPK (show PRKAA1 Proteins) and AKT (show AKT1 Proteins)-dependent phosphorylation of eNOSs1179 and production of NO.

Mouse (Murine) Ezrin (EZR) interaction partners

  1. Augmented hypertension-induced glomerular capillary injury in mice lacking CLIC5 results from abrogation of Rac1-dependent Pak and ezrin activation, perhaps reducing the tensile strength of the podocyte actin cytoskeleton.

  2. Data, including data from studies in knockout mice, suggest that VDR (vitamin D receptor) regulates expression of ezrin in enterocytes; VDR (show CYP27B1 Proteins) appears not to be involved in morphology of tight junctions and absorption of large molecules in enterocytes.

  3. Lack of ezrin not only causes achlorhydria and hypergastrinemia but also changes the structure of gastric glands, with severe perturbation of the secretory membranes of parietal cells.

  4. our study demonstrates that ezrin is a novel regulator of IL-10 (show IL10 Proteins) production by B cells

  5. Merlin (show NF2 Proteins) and Ezrin are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor (show EGFR Proteins).

  6. Dysfunction of ezrin mimics important aspects of the pathological mechanisms responsible for cholangiopathies

  7. We hypothesize that polyvalent electrostatic interactions are responsible for the assembly of CD44 (show CD44 Proteins) clusters and the multimeric PIP2-CD44 (show CD44 Proteins)-Ezrin complexes.

  8. These results indicate that ezrin is required for uptake of hypotaurine from maternal serum by placental trophoblasts, and plays an important role in fetal growth.

  9. These data altogether suggest a novel role of ezrin in the neuritogenesis of the cultured cortical neurons through down-regulation of RhoA (show RHOA Proteins) activity.

  10. Beta-dystroglycan can respond to ezrin driven cytoskeletal and cell morphology changes,by translocating from the cytoplasm to the nucleus.

Pig (Porcine) Ezrin (EZR) interaction partners

  1. The cytoskeletal linker protein (show LAT Proteins) ezrin plays a significant role in hypothermic preservation injury in renal epithelia.

  2. Coexpression of ezrin with Eps8 promotes the formation of membrane ruffles and tufts of microvilli, whereas expression of ezrin and Eps8L1a induces the clustering of actin-containing structures at the cell surface.

  3. These findings reveal that direct ezrin interactions promote PTH1R apical localization and signaling in LLC-PK1 cells.

Rabbit Ezrin (EZR) interaction partners

  1. Spatial control of proton pump H,K-ATPase (show ATP1A1 Proteins) docking at the apical membrane by phosphorylation-coupled ezrin-syntaxin 3 (show STX3 Proteins) interaction.

  2. 1) NHE3 (show SLC9A3 Proteins) basal activity is regulated by a signaling complex that is controlled by sequential effects of two kinases, Akt (show AKT1 Proteins) and GSK-3, which act on a Ser (show SIGLEC1 Proteins) cluster in the same NHE3 (show SLC9A3 Proteins) C-terminal domain that binds ezrin

  3. Ezrin-mediated F-actin interaction with the epithelial cell may direct membrane recruitment and cytoskeletal surface extension.

  4. relatively high turnover of ezrin T567 phosphorylation was observed in all three epithelia (gastric, kidney and intestine).

Arabidopsis thaliana Ezrin (EZR) interaction partners

  1. VLN2 and VLN3 act redundantly in sclerenchyma development via bundling of actin filaments.

  2. Data indicate that the construction of actin collars was affected in vln2 vln5 double mutantpollen tubes.

  3. VLN2 and VLN3 play a role in actin filament organization in Arabidopsis.

Ezrin (EZR) Protein Profile

Protein Summary

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

Gene names and symbols associated with Ezrin Proteins (EZR)

  • ezrin (EZR)
  • ezrin b (ezrb)
  • ezrin (ezr)
  • moesin (msn)
  • ezrin (Ezr)
  • villin 2 (VLN2)
  • ATVLN2 protein
  • AW146364 protein
  • CVIL protein
  • CVL protein
  • ezr protein
  • p81 protein
  • R75297 protein
  • T11A7.16 protein
  • T11A7_16 protein
  • Vil2 protein
  • villin 2 protein
  • wu:fc05c03 protein
  • wu:fj31d06 protein

Protein level used designations for Ezrin Proteins (EZR)

villin 2 , cb567 , ezrin2 , villin 2 (ezrin) , cytovillin 2 , p81 , villin-2 , cytovillin

GENE ID SPECIES
100059467 Equus caballus
561589 Danio rerio
595017 Xenopus (Silurana) tropicalis
100145669 Xenopus (Silurana) tropicalis
7430 Homo sapiens
281574 Bos taurus
22350 Mus musculus
54319 Rattus norvegicus
484056 Canis lupus familiaris
100152815 Sus scrofa
100718943 Cavia porcellus
395701 Gallus gallus
100008846 Oryctolagus cuniculus
101837567 Mesocricetus auratus
818773 Arabidopsis thaliana
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